公开(公告)号：US08093349B2

公开(公告)日：2012-01-10

申请号：US12375211

申请日：2007-07-25

申请人： Kikuo Ataka ,  Tetsurou Tsuji

发明人： Kikuo Ataka ,  Tetsurou Tsuji

IPC分类号： C08G73/10 ,  C23C18/16

CPC分类号： C08G73/101 ,  C08G73/1007 ,  C08G73/1014 ,  C08G73/1017 ,  C08G73/1039 ,  C08G73/1046 ,  C08G73/105 ,  C08G73/1067 ,  C08G73/1071 ,  C08L79/08 ,  C23C18/30 ,  C23C18/31 ,  H05K1/0346 ,  H05K3/181 ,  H05K2201/0154 ,  Y10T428/31681

摘要： A terminally-modified polybranched polyimide which can be efficiently complexed with an inorganic material is obtained by reacting a component (a): tetracarboxylic dianhydride; a component (b): as an amine component, a mixture of a triamine and a diamine (which may be composed of a triamine only); and a component (c): as a terminal component, a compound selected from general formulae (1-1) to (1-4). H2N—X—R1  (1-1) (In the formula, X represents a single bond or an alkylene group having 1 to 3 carbon atoms, and R1 represents a nitrogen-containing heterocyclic group). H2N—X—R1  (1-2) (In the formula, X is as defined above, and R1 represents a sulfur-containing heterocyclic group or an aryl group having a thiol or thioether group in the molecule.) (In the formula, R represents a nitrogen-containing heterocyclic group.) (In the formula, R represents a monovalent residue.)

摘要翻译： 通过使成分（a）：四羧酸二酐反应，得到与无机材料有效配合的末端改性的聚支链聚酰亚胺。 组分（b）：作为胺组分，三胺和二胺的混合物（其可以仅由三胺组成）; 和组分（c）：作为终端组分，选自通式（1-1）至（1-4）的化合物。 H2N-X-R1（1-1）（式中，X表示单键或碳原子数1〜3的亚烷基，R1表示含氮杂环基）。 H 2 N-X-R 1（1-2）（式中X如上所述，R 1表示含硫杂环基或分子中具有硫醇或硫醚基的芳基）（式中， R表示含氮杂环基。）（式中，R表示1价残基。）

公开(公告)号：US06914154B2

公开(公告)日：2005-07-05

申请号：US10639324

申请日：2003-08-12

申请人： Yasushi Yamamoto ,  Tetsuro Tsuji ,  Jun Haruta ,  Kikuo Ataka ,  Noboru Kakeya

发明人： Yasushi Yamamoto ,  Tetsuro Tsuji ,  Jun Haruta ,  Kikuo Ataka ,  Noboru Kakeya

IPC分类号： C07C67/343 ,  C07C6/12 ,  C07C69/00 ,  C07C69/76 ,  C07F9/94

CPC分类号： C07C67/343 ,  C07C69/76

摘要： A production process, especially a continuous production process, for a biphenyltetracarboxylic acid tetraester characterized by carrying out, in parallel, a step of preliminarily mixing a phthalic acid diester and a palladium compound-containing catalyst to prepare a starting mixture, a step of continuously or intermittently supplying the starting mixture to a reactor, a step of conducting oxidative dimerization reaction of the phthalic acid diester in a temperature range of from 140° C. and lower than 250° C. while supplying molecular oxygen to the reactor to form a reaction mixture in the reactor, and a step of continuously or intermittently removing a portion of the reaction mixture from the reactor. Preferably, the palladium compound-containing catalyst in the starting mixture is dissolved in the phthalic acid diester, the palladium compound-containing catalyst comprises a palladium compound, a bidentate ligand and a copper compound, the reactor consists of a plurality of serially connected reactors and a carboxylic acid is also continuously or intermittently supplied to the reactor.

