公开(公告)号：US07495209B2

公开(公告)日：2009-02-24

申请号：US11440803

申请日：2006-05-25

申请人： Gökhan Baykut ,  Christian Berg ,  Jochen Franzen

发明人： Gökhan Baykut ,  Christian Berg ,  Jochen Franzen

IPC分类号： B01D59/44

CPC分类号： H01J49/38

摘要： The invention relates to methods and devices for regulating the filling level in measuring cells of ion cyclotron resonance mass spectrometers so that it is optimal for mass resolution and mass accuracy. The invention consists in supplying a fraction of the samples to a second reference mass spectrometer operated in parallel, and employing the mass spectra obtained from this reference mass spectrometer to regulate the filling level in the ion cyclotron resonance mass spectrometer.

摘要翻译： 本发明涉及用于调节离子回旋共振质谱仪测量单元中的填充水平的方法和装置，使其对于质量分辨率和质量精度是最佳的。 本发明包括将一部分样品供应到并行操作的第二参考质谱仪，并使用从该参考质谱仪获得的质谱来调节离子回旋共振质谱仪中的填充水平。

公开(公告)号：US08410429B2

公开(公告)日：2013-04-02

申请号：US13017803

申请日：2011-01-31

申请人： Jochen Franzen ,  Gökhan Baykut ,  Oliver Räther ,  Carsten Stoermer ,  Evgenij Nikolaev

发明人： Jochen Franzen ,  Gökhan Baykut ,  Oliver Räther ,  Carsten Stoermer ,  Evgenij Nikolaev

IPC分类号： H01J49/06 ,  H01J49/36

CPC分类号： H01J49/4205 ,  H01J49/062

摘要： An ion cell having an axis includes a sheath of individual electrodes that extends along the axis and defines an internal volume. Adjacent individual electrodes are electrically insulated from each other. The individual electrodes each receive a DC potential and RF voltage. At least some of the individual electrodes have a width that varies in the axial direction such that an electrical effect on an axis potential varies along the axis of the ion cell.

摘要翻译： 具有轴的离子电池包括沿着轴线延伸并且限定内部体积的各个电极的护套。 相邻的单个电极彼此电绝缘。 各个电极各自接收DC电位和RF电压。 单个电极中的至少一些具有在轴向上变化的宽度，使得轴电位上的电效应沿离子电池的轴线变化。

公开(公告)号：US06555814B1

公开(公告)日：2003-04-29

申请号：US09607774

申请日：2000-06-30

申请人： Gökhan Baykut ,  Jochen Franzen

发明人： Gökhan Baykut ,  Jochen Franzen

IPC分类号： B01D5944

CPC分类号： H01J49/063 ,  H01J49/38 ,  H01J49/4265

摘要： The invention relates to a method and a device for controlling the number of ions in ion cyclotron resonance (ICR) mass spectrometers, whereby the ions enter a multipole ion guide after their formation and are stored there temporarily. By measuring the ion number in a predefined subset of these temporarily stored ions, the number of ions transferred into the ICR trap for mass spectrometric analysis is regulated. A mode of operation of the multipole ion guide can ensure that undesirable mass ranges are filtered out before the transfer of ions into the ICR mass spectrometer. The invention makes it possible to eliminate space charge effects, which are caused by overfilling the ICR traps.

摘要翻译： 本发明涉及一种用于控制离子回旋共振（ICR）质谱仪中的离子数的方法和装置，由此离子在其形成后进入多极离子导向器并暂时储存在其中。 通过测量这些临时存储的离子的预定子集中的离子数，调节转移到用于质谱分析的ICR阱中的离子数。 多极离子导向器的操作模式可以确保在将离子转移到ICR质谱仪之前过滤不需要的质量范围。 本发明使得可以消除由过度填充ICR陷阱引起的空间电荷效应。

公开(公告)号：US20100090102A1

公开(公告)日：2010-04-15

申请号：US12548945

申请日：2009-08-27

申请人： Oliver Räther ,  Gökhan Baykut ,  Jochen Franzen

发明人： Oliver Räther ,  Gökhan Baykut ,  Jochen Franzen

IPC分类号： B01D59/44 ,  H01J49/00

CPC分类号： H01J49/062 ,  G01N27/622

摘要： Ion mobilities are measured by entraining the ions in a gas and adiabatically expanding the ion-containing gas through a nozzle to form a gas jet. An electrical field barrier with variable height is located at the nozzle exit. The field barrier may be located adjacent to the nozzle exit or an ion guide may be located between the nozzle and the field barrier. If a continuous ion current is supplied, the height of the barrier is varied and the ion current of the ions passing over the barrier is measured, the ion current can be differentiated to generate a mobility spectrum. Alternatively, the ions can be temporarily stored in the ion guide so that measurement of the ion current of the ions passing over the barrier results in a direct measurement of the mobility spectrum.

