公开(公告)号：US20140309315A1

公开(公告)日：2014-10-16

申请号：US14313151

申请日：2014-06-24

Applicant: FzioMed, Inc.

Inventor： Samuel J. Falcone ,  Richard A. Berg

IPC: A61K47/48 ,  A61L31/04

CPC classification number: A61L27/20 ,  A61F2/441 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30242 ,  A61F2002/30581 ,  A61F2002/30677 ,  A61F2002/3068 ,  A61F2002/4435 ,  A61F2002/444 ,  A61F2002/448 ,  A61F2210/0004 ,  A61F2230/0071 ,  A61F2250/0068 ,  A61K47/60 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/042 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2400/06 ,  A61L2400/10 ,  A61L2430/02 ,  A61L2430/38 ,  C08B11/20 ,  C08J3/246 ,  C08J2301/08 ,  C08J2471/00 ,  C08L1/286 ,  Y10T428/2982 ,  C08L1/28

Abstract: Compositions comprising carboxypolysaccharides (CPS) including carboxymethyl cellulose (CMC) and polyethylene glycols (PEGs) are provided where the PEG is a PEG-epoxide covalently linked to the CPS. In certain embodiments, the PEG attaches to only one CPS, forming a decorated CPS. In other embodiments, bi-functional PEG molecules are attached to adjacent CPSs, thereby forming a covalently cross-linked composition. Additional embodiments include PEG/CMC compositions where the PEG is a multi-branch PEG and/or a multi-arm PEG. PEG/CMC compositions can be made with desired viscoelastic properties, and such compositions can be used as space-filling materials, load-bearing materials, anti-adhesion compositions, drug delivery vehicles or lubrication of tissues and medical instruments.

Abstract translation: 提供包含羧甲纤维素（CMC）和聚乙二醇（PEG）的羧基多糖（CPS）的组合物，其中PEG是与CPS共价连接的PEG-环氧化物。 在某些实施方案中，PEG仅附着于一个CPS，形成装饰的CPS。 在其它实施方案中，双功能PEG分子连接到相邻的CPS，由此形成共价交联的组合物。 另外的实施方案包括其中PEG是多支PEG和/或多臂PEG的PEG / CMC组合物。 PEG / CMC组合物可以制备具有所需的粘弹性质，并且这些组合物可用作空间填充材料，承载材料，抗粘附组合物，药物递送载体或组织和医疗仪器的润滑。

公开(公告)号：US09381271B2

公开(公告)日：2016-07-05

申请号：US14887717

申请日：2015-10-20

Applicant: FzioMed, Inc.

Inventor： Samuel J. Falcone ,  Richard A. Berg

IPC: C08L1/00 ,  A61L27/20 ,  A61F2/44 ,  A61L27/50 ,  A61L27/54 ,  A61L31/04 ,  A61L31/14 ,  A61L31/16 ,  C08B11/20 ,  C08L1/28 ,  A61K47/48 ,  A61L27/58 ,  A61L31/06 ,  A61F2/30

CPC classification number: A61L27/20 ,  A61F2/441 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30242 ,  A61F2002/30581 ,  A61F2002/30677 ,  A61F2002/3068 ,  A61F2002/4435 ,  A61F2002/444 ,  A61F2002/448 ,  A61F2210/0004 ,  A61F2230/0071 ,  A61F2250/0068 ,  A61K47/60 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/042 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2400/06 ,  A61L2400/10 ,  A61L2430/02 ,  A61L2430/38 ,  C08B11/20 ,  C08J3/246 ,  C08J2301/08 ,  C08J2471/00 ,  C08L1/286 ,  Y10T428/2982 ,  C08L1/28

Abstract: Uses of compositions comprising carboxypolysaccharides (CPS) including carboxymethyl cellulose (CMC) and polyethylene glycols (PEGs) are provided where the PEG is a PEG-epoxide covalently linked to the CPS in the presence of NH4OH. In certain embodiments, the PEG attaches to only one CPS, forming a decorated CPS. In other embodiments, bi-functional PEG molecules are attached to adjacent CPSs, thereby forming a covalently cross-linked composition. Such compositions can be used as space-filling materials, load-bearing materials, anti-adhesion compositions, drug delivery vehicles, and lubricants of tissues and medical instruments.

Abstract translation: 提供包含羧甲纤维素（CMC）和聚乙二醇（PEG）的羧基多糖（CPS）的组合物的用途，其中PEG是在NH 4 OH存在下与CPS共价连接的PEG-环氧化物。 在某些实施方案中，PEG仅附着于一个CPS，形成装饰的CPS。 在其它实施方案中，双功能PEG分子连接到相邻的CPS，由此形成共价交联的组合物。 这种组合物可用作空间填充材料，承载材料，抗粘连组合物，药物递送载体和组织和医疗仪器的润滑剂。

公开(公告)号：US09682167B2

公开(公告)日：2017-06-20

申请号：US15189496

申请日：2016-06-22

Applicant: Fziomed, Inc.