摘要翻译： 一种联苯四甲酸四酯的生产方法，特别是连续制备方法，其特征在于并行地进行预先混合邻苯二甲酸二酯和含钯化合物的催化剂以制备起始混合物的步骤，连续或 将起始混合物间歇地供应到反应器中，在140℃和低于250℃的温度范围内进行邻苯二甲酸二酯的氧化二聚反应的步骤，同时向反应器中供应分子氧以形成反应混合物 在反应器中，以及从反应器连续或间歇地除去反应混合物的一部分的步骤。 优选地，起始混合物中含钯化合物的催化剂溶解在邻苯二甲酸二酯中，含钯化合物的催化剂包括钯化合物，二齿配位体和铜化合物，反应器由多个串联的反应器和 羧酸也连续地或间歇地供应到反应器中。

公开(公告)号：US6121475A

公开(公告)日：2000-09-19

申请号：US397812

申请日：1999-09-17

申请人： Osamu Fujimura ,  Kikuo Ataka

发明人： Osamu Fujimura ,  Kikuo Ataka

IPC分类号： C07F7/18 ,  C07F7/08

CPC分类号： C07F7/1892

摘要： In a process for preparing an optically active .beta.-hydroxyester derivative by enantioselective aldol addition reaction between an aldehyde and a ketene silylacetal, the enantioselective aldol addition reaction is performed in the presence of an organic base and a platinum-containing catalyst composed of an optically active bisphosphine-platinum complex having two P--Pt bondings which are equivalent to each other, showing in its .sup.31 P NMR spectrum a single peak assigned to P--Pt bonding.

摘要翻译： 在通过醛和乙烯酮甲硅烷基缩醛之间的对映选择性醛醇加成反应制备光学活性β-羟酯衍生物的方法中，对映选择性醛醇醛加成反应在有机碱和含有光催化剂的铂催化剂存在下进行 具有彼此相同的两个P-Pt键的双膦 - 铂络合物，在31P NMR谱中显示了分配给P-Pt键的单峰。

公开(公告)号：US5874581A

公开(公告)日：1999-02-23

申请号：US817001

申请日：1997-03-31

申请人： Kikuo Ataka ,  Hiroyuki Miyata ,  Masahiko Kohno ,  Naoyuki Yokota ,  Yasuhito Yamamoto

发明人： Kikuo Ataka ,  Hiroyuki Miyata ,  Masahiko Kohno ,  Naoyuki Yokota ,  Yasuhito Yamamoto

IPC分类号： C07F7/18 ,  C07D471/04

CPC分类号： C07F7/1856

摘要： A 2-silyloxy-4,5,6,7-tetrahydrothieno�3,2-c!pyridine represented by the formula (I): ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 each independently represent an alkyl group having 1 to 10 carbon atoms or an aryl group,and a salt thereof and a process for preparing the same, and a 5-alkyl-2-silyloxy-4,5,6,7-tetrahydrothieno�3,2-c!-pyridine represented by the formula (IV): ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 represent the same meanings as described above; R.sup.4 represents a hydrogen atom, an alkoxycarbonyl group having 2 to 10 carbon atoms, an acyl group having 2 to 10 carbon atoms or a cyclo-alkylcarbonyl group having 4 to 10 carbon atoms; andR.sup.5 represents a halogen atom, an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms,which is useful as a synthetic intermediate of an antiplatelet medicine and an elastase inhibitor, etc., and a process for preparing the same.

摘要翻译： PCT No.PCT / JP95 / 02023 Sec。 371日期1997年3月31日 102（e）1997年3月31日PCT PCT 1995年10月4日PCT公布。 公开号WO96 / 11203 日期：1996年4月18日由式（I）表示的2-甲硅烷氧基-4,5,6,7-四氢噻吩并[3,2-c]吡啶：其中R 1，R 2和R 3各自独立地表示 具有1-10个碳原子的烷基或芳基，及其盐及其制备方法，和5-烷基-2-甲硅烷氧基-4,5,6,7-四氢噻吩并[3,2- （IV）表示的c]吡啶：其中R 1，R 2和R 3表示与上述相同的含义; R 4表示氢原子，碳原子数2〜10的烷氧基羰基，碳原子数2〜10的酰基或碳原子数4〜10的环烷基羰基。 R5表示卤素原子，碳原子数1〜4的烷基或碳原子数1〜4的烷氧基，可用作抗血小板药和弹性蛋白酶抑制剂的合成中间体等， 准备一样