摘要翻译： 通过夹带气体中的离子并通过喷嘴绝热地使含离子的气体膨胀以形成气体射流来测量离子迁移率。 具有可变高度的电场屏障位于喷嘴出口处。 场屏障可以位于喷嘴出口附近，或者离子引导件可以位于喷嘴和场屏障之间。 如果提供连续的离子电流，则屏障的高度变化，并且测量通过势垒的离子的离子电流，离子电流可以被微分以产生迁移谱。 或者，离子可以临时存储在离子导向器中，使得通过势垒的离子的离子电流的测量导致对迁移谱的直接测量。

公开(公告)号：US07893402B2

公开(公告)日：2011-02-22

申请号：US12052267

申请日：2008-03-20

申请人： Ian Sanders ,  Gökhan Baykut ,  Jochen Franzen

发明人： Ian Sanders ,  Gökhan Baykut ,  Jochen Franzen

IPC分类号： B01D59/44

CPC分类号： H01J49/004 ,  G01N27/622

摘要： The mobility of mass-selected ions in gases is measured at pressures of a few hectopascal by selecting the ions under investigation in a quadrupole filter according to their mass-to-charge ratio m/z, measuring their mobility in a drift region at a pressure of a few hundred Pascal under the influence of a DC electric field and then filtering the measured ions by means of a quadrupole field in order to eliminate, or detect changes in, the mass-to-charge ratio. Several embodiments for the drift region are disclosed, in which the ions are kept in the axis of the drift region by RF fields. As these drift regions can also be utilized for a collision-induced decomposition of the ions, the device can additionally be used as a so-called triple quadrupole mass spectrometer.

摘要翻译： 质量选择的离子在气体中的迁移率通过在四极滤波器中根据其质荷比m / z选择正在研究的离子来测量几何百帕斯卡的压力，测量它们在压力下的漂移区域中的迁移率 在直流电场的影响下，几百帕斯卡，然后通过四极场过滤测量的离子，以消除或检测质荷比的变化。 公开了漂移区的几个实施例，其中通过RF场将离子保持在漂移区的轴上。 由于这些漂移区域也可以用于离子的碰撞诱导分解，因此该装置可另外用作所谓的三重四极杆质谱仪。

公开(公告)号：US07718959B2

公开(公告)日：2010-05-18

申请号：US11843753

申请日：2007-08-23

申请人： Jochen Franzen ,  Gökhan Baykut

发明人： Jochen Franzen ,  Gökhan Baykut

IPC分类号： H01J49/42

CPC分类号： H01J49/4225 ,  H01J49/063 ,  H01J49/4295

摘要： The invention relates to instruments for storing ions in more than one ion storage device and to the use of the storage bank thus created. The ion storage bank includes several storage cells configured as RF multipole rod systems, where the cells contain damping gas and are arranged in parallel. Each pair of pole rods is used jointly by two immediately adjacent storage cells such that the ions collected can be transported from one storage cell to the next by briefly applying DC or AC voltages to individual pairs of pole rods. The ions can thus be transported to storage cells in which they are fragmented or reactively modified, or from which they can be fed to other spectrometers. In particular, a circular arrangement of the storage cells on a virtual cylindrical surface makes it possible to accumulatively fill the storage cells with ions of specific fractions from temporally sequenced separation runs.

摘要翻译： 本发明涉及用于将离子存储在多于一个离子存储装置中的仪器以及由此产生的储存库的使用。 离子存储库包括配置为RF多极杆系统的多个存储单元，其中单元包含阻尼气体并且并联布置。 每对极杆由两个紧邻的存储单元联合使用，使得通过向单个极杆对简单地施加DC或AC电压，所收集的离子可以从一个存储单元传送到下一个存储单元。 因此，离子可以被运送到它们被分段或反应性修饰的存储单元中，或者从这些离子将它们送入其它光谱仪。 特别地，在虚拟圆柱形表面上的存储单元的圆形布置使得可以从时间上排序的分离行程累积地填充具有特定级分的离子的存储单元。

公开(公告)号：US08080787B2

公开(公告)日：2011-12-20

申请号：US12548945

申请日：2009-08-27

申请人： Oliver Räther ,  Gökhan Baykut ,  Jochen Franzen

发明人： Oliver Räther ,  Gökhan Baykut ,  Jochen Franzen

IPC分类号： B01D59/44

CPC分类号： H01J49/062 ,  G01N27/622

摘要： Ion mobilities are measured by entraining the ions in a gas and adiabatically expanding the ion-containing gas through a nozzle to form a gas jet. An electrical field barrier with variable height is located at the nozzle exit. The field barrier may be located adjacent to the nozzle exit or an ion guide may be located between the nozzle and the field barrier. If a continuous ion current is supplied, the height of the barrier is varied and the ion current of the ions passing over the barrier is measured, the ion current can be differentiated to generate a mobility spectrum. Alternatively, the ions can be temporarily stored in the ion guide so that measurement of the ion current of the ions passing over the barrier results in a direct measurement of the mobility spectrum.

