公开(公告)号：US4898654A

公开(公告)日：1990-02-06

申请号：US357840

申请日：1989-05-26

申请人： Fumio Toda ,  Kouichi Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka

发明人： Fumio Toda ,  Kouichi Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka

IPC分类号： C07D205/12 ,  C07D487/04

CPC分类号： C07D487/04 ,  C07D205/12

摘要： Disclosed is a method of producing an optically active .beta.-lactam derivative of the formula ##STR1## comprising irradiating with light, in solid phase, an inclusion complex of a compound of the formula ##STR2## with an optically active host compound.

摘要翻译： 公开了一种制备式（II）的光学活性β-内酰胺衍生物的方法，包括用固相照射下式的化合物（I）的包合络合物与光学活性物质 主体化合物。

公开(公告)号：US5288860A

公开(公告)日：1994-02-22

申请号：US3024

申请日：1993-01-11

申请人： Sigeru Torii ,  Hideo Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Takashi Shiroi ,  Yutaka Kameyama

发明人： Sigeru Torii ,  Hideo Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Takashi Shiroi ,  Yutaka Kameyama

IPC分类号： C07D499/00 ,  C07D499/04 ,  C07D499/12 ,  C07D499/87 ,  C07D513/04

CPC分类号： C07D513/04 ,  C07D499/00 ,  Y02P20/55

摘要： The present invention provides a thiazolinoazetidinone derivative represented by the formula ##STR1## wherein R.sup.1 is phenyl having or not having substituent(s), methyl having or not having substituent(s) or ##STR2## group, R.sup.3 being phenyl having or not having substituent(s), and R.sup.2 is a hydrogen atom or carboxylic acid protective group, and a process for preparing the same.The present invention further provides a process for preparing a 2-exo-methylenepenam derivative characterized by hydrolyzing the thiazoline ring of a thiazolinoazetidinone derivative of the above formula (1) to effect recyclization and obtain a 2-exo-methylenepenam derivative represented by the formula ##STR3## wherein R.sup.1 and R.sup.2 are as defined above.

摘要翻译： 本发明提供由式（1）表示的噻唑并氮杂环丁酮衍生物，其中R 1是具有或不具有取代基的苯基，具有或不具有取代基的甲基或基团，R3是具有或不具有取代基的苯基， 不具有取代基，R2为氢原子或羧酸保护基，及其制备方法。 本发明进一步提供了制备2-异亚甲基台内叶酸衍生物的方法，其特征在于水解上述式（1）的噻唑并氮杂环丁酮衍生物的噻唑啉环以进行再循环，得到式（1）所示的2-外 - 亚甲基山梨醇衍生物， 图像（3）其中R1和R2如上所定义。

公开(公告)号：US4958018A

公开(公告)日：1990-09-18

申请号：US347319

申请日：1989-05-04

申请人： Sigeru Torii ,  Hideo Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Norio Saito ,  Takashi Shiroi ,  Shigemitsu Nagao ,  Ryo Kikuchi ,  Yutaka Kameyama

发明人： Sigeru Torii ,  Hideo Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Norio Saito ,  Takashi Shiroi ,  Shigemitsu Nagao ,  Ryo Kikuchi ,  Yutaka Kameyama

IPC分类号： B01J23/14 ,  C07B61/00 ,  C07D501/04 ,  C07D501/22

CPC分类号： C07D501/04 ,  Y02P20/55

摘要： Disclosed is a method of producing a 3-exomethylenecepham of the formula ##STR1## wherein R.sup.1 is amino or substituted amino and R.sup.2 is a carboxy-protecting group comprising reacting a cephem of the formula ##STR2## wherein R.sup.1 and R.sup.2 are as defined above and X is halogen with lead metal while maintaining the pH of the reaction system at about 0.1 to 8. The cephem (I) may be reacted with a catalytic amount of lead metal or a lead compound in the presence of a metal having a greater ionization tendency than lead.

