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公开(公告)号：US20030003546A1
公开(公告)日：2003-01-02
申请号：US09816744
申请日：2001-03-22
Applicant: GENENTECH, INC.
Inventor： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC: C12Q001/68 , C12P021/02 , C07H021/04 , C12N005/06 , A61K038/20
Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
Abstract translation: 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。
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公开(公告)号：US20030186306A1
公开(公告)日：2003-10-02
申请号：US10410374
申请日：2003-04-08
Applicant: Genentech, Inc.
Inventor： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul J. Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC: C12Q001/68 , G01N033/53 , C07H021/04 , C12P021/02 , C12N005/06 , C07K014/47
CPC classification number: C07K14/705 , A61K38/00 , C07K14/54 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N2500/04
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20030180255A1
公开(公告)日：2003-09-25
申请号：US10410927
申请日：2003-04-09
Applicant: Genentech, Inc.
Inventor： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC: C07K014/54 , A61K038/20 , C07H021/04 , C12P021/04 , C12N005/06
Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
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公开(公告)号：US20020102706A1
公开(公告)日：2002-08-01
申请号：US09887879
申请日：2001-06-21
Applicant: Genentech, Inc.
Inventor： Avi J. Ashkenazi , Kevin P. Baker , Anan Chuntharapai , Austin Gurney , Kyung Jin Kim , William I. Wood
IPC: C12N009/64 , C12P021/02 , C12N005/06
CPC classification number: C07K14/47 , A01K2217/05 , A61K38/00 , A61K2039/505 , C07K14/4747 , C07K14/70578 , C07K16/2878 , C07K2319/00 , G01N33/57484 , G01N33/68
Abstract: Novel polypeptides, designated Apo-2DcR, which are capable of binding Apo-2 ligand are provided. Compositions including Apo-2DcR chimeras, nucleic acid encoding Apo-2DcR, and antibodies to Apo-2DcR are also provided.
Abstract translation: 提供了能够结合Apo-2配体的新型多肽，称为Apo-2DcR。 还提供了包含Apo-2DcR嵌合体，编码Apo-2DcR的核酸和Apo-2DcR抗体的组合物。
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公开(公告)号：US20030203451A1
公开(公告)日：2003-10-30
申请号：US10458442
申请日：2003-06-10
Applicant: Genentech, Inc.
Inventor： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC: C12P021/02 , C12N005/06 , C07K014/47 , C07K016/18 , C07H021/04 , C12N009/00
CPC classification number: A61K38/20 , C07K14/54 , C07K14/7155 , C07K2319/30 , C12N15/1136 , C12N2310/11 , C12N2310/12 , C12N2310/15
Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
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Patent Agency Ranking
公开(公告)号：US20030138915A1
公开(公告)日：2003-07-24
申请号：US10242383
申请日：2002-09-11
Applicant: Genentech, Inc.
Inventor： Avi J. Ashkenazi , Kevin P. Baker , Anan Chuntharapai , Austin Gurney , Kyung Jin Kim , William I. Wood
IPC: C07K014/775 , C07H021/04 , C12P021/02 , C12N005/06
CPC classification number: C07K14/47 , A01K2217/05 , A61K38/00 , A61K2039/505 , C07K14/4747 , C07K14/70578 , C07K16/2878 , C07K2319/00 , G01N33/57484 , G01N33/68
Abstract: Novel polypeptides, designated Apo-2DcR, which are capable of binding Apo-2 ligand are provided. Compositions including Apo-2DcR chimeras, nucleic acid encoding Apo-2DcR, and antibodies to Apo-2DcR are also provided.
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公开(公告)号：US20030087387A1
公开(公告)日：2003-05-08
申请号：US10235767
申请日：2002-09-05
Applicant: Genentech, Inc.
Inventor： Austin Gurney
IPC: C07K016/28 , C07K014/705 , C07H021/04 , C12P021/02 , C12N005/06
CPC classification number: C07K14/47 , A61K38/00 , C07K14/705 , C07K2319/00 , C07K2319/30 , G01N33/57484 , G01N33/68
Abstract: The invention relates to the identification and isolation of novel DNAs encoding the human Toll proteins PRO285 and PRO286, and to methods and means for the recombinant production of these proteins. The invention also concerns antibodies specifically binding the PRO285 or PR0286 Toll protein.
Abstract translation: 本发明涉及鉴定和分离编码人Toll蛋白PRO285和PRO286的新型DNA，以及重组生产这些蛋白质的方法和手段。 本发明还涉及特异性结合PRO285或PR0286 Toll蛋白的抗体。
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公开(公告)号：US20020177188A1
公开(公告)日：2002-11-28
申请号：US09874503
申请日：2001-06-05
Applicant: GENENTECH, INC.
Inventor： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starvovasnik , Menno Van Lookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel G. Yansura
IPC: C07K014/715 , C07H021/04 , C12P021/02 , C12N005/06
CPC classification number: C07H21/04 , C07K14/715 , C12N5/06 , C12P21/02
Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
Abstract translation: 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。
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9.发明申请Novel tumor necrosis factor receptor homolog and nucleic acids encoding the same 审中-公开新型肿瘤坏死因子受体同源物和核酸编码相同公开(公告)号：US20020150993A1
公开(公告)日：2002-10-17
申请号：US10116378
申请日：2002-04-04
Applicant: Genentech, Inc.
Inventor： Avi J. Ashkenazi , Audrey Goddard , Austin Gurney , Scot A. Marsters , Robert M. Pitti , William I. Wood
IPC: A61K038/17 , C07H021/04 , C12P021/02 , C12N005/06 , C07K014/715
CPC classification number: C07K14/70578 , A61K38/00 , C07K14/4747 , C07K14/70575 , C07K2319/00 , C12N2799/026
Abstract: The present invention is directed to novel polypeptides having homology to members of the tumor necrosis factor receptor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Abstract translation: 本发明涉及与肿瘤坏死因子受体家族的成员具有同源性的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US20040043397A1
公开(公告)日：2004-03-04
申请号：US10408385
申请日：2003-04-07
Applicant: Genentech, Inc.
Inventor： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC: C12Q001/68 , C07H021/04 , C12P021/02 , C12N005/06 , C07K014/47 , C07K016/18
CPC classification number: C07K14/54
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Abstract translation: 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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