公开(公告)号：US4831190A

公开(公告)日：1989-05-16

申请号：US126173

申请日：1987-11-27

申请人： Kikuo Ataka ,  Masayoshi Oku

发明人： Kikuo Ataka ,  Masayoshi Oku

IPC分类号： C07C51/38 ,  C07C65/03 ,  C07C65/21

CPC分类号： C07C65/21 ,  C07C51/38 ,  C07C65/03

摘要： There are disclosed 2,4,5-Trifluoro-3-hydroxybenzoic acid represented by the following formula (I): ##STR1## and a salt thereof and a process for preparing the same. Further, there is disclosed a process for preparing 3,5,6-trifluoro-4-hydroxyphthalic acid, which is employed for preparing the above compound.

公开(公告)号：US20070149823A1

公开(公告)日：2007-06-28

申请号：US10587369

申请日：2004-11-22

申请人： Kikuo Ataka ,  Hiroyuki Miyata ,  Tatsuya Kawaguchi ,  Junichi Yoshida ,  Kazuhiro Mae

发明人： Kikuo Ataka ,  Hiroyuki Miyata ,  Tatsuya Kawaguchi ,  Junichi Yoshida ,  Kazuhiro Mae

IPC分类号： C07C45/28

CPC分类号： C07C45/29 ,  C07C45/513 ,  C07C49/04 ,  C07C49/403 ,  C07C47/54 ,  C07C47/02

摘要： The method for producing an aldehyde or ketone compound from a corresponding primary or secondary alcohol at relatively high temperature within a short time with a high yield including a step (1) of reacting a sulfoxide compound with an activating agent to produce an activation reaction product; a step (2) of reacting the activation reaction product with a primary or secondary alcohol to produce an alkoxysulfonium salt; and a step (3) of reacting the reaction product with a base to produce an aldehyde or ketone; wherein at least one of the steps, preferably the step (1) and step (2), are carried out by using a microreactor.

摘要翻译： 在相当高的温度下在相当高的温度下以高收率生产醛或酮化合物的方法，包括使亚砜化合物与活化剂反应产生活化反应产物的步骤（1）; 使活化反应产物与伯醇或仲醇反应生成烷氧基锍盐的步骤（2）; 和使反应产物与碱反应产生醛或酮的步骤（3）; 其中至少一个步骤，优选步骤（1）和步骤（2））通过使用微反应器进行。

公开(公告)号：US06906039B2

公开(公告)日：2005-06-14

申请号：US10480275

申请日：2002-06-12

申请人： Hiroyuki Miyata ,  Akira Takama ,  Yasuhito Yamamoto ,  Kikuo Ataka

发明人： Hiroyuki Miyata ,  Akira Takama ,  Yasuhito Yamamoto ,  Kikuo Ataka

IPC分类号： C07H17/08 ,  A61K31/7048 ,  A61K31/70

CPC分类号： C07H17/08

摘要： The present invention is to provide a process for producing a 2′-O-acetyl-4″-O-formyl-8,9-anhydroerythromycin A 6,9-hemiketal compound 4, and it provide a process for producing an erythromycin compound which comprises reacting a formylating agent with a 2′-O-acetylerythromycin A compound 2 to obtain 2′-O-acetyl-4″-O-formylerythromycin A compound 3, then, acting an acid on Compound 3 to subject to hemiketalation, and then adding an aqueous basic solution in an aqueous solution to precipitate Compound 4 as free crystals.

摘要翻译： 本发明提供一种制备2'-O-乙酰基-4'-O-甲酰基-8,9-脱水红霉素A 6,9-半缩酮化合物 4的方法， 提供一种生产红霉素化合物的方法，其包括使甲酰化试剂与2'-O-乙酰红霉素A化合物 2反应，得到2'-O-乙酰基-4'-O-甲酰基红霉素A 化合物 3，然后在化合物 3上加入酸，进行半辛化，然后在水溶液中加入碱性水溶液沉淀化合物 4作为自由晶体。