Inventor： Samuel J. Falcone ,  Richard A. Berg

IPC: A61L27/20 ,  A61L27/54 ,  A61L31/06 ,  A61F2/44 ,  C08J5/24 ,  A61L27/50 ,  A61L31/04 ,  A61L31/14 ,  A61L31/16 ,  C08B11/20 ,  C08L1/28 ,  A61K47/48 ,  A61L27/58 ,  A61L27/56 ,  C08J3/24 ,  A61F2/30

CPC classification number: A61L27/20 ,  A61F2/441 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30242 ,  A61F2002/30581 ,  A61F2002/30677 ,  A61F2002/3068 ,  A61F2002/4435 ,  A61F2002/444 ,  A61F2002/448 ,  A61F2210/0004 ,  A61F2230/0071 ,  A61F2250/0068 ,  A61K47/60 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/042 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2400/06 ,  A61L2400/10 ,  A61L2430/02 ,  A61L2430/38 ,  C08B11/20 ,  C08J3/246 ,  C08J2301/08 ,  C08J2471/00 ,  C08L1/286 ,  Y10T428/2982 ,  C08L1/28

Abstract: Compositions and method of manufacturing carboxypolysaccharides (CPS) including carboxymethyl cellulose (CMC) and polyethylene glycols (PEGs) are provided where the PEG is a PEG-epoxide covalently linked to the CPS. In certain embodiments, the PEG attaches to only one CPS, forming a decorated CPS. In other embodiments, the functional groups of a bi-functional PEG molecule (PEG diglycidyl ether) are attached to different CPSs, thereby forming a covalently cross-linked composition. Such compositions can be used as space-filling materials, load-bearing materials, anti-adhesion compositions, drug delivery vehicles, and lubricants of tissues and medical instruments.

公开(公告)号：US09161987B2

公开(公告)日：2015-10-20

申请号：US14313151

申请日：2014-06-24

Applicant: FzioMed, Inc.

Inventor： Samuel J. Falcone ,  Richard A. Berg

IPC: A61K47/48 ,  A61F2/44 ,  A61L27/20 ,  A61L27/50 ,  A61L27/54 ,  A61L31/04 ,  A61L31/14 ,  A61L31/16 ,  C08B11/20 ,  C08L1/28 ,  A61F2/30

CPC classification number: A61L27/20 ,  A61F2/441 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30242 ,  A61F2002/30581 ,  A61F2002/30677 ,  A61F2002/3068 ,  A61F2002/4435 ,  A61F2002/444 ,  A61F2002/448 ,  A61F2210/0004 ,  A61F2230/0071 ,  A61F2250/0068 ,  A61K47/60 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/042 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2400/06 ,  A61L2400/10 ,  A61L2430/02 ,  A61L2430/38 ,  C08B11/20 ,  C08J3/246 ,  C08J2301/08 ,  C08J2471/00 ,  C08L1/286 ,  Y10T428/2982 ,  C08L1/28

Abstract: Compositions comprising carboxypolysaccharides (CPS) including carboxymethyl cellulose (CMC) and polyethylene glycols (PEGs) are provided where the PEG is a PEG-epoxide covalently linked to the CPS. In certain embodiments, the PEG attaches to only one CPS, forming a decorated CPS. In other embodiments, bi-functional PEG molecules are attached to adjacent CPSs, thereby forming a covalently cross-linked composition. Additional embodiments include PEG/CMC compositions where the PEG is a multi-branch PEG and/or a multi-arm PEG. PEG/CMC compositions can be made with desired viscoelastic properties, and such compositions can be used as space-filling materials, load-bearing materials, anti-adhesion compositions, drug delivery vehicles or lubrication of tissues and medical instruments.

Abstract translation: 提供包含羧甲纤维素（CMC）和聚乙二醇（PEG）的羧基多糖（CPS）的组合物，其中PEG是与CPS共价连接的PEG-环氧化物。 在某些实施方案中，PEG仅附着于一个CPS，形成装饰的CPS。 在其它实施方案中，双功能PEG分子连接到相邻的CPS，由此形成共价交联的组合物。 另外的实施方案包括其中PEG是多支PEG和/或多臂PEG的PEG / CMC组合物。 PEG / CMC组合物可以制备具有所需的粘弹性质，并且这些组合物可用作空间填充材料，承载材料，抗粘附组合物，药物递送载体或组织和医疗仪器的润滑。

公开(公告)号：US20160303280A1

公开(公告)日：2016-10-20

申请号：US15189496

申请日：2016-06-22

Applicant: Fziomed, Inc.

