公开(公告)号：US09994646B2

公开(公告)日：2018-06-12

申请号：US14735024

申请日：2015-06-09

Applicant: Genentech, Inc.

Inventor： Erin H. Christensen ,  Dan L. Eaton ,  Andrew C. Vendel ,  Bernd Wranik

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/32

CPC classification number: C07K16/468 ,  C07K16/283 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/53 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/73

Abstract: The invention provides engineered protein complexes constructed using a coiled coil and/or a tether and methods for making, using, and purifying such complexes, such as multispecific antibodies or other multispecific Fc containing complexes.

公开(公告)号：US20170362318A1

公开(公告)日：2017-12-21

申请号：US15406583

申请日：2017-01-13

Applicant: GENENTECH, INC.

Inventor： Craig Crowley ,  Frederic J. De Sauvage ,  Dan L. Eaton ,  Allen Ebens, JR. ,  Kristi Elkins ,  Jo-Anne S. Hongo ,  Jagath Reddy Junutula ,  Andrew Polson ,  Sarajane Ross ,  Victoria Smith ,  Richard L. Vandlen ,  Bing Zheng

IPC: C07K16/28 ,  G01N33/574 ,  C07K16/30 ,  A61K47/68 ,  C07K14/705 ,  A61K38/00 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K38/00 ,  A61K47/6817 ,  A61K47/6851 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/624 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/574

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US09688758B2

公开(公告)日：2017-06-27

申请号：US14455189

申请日：2014-08-08

Applicant: Genentech, Inc.

Inventor： Bernd Wranik ,  Dan L. Eaton ,  Erin H. Christensen ,  Jiansheng Wu

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/28 ,  C07K16/18 ,  C07K16/22 ,  C07K16/24 ,  C07K16/26

CPC classification number: C07K16/28 ,  C07K16/00 ,  C07K16/18 ,  C07K16/22 ,  C07K16/24 ,  C07K16/26 ,  C07K2317/31 ,  C07K2317/515 ,  C07K2317/53 ,  C07K2317/622 ,  C07K2317/64

Abstract: The invention provides engineered heteromultimeric protein complexes constructed using one, two, or three tethers and methods for making, using, and purifying such complexes, such as antibodies with different binding properties.