摘要翻译： 通过夹带气体中的离子并通过喷嘴绝热地使含离子的气体膨胀以形成气体射流来测量离子迁移率。 具有可变高度的电场屏障位于喷嘴出口处。 场屏障可以位于喷嘴出口附近，或者离子引导件可以位于喷嘴和场屏障之间。 如果提供连续的离子电流，则屏障的高度变化，并且测量通过势垒的离子的离子电流，离子电流可以被微分以产生迁移谱。 或者，离子可以临时存储在离子导向器中，使得通过势垒的离子的离子电流的测量导致对迁移谱的直接测量。

公开(公告)号：US20110186728A1

公开(公告)日：2011-08-04

申请号：US13017803

申请日：2011-01-31

申请人： Jochen Franzen ,  Gökhan Baykut ,  Oliver Räther ,  Carsten Stoermer ,  Evgenij Nikolaev

发明人： Jochen Franzen ,  Gökhan Baykut ,  Oliver Räther ,  Carsten Stoermer ,  Evgenij Nikolaev

IPC分类号： H01J49/02

CPC分类号： H01J49/4205 ,  H01J49/062

摘要： An ion cell having an axis includes a sheath of individual electrodes that extends along the axis and defines an internal volume. Adjacent individual electrodes are electrically insulated from each other. The individual electrodes each receive a DC potential and RF voltage. At least some of the individual electrodes have a width that varies in the axial direction such that an electrical effect on an axis potential varies along the axis of the ion cell.

摘要翻译： 具有轴的离子电池包括沿着轴线延伸并且限定内部体积的各个电极的护套。 相邻的单个电极彼此电绝缘。 各个电极各自接收DC电位和RF电压。 单个电极中的至少一些具有在轴向上变化的宽度，使得轴电位上的电效应沿离子电池的轴线变化。

公开(公告)号：US20060284070A1

公开(公告)日：2006-12-21

申请号：US11440803

申请日：2006-05-25

申请人： Gokhan Baykut ,  Christian Berg ,  Jochen Franzen

发明人： Gokhan Baykut ,  Christian Berg ,  Jochen Franzen

IPC分类号： B01D59/44

CPC分类号： H01J49/38

摘要： The invention relates to methods and devices for regulating the filling level in measuring cells of ion cyclotron resonance mass spectrometers so that it is optimal for mass resolution and mass accuracy. The invention consists in supplying a fraction of the samples to a second reference mass spectrometer operated in parallel, and employing the mass spectra obtained from this reference mass spectrometer to regulate the filling level in the ion cyclotron resonance mass spectrometer.

公开(公告)号：US08384019B2

公开(公告)日：2013-02-26

申请号：US12767273

申请日：2010-04-26

申请人： Claus Köster ,  Jochen Franzen

发明人： Claus Köster ,  Jochen Franzen

IPC分类号： B01D59/44

CPC分类号： H01J49/02 ,  H01J49/26 ,  H01J49/425

摘要： In a Kingdon ion trap in which harmonic ion oscillation in a potential well in a longitudinal direction is completely decoupled from ion oscillation in a direction transverse to the longitudinal direction, ions enter the trap via an entrance tube extending through, but electrically insulated from, one of the Kingdon trap housing electrodes and located outside the minimum of the potential well in the longitudinal direction. The geometry of the Kingdon trap is arranged so that the oscillating ions introduced through the entrance tube cannot return to the entrance tube until they have performed several longitudinal oscillations during which time heavy ions can be introduced into the trap.

摘要翻译： 在Kingdon离子阱中，纵向方向的势阱中的谐波离子振荡在垂直于纵向的方向上与离子振荡完全解耦，离子通过入口管进入陷阱，该入口管延伸通过一个 的Kingdon陷阱壳体电极并且位于纵向方向上的势阱的最小值之外。 Kingdon陷阱的几何形状被布置成使得通过入口管引入的振荡离子不能返回到入口管，直到它们执行几个纵向振荡，在该时间期间可以将重离子引入陷阱。