公开(公告)号：US20170153210A1

公开(公告)日：2017-06-01

申请号：US15116940

申请日：2015-02-13

Applicant: GE Healthcare Bio-Sciences AB

Inventor： Christer Olof ERIKSSON ,  Nils NORRMAN

IPC: G01N30/04 ,  B01D15/34 ,  G01N30/46 ,  B01D15/38 ,  B01D15/12 ,  B01D15/20 ,  B01D15/18 ,  B01D15/16

CPC classification number: G01N30/04 ,  B01D15/125 ,  B01D15/16 ,  B01D15/1871 ,  B01D15/1885 ,  B01D15/203 ,  B01D15/34 ,  B01D15/3804 ,  B01D15/3809 ,  G01N30/461 ,  G01N30/468 ,  G01N2030/8831

Abstract: Automated two step chromatography purification system comprising a, system controller, a capture flow path comprising at least one pump, an elution flow path comprising at least one pump, and a valve arrangement for selective connection of two capture columns to the capture flow path and the elution flow path respectively such that both flow paths may be operated simultaneously and in parallel.

公开(公告)号：US20150360232A1

公开(公告)日：2015-12-17

申请号：US14764919

申请日：2014-01-29

Applicant: GE HEALTHCARE BIO-SCIENCES AB

Inventor： Nils NORRMAN ,  Pierre LE GREVES

IPC: B03C1/02 ,  C02F1/48

CPC classification number: B03C1/02 ,  B01D11/0419 ,  B01D11/0423 ,  B01D15/3885 ,  B01J20/24 ,  B01J20/261 ,  B01J20/28009 ,  B01J20/3204 ,  B01J20/3227 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/3289 ,  B01J20/3293 ,  B01J2220/64 ,  B03C1/00 ,  B03C1/01 ,  C02F1/48 ,  C02F2101/308 ,  C07K1/14 ,  H01F1/445

Abstract: A method for purifying a substance in a solution in a simple streamlined process using a magnetic porous particle. For easy small scale purification of a substance, the magnetic porous particle is coated with either a hydrophilic or hydrophobic liquid and transferred into a second liquid containing the substance under conditions which allow said substance to partition into the first liquid within said magnetic porous particle. Finally the magnetic porous particle is removed from said second liquid, wherein the first and second liquid are substantially immiscible and the partition coefficient P of the substance between the first and second liquid is greater than 1.

Abstract translation: 使用磁性多孔颗粒以简单的流线型方法纯化溶液中的物质的方法。 为了容易地小规模地纯化物质，磁性多孔颗粒用亲水或疏水液体涂覆，并在允许所述物质分配到所述磁性多孔颗粒内的第一液体的条件下转移到含有物质的第二液体中。 最后，从所述第二液体中除去磁性多孔颗粒，其中第一和第二液体基本上是不混溶的，并且第一和第二液体之间物质的分配系数P大于1。