公开(公告)号：US4886891A

公开(公告)日：1989-12-12

申请号：US134852

申请日：1987-12-18

申请人： Shigeru Torii ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Yoshihisa Tomotaki ,  Mitsuo Akada ,  Hideo Tanaka ,  Akira Suzuki ,  Shiro Yamashita

发明人： Shigeru Torii ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Yoshihisa Tomotaki ,  Mitsuo Akada ,  Hideo Tanaka ,  Akira Suzuki ,  Shiro Yamashita

IPC分类号： C07C43/225 ,  C07B31/00 ,  C07B35/02 ,  C07B37/06 ,  C07C17/00 ,  C07C17/35 ,  C07C17/363 ,  C07C21/04 ,  C07C21/19 ,  C07C22/02 ,  C07C22/04 ,  C07C27/00 ,  C07C29/00 ,  C07C33/40 ,  C07C33/42 ,  C07C37/00 ,  C07C37/50 ,  C07C39/373 ,  C07C41/00 ,  C07C41/24 ,  C07C45/00 ,  C07C45/65 ,  C07C49/463 ,  C07C49/687 ,  C07C49/80 ,  C07C51/00 ,  C07C51/09 ,  C07C57/52 ,  C07C67/00 ,  C07C67/317 ,  C07C69/618 ,  C07C69/743 ,  C07C231/00 ,  C07C231/12 ,  C07C233/03 ,  C07C233/11 ,  C07C253/00 ,  C07C253/30 ,  C07C255/10 ,  C07C255/31 ,  C07C255/35 ,  C07C255/54 ,  C07D317/52

CPC分类号： C07C255/00 ,  C07C17/00 ,  C07C17/363 ,  C07C29/58 ,  C07C37/001 ,  C07C37/002 ,  C07C41/24 ,  C07C45/65 ,  C07C49/687 ,  C07C49/80 ,  C07C51/09 ,  C07C67/327 ,  C07D317/52 ,  C07C2101/16 ,  C07C2101/18

摘要： The present invention provides a process for preparing a 1,1-disubstituted ethylene derivative of the formula ##STR1## which comprises reacting lead with a carbinol derivative of the formula ##STR2## wherein R.sup.1, R.sup.2, R.sup.3, X, Y, m and n are defined in the specification. The reaction is conducted more advantageously in the presence of a metal having higher ionization tendency than lead.

公开(公告)号：US5126447A

公开(公告)日：1992-06-30

申请号：US662605

申请日：1991-03-01

申请人： Sigeru Torii ,  Hideo Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Takashi Shiroi ,  Ryo Kikuchi ,  Yutaka Kameyama

发明人： Sigeru Torii ,  Hideo Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Takashi Shiroi ,  Ryo Kikuchi ,  Yutaka Kameyama

IPC分类号： B01J23/36 ,  B01J23/46 ,  C01B11/22 ,  C07B61/00 ,  C07D205/085 ,  C07D205/095 ,  C07D403/04 ,  C07D405/14 ,  C07F7/18

CPC分类号： C07D403/04 ,  C07D205/085 ,  C07D205/095 ,  C07D405/14 ,  C07F7/186 ,  Y02P20/55

摘要： A process for preparing a .beta.-lactam derivative of formula (2) and/or the corresponding enol tautomer, which includes oxidizing an alkenyl-substituted .beta.-lactam derivative of formula (1) in the presence of a ruthenium catalyst or a rhenium catalyst using a periodic acid: ##STR1## wherein R.sup.1 is a hydrogen atom, a C.sub.1-4 alkyl group or a C.sub.1-4 haloalkyl group, R.sup.2 is a hydrogen atom, a C.sub.1-4 alkyl group or a phenyl group which may have a substituent, A is a group selected from ##STR2## wherein R.sup.3 is an amino group or a protected amino group, and R.sup.4 -R.sup.8 are as defined in the application.

公开(公告)号：US5206361A

公开(公告)日：1993-04-27

申请号：US665863

申请日：1991-03-07

申请人： Sigeru Torii ,  Hideo Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Takashi Shiroi ,  Yutaka Kameyama

发明人： Sigeru Torii ,  Hideo Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Takashi Shiroi ,  Yutaka Kameyama

IPC分类号： C07D499/00 ,  C07D499/04 ,  C07D499/12 ,  C07D499/87 ,  C07D513/04

CPC分类号： C07D513/04 ,  C07D499/00 ,  Y02P20/55

摘要： The present invention provides a thiazolinoazetidinone derivative represented by the formula ##STR1## wherein R.sup.1 is phenyl having or not having substituent(s), methyl having or not having substituent(s) or ##STR2## group, R.sup.3 being phenyl having or not having substituent(s), and R.sup.2 is a hydrogen atom or carboxylic acid protective group, and a process for preparing the same.The present invention further provides a process for preparing a 2-exo-methylenepenam derivative characterized by hydrolyzing the thiazoline ring of a thiazolinoazetidinone derivative of the above formula (1) to effect recyclization and obtain a 2-exo-methylenepenam derivative represented by the formula ##STR3## wherein R.sup.1 and R.sup.2 are as defined above.