Inventor： Samuel J. Falcone ,  Richard A. Berg

IPC: A61L27/20 ,  A61L27/56 ,  A61L31/04 ,  A61F2/44 ,  A61L31/14 ,  A61K47/48 ,  C08J3/24 ,  A61L27/54 ,  A61L31/16

CPC classification number: A61L27/20 ,  A61F2/441 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30242 ,  A61F2002/30581 ,  A61F2002/30677 ,  A61F2002/3068 ,  A61F2002/4435 ,  A61F2002/444 ,  A61F2002/448 ,  A61F2210/0004 ,  A61F2230/0071 ,  A61F2250/0068 ,  A61K47/60 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/042 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2400/06 ,  A61L2400/10 ,  A61L2430/02 ,  A61L2430/38 ,  C08B11/20 ,  C08J3/246 ,  C08J2301/08 ,  C08J2471/00 ,  C08L1/286 ,  Y10T428/2982 ,  C08L1/28

Abstract: Compositions and method of manufacturing carboxypolysaccharides (CPS) including carboxymethyl cellulose (CMC) and polyethylene glycols (PEGs) are provided where the PEG is a PEG-epoxide covalently linked to the CPS. In certain embodiments, the PEG attaches to only one CPS, forming a decorated CPS. In other embodiments, the functional groups of a bi-functional PEG molecule (PEG diglycidyl ether) are attached to different CPSs, thereby forming a covalently cross-linked composition. Such compositions can be used as space-filling materials, load-bearing materials, anti-adhesion compositions, drug delivery vehicles, and lubricants of tissues and medical instruments.

Abstract translation: 提供了包含羧甲基纤维素（CMC）和聚乙二醇（PEG）的羧基多糖（CPS）的组合物和方法，其中PEG是与CPS共价连接的PEG-环氧化物。 在某些实施方案中，PEG仅附着于一个CPS，形成装饰的CPS。 在其它实施方案中，双功能PEG分子（PEG二缩水甘油醚）的官能团连接到不同的CPS上，从而形成共价交联的组合物。 这种组合物可用作空间填充材料，承载材料，抗粘连组合物，药物递送载体和组织和医疗仪器的润滑剂。

公开(公告)号：US20160038634A1

公开(公告)日：2016-02-11

申请号：US14887717

申请日：2015-10-20

Applicant: FzioMed, Inc.

Inventor： Samuel J. Falcone ,  Richard A. Berg

IPC: A61L27/20 ,  A61L31/04 ,  A61L31/14 ,  A61L31/06 ,  A61L27/50 ,  A61L27/58

CPC classification number: A61L27/20 ,  A61F2/441 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30242 ,  A61F2002/30581 ,  A61F2002/30677 ,  A61F2002/3068 ,  A61F2002/4435 ,  A61F2002/444 ,  A61F2002/448 ,  A61F2210/0004 ,  A61F2230/0071 ,  A61F2250/0068 ,  A61K47/60 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/042 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2400/06 ,  A61L2400/10 ,  A61L2430/02 ,  A61L2430/38 ,  C08B11/20 ,  C08J3/246 ,  C08J2301/08 ,  C08J2471/00 ,  C08L1/286 ,  Y10T428/2982 ,  C08L1/28

Abstract: Uses of compositions comprising carboxypolysaccharides (CPS) including carboxymethyl cellulose (CMC) and polyethylene glycols (PEGs) are provided where the PEG is a PEG-epoxide covalently linked to the CPS in the presence of NH4OH. In certain embodiments, the PEG attaches to only one CPS, forming a decorated CPS. In other embodiments, bi-functional PEG molecules are attached to adjacent CPSs, thereby forming a covalently cross-linked composition. Such compositions can be used as space-filling materials, load-bearing materials, anti-adhesion compositions, drug delivery vehicles, and lubricants of tissues and medical instruments.

Abstract translation: 提供包含羧甲纤维素（CMC）和聚乙二醇（PEG）的羧基多糖（CPS）的组合物的用途，其中PEG是在NH 4 OH存在下与CPS共价连接的PEG-环氧化物。 在某些实施方案中，PEG仅附着于一个CPS，形成装饰的CPS。 在其它实施方案中，双功能PEG分子连接到相邻的CPS，由此形成共价交联的组合物。 这种组合物可用作空间填充材料，承载材料，抗粘连组合物，药物递送载体和组织和医疗仪器的润滑剂。