公开(公告)号：US10265697B2

公开(公告)日：2019-04-23

申请号：US15292093

申请日：2016-10-12

Applicant: GE Healthcare BioProcess R&D AB

Inventor： Karol Lacki

IPC: B01L3/00 ,  G01N30/60 ,  G01N30/46 ,  G01N30/86

Abstract: A micro titre plate comprising a number of wells filled with separation matrix. According to the invention the volume of the separation matrix is varied between at least some of the wells.

公开(公告)号：US20170056877A1

公开(公告)日：2017-03-02

申请号：US15292093

申请日：2016-10-12

Applicant: GE Healthcare BioProcess R&D AB

Inventor： Karol Lacki

IPC: B01L3/00 ,  G01N30/60 ,  G01N30/46

CPC classification number: B01L3/50255 ,  B01L3/5085 ,  B01L2300/069 ,  G01N30/466 ,  G01N30/6043 ,  G01N30/8658 ,  Y10T436/25

Abstract: A micro titre plate comprising a number of wells filled with separation matrix. According to the invention the volume of the separation matrix is varied between at least some of the wells.

Abstract translation: 包含多个填充有分离基质的孔的微量滴定板。 根据本发明，分离基质的体积在至少一些孔之间变化。

公开(公告)号：US20160367966A1

公开(公告)日：2016-12-22

申请号：US15120845

申请日：2015-02-18

Applicant: GE HEALTHCARE BIOPROCESS R&D AB

Inventor： Jean-Luc Maloisel ,  Karolina Busson ,  Karol Lacki ,  Bjorn Noren ,  Helena Skoglar

IPC: B01J20/32 ,  B01J20/28 ,  B01D15/20 ,  B01D15/30 ,  C12N1/20 ,  B01D15/12 ,  C07K1/22 ,  C07K14/765 ,  C07K14/77 ,  B01J20/286 ,  B01D15/36

CPC classification number: B01J20/3293 ,  B01D15/125 ,  B01D15/203 ,  B01D15/305 ,  B01D15/363 ,  B01J20/28019 ,  B01J20/286 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3248 ,  B01J20/327 ,  B01J20/3278 ,  C07K1/22 ,  C07K14/765 ,  C07K14/77 ,  C12N1/20

Abstract: The invention discloses a separation matrix for purification of biological particles, comprising a plurality of particles having a porous core entity and a porous shell entity covering the core entity, wherein the core entity comprises at least 50 micromole/ml primary amines present on covalently attached ligands displaying at least two primary amines per ligand and the shell entity comprises less than 20 micromole/ml primary amines The invention further discloses a method of purifying biological particles and a method of manufacturing a separation matrix.

Abstract translation: 本发明公开了一种用于纯化生物颗粒的分离基质，其包含多个具有多孔核心实体和覆盖核心实体的多孔壳体的颗粒，其中核心实体包含共价连接的配体上存在的至少50微摩尔/ 每个配体显示至少两个伯胺，壳体包含少于20微摩尔/ ml伯胺本发明还公开了一种纯化生物颗粒的方法和一种制备分离基质的方法。