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公开(公告)号：US20090155870A1
公开(公告)日：2009-06-18
申请号：US12111359
申请日：2008-04-29
申请人： GAIL K. DONALDSON , Andrew C. Eliot , Lori Ann Maggio-Hall , Vasantha Nagarajan , Charles E. Nakamura , Jean-Francois Tomb
发明人： GAIL K. DONALDSON , Andrew C. Eliot , Lori Ann Maggio-Hall , Vasantha Nagarajan , Charles E. Nakamura , Jean-Francois Tomb
CPC分类号： C12N15/63 , C12N9/0006 , C12N9/1205 , C12N9/78 , C12N9/88 , C12P7/16 , C12P7/26 , Y02E50/10
摘要： Methods for the fermentive production of four carbon alcohols are provided. Specifically, butanol, preferably 2-butanol is produced by the fermentive growth of a recombinant bacteria expressing a 2-butanol biosynthetic pathway. The recombinant microorganisms and methods of the invention can also be adapted to produce 2-butanone, an intermediate in the 2-butanol biosynthetic pathways disclosed herein. Specifically disclosed herein are the use of coenzyme B12-independent butanediol dehydratases that catalyzes the substrate to product conversion of 2,3-butanediol to 2-butanone in the process of producing 2-butanol and 2-butanone.
摘要翻译： 提供了发酵生产四种碳醇的方法。 具体地，通过表达2-丁醇生物合成途径的重组细菌的发酵生长来制备丁醇，优选2-丁醇。 本发明的重组微生物和方法也可适用于生产2-丁酮，本文公开的2-丁醇生物合成途径中的中间体。 本文具体公开的是在生产2-丁醇和2-丁酮的过程中催化基质以产生2,3-丁二醇转化为2-丁酮的辅酶B12非依赖性丁二醇脱水酶的用途。
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公开(公告)号：US08828704B2
公开(公告)日：2014-09-09
申请号：US12111359
申请日：2008-04-29
申请人： Gail K. Donaldson , Andrew C. Eliot , Lori Ann Maggio-Hall , Vasantha Nagarajan , Charles E. Nakamura , Jean-Francois Tomb
发明人： Gail K. Donaldson , Andrew C. Eliot , Lori Ann Maggio-Hall , Vasantha Nagarajan , Charles E. Nakamura , Jean-Francois Tomb
CPC分类号： C12N15/63 , C12N9/0006 , C12N9/1205 , C12N9/78 , C12N9/88 , C12P7/16 , C12P7/26 , Y02E50/10
摘要： Methods for the fermentive production of four carbon alcohols are provided. Specifically, butanol, preferably 2-butanol is produced by the fermentive growth of a recombinant bacteria expressing a 2-butanol biosynthetic pathway. The recombinant microorganisms and methods of the invention can also be adapted to produce 2-butanone, an intermediate in the 2-butanol biosynthetic pathways disclosed herein. Specifically disclosed herein are the use of coenzyme B12-independent butanediol dehydratases that catalyzes the substrate to product conversion of 2,3-butanediol to 2-butanone in the process of producing 2-butanol and 2-butanone.
摘要翻译： 提供了发酵生产四种碳醇的方法。 具体地，通过表达2-丁醇生物合成途径的重组细菌的发酵生长来制备丁醇，优选2-丁醇。 本发明的重组微生物和方法也可适用于生产2-丁酮，本文公开的2-丁醇生物合成途径中的中间体。 本文具体公开的是在生产2-丁醇和2-丁酮的过程中催化基质以产生2,3-丁二醇转化为2-丁酮的辅酶B12非依赖性丁二醇脱水酶的用途。
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公开(公告)号：US09068190B2
公开(公告)日：2015-06-30
申请号：US13539125
申请日：2012-06-29
IPC分类号： C12P21/06 , C12P7/16 , C12N9/00 , C12N1/20 , C07H21/04 , C12N15/81 , C12N9/04 , C12N9/02 , C12N9/06 , C12N9/10 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/75 , C12N15/74
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/0008 , C12N9/0016 , C12N9/1022 , C12N9/1096 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/74 , C12N15/746 , C12N15/75 , C12N15/81 , C12Y101/01001 , C12Y101/01002 , C12Y101/01086 , C12Y102/00 , C12Y102/01003 , C12Y102/04004 , C12Y202/01006 , C12Y401/01072 , C12Y402/01009 , Y02E50/10 , Y02E50/343 , Y02P20/52
摘要： Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
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公开(公告)号：US20110112334A1
公开(公告)日：2011-05-12
申请号：US12939315
申请日：2010-11-04
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/0008 , C12N9/0016 , C12N9/1022 , C12N9/1096 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/74 , C12N15/746 , C12N15/75 , C12N15/81 , C12Y101/01001 , C12Y101/01002 , C12Y101/01086 , C12Y102/00 , C12Y102/01003 , C12Y102/04004 , C12Y202/01006 , C12Y401/01072 , C12Y402/01009 , Y02E50/10 , Y02E50/343 , Y02P20/52
