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    Probe assembly
    4.
    发明授权
    Probe assembly 有权

    公开(公告)号：US09891080B2

    公开(公告)日：2018-02-13

    申请号：US14353344

    申请日：2012-10-28

    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.

    Inventor： Richard L. Damren ,  Colin R. Tuohey ,  Thomas Erdenberger ,  Michael Fisher ,  Jonathan A. Kenney ,  Parrish M. Galliher ,  Joseph D. Crowell

    IPC: G01D11/24 ,  A61M39/18

    CPC classification number: G01D11/24 ,  A61M39/18

    Abstract: A probe assembly for inserting a probe into a flexible or semi-rigid vessel or tubing having a distal aseptic connector for coupling to the vessel or tubing, the probe sheath comprising at least a portion that is rigid, the probe sheath extending longitudinally from the aseptic connector and having at least one inner longitudinal lumen configured to receive an elongate sensor or probe body and to permit longitudinal movement of the sensor/probe body within the probe sheath lumen, and an actuator for deploying a probe within the vessel or tubing by advancing the probe body through the aseptic connector to a position where the probe can measure at least one parameter within the vessel or tubing is disclosed herein.

    Drain down and re-feed of microcarrier bioreactor
    6.
    发明授权
    Drain down and re-feed of microcarrier bioreactor 有权

    公开(公告)号：US09932562B2

    公开(公告)日：2018-04-03

    申请号：US14054461

    申请日：2013-10-15

    Applicant: GE Healthcare Bio-Sciences Corp.

    Inventor： Patrick M. Guertin ,  Joseph D. Crowell

    IPC: C12N7/00 ,  C12M1/12 ,  C12M1/00

    CPC classification number: C12N7/00 ,  C12M25/14 ,  C12M47/10 ,  C12N2770/24151

    Abstract: The invention provides a method of increasing product yield per culture in a population of product-secreting cells bound to a scaffold, for example, a microcarrier, at least partially immersed in a culture medium in a bioreactor. The method comprising: semi-harvesting product by removing a volume of the culture medium with a first-secreted product concentration while leaving the scaffold with the bound cells in the bioreactor; re-feeding the cells by adding a fresh culture medium to increase the culture medium in the bioreactor to approximately the original volume; agitating the culture medium to allow the cells to grow and release a second-secreted product concentration; harvesting product by removing the culture medium with the second-secreted product concentration while leaving the scaffold with the bound cells behind. Also disclosed is a method of increasing virus yield per culture in a population of virus-infected cells bound to a microcarrier suspended in a culture medium.

    PROBE ASSEMBLY
    7.
    发明申请
    PROBE ASSEMBLY 有权
    探测组件

    公开(公告)号：US20140260712A1

    公开(公告)日：2014-09-18

    申请号：US14353344

    申请日：2012-10-28

    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.

    Inventor： Richard L. Damren ,  Colin R. Tuohey ,  Thomas Erdenberger ,  Michael Fisher ,  Jonathan A. Kenney ,  Parrish M. Galliher ,  Joseph D. Crowell

    IPC: G01D11/24

    CPC classification number: G01D11/24 ,  A61M39/18

    Abstract: A probe assembly for inserting a probe into a flexible or semi-rigid vessel or tubing having a distal aseptic connector for coupling to the vessel or tubing, the probe sheath comprising at least a portion that is rigid, the probe sheath extending longitudinally from the aseptic connector and having at least one inner longitudinal lumen configured to receive an elongate sensor or probe body and to permit longitudinal movement of the sensor/probe body within the probe sheath lumen, and an actuator for deploying a probe within the vessel or tubing by advancing the probe body through the aseptic connector to a position where the probe can measure at least one parameter within the vessel or tubing is disclosed herein.

    Abstract translation: 探针组件，用于将探针插入到具有远端无菌连接器的柔性或半刚性容器或管道中，所述远端无菌连接器用于联接到容器或管道，所述探针护套包括至少一部分刚性部分，探针护套从无菌 连接器，并且具有至少一个内部纵向内腔，其构造成接收细长的传感器或探针主体并且允许传感器/探针主体在探针鞘腔内的纵向移动;以及致动器，用于通过推进 探针本体通过无菌连接器到达探针可以测量容器或管道内的至少一个参数的位置。

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