公开(公告)号：US20190111419A1

公开(公告)日：2019-04-18

申请号：US16090609

申请日：2017-03-30

Applicant: GE HEALTHCARE BIOPROCESS R&D AB

Inventor： Jean-Luc Maloisel ,  Tobias Söderman ,  Ola Lind ,  Ida Eklind

IPC: B01J47/02 ,  B01J39/07 ,  B01J39/19 ,  B01J39/26 ,  B01J41/07 ,  B01J41/13 ,  B01J41/20 ,  C07K1/18 ,  B01D15/36 ,  B01D15/38 ,  B01D15/32

Abstract: The invention discloses a separation matrix for purification of biomacromolecules, comprising a plurality of particles (1) having a core region (2) and a shell region (3), wherein: a) said shell region is accessible to a target biomacromolecule; b) said core region is less accessible to the target biomacromolecule than the shell region; and c) the core region comprises a grafted polymer comprising residues of at least one polymerizable monomer.

公开(公告)号：US20180127459A1

公开(公告)日：2018-05-10

申请号：US15564224

申请日：2016-04-04

Applicant: GE HEALTHCARE BIOPROCESS R&D AB

Inventor： Martin Hall ,  Mikael Berg ,  Ida Eklind ,  Sandeep Kristiansson

IPC: C07K1/18 ,  C07K14/755 ,  A61P7/00 ,  B01D15/36

CPC classification number: C07K1/18 ,  A61K38/00 ,  A61P7/00 ,  B01D15/363 ,  C07K14/755

Abstract: The present invention relates to the field of chromatography. More closely, the invention relates to a chromatographic method for purification of Factor VIII and von Willebrand factor from a cryoprecipitate of plasma. The chromatographic method is performed on a matrix comprising an inner porous core and outer porous lid surrounding said core.