摘要： Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
摘要翻译： 提供了发酵生产四种碳醇的方法。 具体地，通过表达异丁醇生物合成途径的重组细菌的发酵生长来生产丁醇，优选异丁醇。
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公开(公告)号：US07993889B1
公开(公告)日：2011-08-09
申请号：US12018216
申请日：2008-01-23
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/0008 , C12N9/0016 , C12N9/1022 , C12N9/1096 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/74 , C12N15/746 , C12N15/75 , C12N15/81 , C12Y101/01001 , C12Y101/01002 , C12Y101/01086 , C12Y102/00 , C12Y102/01003 , C12Y102/04004 , C12Y202/01006 , C12Y401/01072 , C12Y402/01009 , Y02E50/10 , Y02E50/343 , Y02P20/52
摘要： Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
摘要翻译： 提供了发酵生产四种碳醇的方法。 具体地，通过表达异丁醇生物合成途径的重组细菌的发酵生长来生产丁醇，优选异丁醇。
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公开(公告)号：US20110111472A1
公开(公告)日：2011-05-12
申请号：US12939284
申请日：2010-11-04
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/0008 , C12N9/0016 , C12N9/1022 , C12N9/1096 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/74 , C12N15/746 , C12N15/75 , C12N15/81 , C12Y101/01001 , C12Y101/01002 , C12Y101/01086 , C12Y102/00 , C12Y102/01003 , C12Y102/04004 , C12Y202/01006 , C12Y401/01072 , C12Y402/01009 , Y02E50/10 , Y02E50/343 , Y02P20/52
摘要： Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
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公开(公告)号：US07851188B2
公开(公告)日：2010-12-14
申请号：US11586315
申请日：2006-10-25
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/0008 , C12N9/0016 , C12N9/1022 , C12N9/1096 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/74 , C12N15/746 , C12N15/75 , C12N15/81 , C12Y101/01001 , C12Y101/01002 , C12Y101/01086 , C12Y102/00 , C12Y102/01003 , C12Y102/04004 , C12Y202/01006 , C12Y401/01072 , C12Y402/01009 , Y02E50/10 , Y02E50/343 , Y02P20/52
摘要： Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
摘要翻译： 提供了发酵生产四种碳醇的方法。 具体地，通过表达异丁醇生物合成途径的重组细菌的发酵生长来生产丁醇，优选异丁醇。
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公开(公告)号：US08951774B2
公开(公告)日：2015-02-10
申请号：US12939315
申请日：2010-11-04
IPC分类号： C12P21/06 , C12P7/04 , C12N1/20 , C12N1/00 , C12N15/00 , C07H21/04 , C12N15/81 , C12N9/04 , C12N9/02 , C12N9/06 , C12N9/10 , C12N9/88 , C12N15/52 , C12P7/16 , C12N15/70 , C12N15/75 , C12N15/74
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/0008 , C12N9/0016 , C12N9/1022 , C12N9/1096 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/74 , C12N15/746 , C12N15/75 , C12N15/81 , C12Y101/01001 , C12Y101/01002 , C12Y101/01086 , C12Y102/00 , C12Y102/01003 , C12Y102/04004 , C12Y202/01006 , C12Y401/01072 , C12Y402/01009 , Y02E50/10 , Y02E50/343 , Y02P20/52
摘要： Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
摘要翻译： 提供了发酵生产四种碳醇的方法。 具体地，通过表达异丁醇生物合成途径的重组细菌的发酵生长来生产丁醇，优选异丁醇。
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公开(公告)号：US20110301388A1
公开(公告)日：2011-12-08
申请号：US13205351
申请日：2011-08-08
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/0008 , C12N9/0016 , C12N9/1022 , C12N9/1096 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/74 , C12N15/746 , C12N15/75 , C12N15/81 , C12Y101/01001 , C12Y101/01002 , C12Y101/01086 , C12Y102/00 , C12Y102/01003 , C12Y102/04004 , C12Y202/01006 , C12Y401/01072 , C12Y402/01009 , Y02E50/10 , Y02E50/343 , Y02P20/52
摘要： Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
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公开(公告)号：US08273558B2
公开(公告)日：2012-09-25
申请号：US12966333
申请日：2010-12-13
摘要： Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
摘要翻译： 提供了发酵生产四种碳醇的方法。 具体地，通过表达异丁醇生物合成途径的重组细菌的发酵生长来生产丁醇，优选异丁醇。
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