公开(公告)号：US5142040A

公开(公告)日：1992-08-25

申请号：US665838

申请日：1991-03-07

申请人： Sigeru Torii ,  Hideo Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Takashi Shiroi ,  Ryo Kikuchi ,  Yutaka Kameyama

发明人： Sigeru Torii ,  Hideo Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Takashi Shiroi ,  Ryo Kikuchi ,  Yutaka Kameyama

IPC分类号： C07D501/00 ,  C07D501/04 ,  C07D501/24 ,  C07D501/26

CPC分类号： C07D501/00 ,  Y02P20/55

摘要： The present invention provides a process for preparing a 3-formylcephem derivative represented by the formula (2) ##STR1## which comprises oxidizing in the presence of oxygen a 3-halomethylcephem derivative represented by the formula (1) ##STR2## wherein R.sup.1 is amino group or protected amino group, R.sup.2 is hydrogen atom or a carboxylic acid protective group, X is halogen atom.

公开(公告)号：US4925934A

公开(公告)日：1990-05-15

申请号：US317322

申请日：1989-03-01

申请人： Masatoshi Taniguchi ,  Michio Sasaoka ,  Kiyotoshi Matsumura ,  Ichiro Kawahara ,  Kenji Kaze ,  Daisuke Suzuki ,  Akihiro Shimabayashi

发明人： Masatoshi Taniguchi ,  Michio Sasaoka ,  Kiyotoshi Matsumura ,  Ichiro Kawahara ,  Kenji Kaze ,  Daisuke Suzuki ,  Akihiro Shimabayashi

IPC分类号： C07D499/87 ,  C07D499/00 ,  C07D499/08 ,  C07D499/86 ,  C07D499/897

CPC分类号： C07D499/00 ,  Y02P20/55

摘要： The invention provides a process for preparing a .beta.-lactam derivative represented by the formula ##STR1## the process comprising reacting a .beta.-lactam derivative represented by the following formula (II) and having a protected carboxyl group with a cresol; ##STR2## wherein R represents a benzyl group having an electron-donating group as a substituent on the phenyl ring, a diphenylmethyl group which may have an electron-donating group as a substituent on the phenyl ring or a tert-butyl group.

公开(公告)号：US4912213A

公开(公告)日：1990-03-27

申请号：US241186

申请日：1988-09-07

申请人： Masatoshi Taniguchi ,  Michio Sasaoka ,  Kiyotoshi Matsumura ,  Ichiro Kawahara ,  Kenji Kase ,  Daisuke Suzuki ,  Shigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Akira Nakai

发明人： Masatoshi Taniguchi ,  Michio Sasaoka ,  Kiyotoshi Matsumura ,  Ichiro Kawahara ,  Kenji Kase ,  Daisuke Suzuki ,  Shigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Akira Nakai

IPC分类号： C07D499/87 ,  B01J23/14 ,  B01J27/135 ,  C07B61/00 ,  C07D499/00 ,  C07D499/86 ,  C07D499/897

CPC分类号： C07D499/00 ,  Y02P20/55

摘要： The present invention provides a process for preparing a penicillanic acid derivative of the formula ##STR1## which comprises reacting lead with a halogenated penicillanic acid derivative of the formula ##STR2## wherein X, Y, Z and R.sup.1 are as defined in the specification. The reaction is advantageously conducted in the presence of a metal having higher ionization tendency than lead such as aluminum, iron, magnesium or a mixture thereof.

公开(公告)号：US5204458A

公开(公告)日：1993-04-20

申请号：US849160

申请日：1992-03-10

申请人： Sigeru Torii ,  Hideo Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Takashi Shiroi ,  Yutaka Kameyama

发明人： Sigeru Torii ,  Hideo Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Takashi Shiroi ,  Yutaka Kameyama

IPC分类号： C07D501/00 ,  C07D501/08 ,  C07D501/59

CPC分类号： C07D501/00 ,  Y02P20/55

摘要： The present invention provides a process for preparing a cephem derivative characterized in that an allenyl .beta.-lactam compound represented by the formula (1) ##STR1## wherein R.sup.1 is amino or protected amino, R.sup.2 is a hydrogen atom or lower alkoxyl, R.sup.3 is a hydrogen atom or carboxylic acid protecting group and X is the group --SO.sub.2 R.sup.4 or --SR.sup.4, R.sup.4 being substituted or unsubstituted aryl or substituted or unsubstituted nitrogen-containing aromatic heterocyclic group is reacted with a nucleophilic agent to obtain the derivative, the cephem derivative being represented by the formula (2) ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined above, and Y is the residue of the nucleophilic agent.