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Patent Agency Ranking
1.发明申请SUBSTRATES AND METHODS FOR COLLECTION, STABILIZATION AND ELUTION OF BIOMOLECULES 审中-公开生物分子收集，稳定和提取的基质和方法公开(公告)号：US20170021333A1
公开(公告)日：2017-01-26
申请号：US15285986
申请日：2016-10-05
Applicant: General Electric Company
Inventor： Ernest William Kovacs , Frank John Mondello , Erik Leeming Kvam , Bing LI
IPC: B01J20/28 , C12N9/38 , C07K14/775 , C07K1/16 , C07K14/54 , C07K14/525 , C07K1/14 , B01J20/24 , C07K14/545
CPC classification number: B01J20/28038 , B01J20/22 , B01J20/24 , B01J20/28033 , B01J20/3212 , B01J20/3242 , B01J20/3246 , C07K1/145 , C07K1/16 , C07K14/525 , C07K14/5421 , C07K14/545 , C07K14/775 , C12N9/2471 , C12N15/1006 , C12N15/1017 , C12Y302/01023
Abstract: A solid substrate for the extraction, stabilization, and storage of proteins is provided. The substrate includes: a polysaccharide, such as melezitose under a substantially dry state. The substrate is configured to extract proteins from a sample and stabilize the extracted proteins in a dry format under ambient conditions for a prolonged period of time. Methods for collecting and recovering the proteins stored in the dry solid substrate are also described.
Abstract translation: 提供了用于提取，稳定和储存蛋白质的固体底物。 底物包括：多糖，例如基本干燥状态下的松三草。 底物被配置为从样品中提取蛋白质并在环境条件下以干燥形式稳定所提取的蛋白质较长时间。 还描述了收集和回收储存在干固体基质中的蛋白质的方法。
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公开(公告)号：US20160146802A1
公开(公告)日：2016-05-26
申请号：US14548383
申请日：2014-11-20
Applicant: General Electric Company
Inventor： Bing Li , Brian Christopher Bales , David Roger Moore , Jason Michael Nichols , Cathryn Ellen Olsen , William Christopher Alberts , Frank John Mondello
IPC: G01N33/543 , G01N33/548 , G01N33/558
CPC classification number: G01N33/54386 , G01N33/54353 , G01N33/548 , G01N33/558
Abstract: A device comprising a modified porous membrane is provided. The modified porous membrane comprises a polymer coating grafted to a porous membrane. The device is used for analyte detection from a biological sample using an immunoassay. The device comprises a sample application zone at one end of the device for applying a biological sample comprising a target analyte; and a detection zone present at another end of the device, downstream of the sample application zone for detecting the target analyte, wherein the detection zone comprises one or more first biomolecules immobilized on a modified porous membrane having a structure of Formula (I).
Abstract translation: 提供了包含改性多孔膜的装置。 改性多孔膜包括接枝到多孔膜上的聚合物涂层。 该装置用于使用免疫测定从生物样品进行分析物检测。 该装置包括用于施加包含目标分析物的生物样品的装置的一端处的样品施加区域; 以及位于所述装置的另一端的检测区，其位于所述样品施加区的下游，用于检测所述目标分析物，其中所述检测区包含固定在具有式（I）的结构的改性多孔膜上的一个或多个第一生物分子。
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3.发明授权Substrates and methods for collection, stabilization and elution of biomolecules 有权用于收集，稳定和洗脱生物分子的底物和方法公开(公告)号：US09480966B2
公开(公告)日：2016-11-01
申请号：US14261900
申请日：2014-04-25
Applicant: General Electric Company
Inventor： Ernest William Kovacs , Erik Leeming Kvam , Bing Li , Frank John Mondello
CPC classification number: B01J20/28038 , B01J20/22 , B01J20/24 , B01J20/28033 , B01J20/3212 , B01J20/3242 , B01J20/3246 , C07K1/145 , C07K1/16 , C07K14/525 , C07K14/5421 , C07K14/545 , C07K14/775 , C12N9/2471 , C12N15/1006 , C12N15/1017 , C12Y302/01023
Abstract: A solid substrate for the extraction, stabilization, and storage of proteins is provided. The substrate includes: a polysaccharide, such as melezitose under a substantially dry state. The substrate is configured to extract proteins from a sample and stabilize the extracted proteins in a dry format under ambient conditions for a prolonged period of time. Methods for collecting and recovering the proteins stored in the dry solid substrate are also described.
Abstract translation: 提供了用于提取，稳定和储存蛋白质的固体底物。 底物包括：多糖，例如基本干燥状态下的松三草。 底物被配置为从样品中提取蛋白质并在环境条件下以干燥形式稳定所提取的蛋白质较长时间。 还描述了收集和回收储存在干固体基质中的蛋白质的方法。
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公开(公告)号：US20160146795A1
公开(公告)日：2016-05-26
申请号：US14548338
申请日：2014-11-20
Applicant: General Electric Company
Inventor： Bing Li , Brian Christopher Bales , David Roger Moore , Jason Michael Nichols , Cathryn Ellen Olsen , William Christopher Alberts , Frank John Mondello
IPC: G01N33/548
CPC classification number: G01N33/548 , B01D67/009 , B01D69/144 , B01D71/78 , G01N33/54353 , Y02A50/57
Abstract: A modified porous membrane comprising a polymer coating grafted to a porous membrane is described. A method for analyte detection from a biological sample using an immunoassay is also provided using the modified membrane, wherein the method comprises a) providing a modified porous membrane having the structure of Formula (I), b) incubating the modified porous membrane with a first biomolecule, wherein the first biomolecule binds to the modified porous membrane to form a first biomolecule bound modified porous membrane; and c) adding a biological sample comprising at least an analyte to the first biomolecule bound modified porous membrane for analyte detection by binding the analyte to the first biomolecule bound to the modified porous membrane.
Abstract translation: 描述了包含接枝到多孔膜上的聚合物涂层的改性多孔膜。 还提供了使用免疫测定法从生物样品中分析物检测的方法，其中所述方法包括：a）提供具有式（I）结构的改性多孔膜，b）将所述改性多孔膜与第一 生物分子，其中所述第一生物分子与修饰的多孔膜结合以形成第一生物分子结合的改性多孔膜; 和c）将包含至少一种分析物的生物样品添加到第一生物分子结合的改性多孔膜上，以通过将分析物结合到与修饰的多孔膜结合的第一生物分子来进行分析物检测。
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5.发明申请SUBSTRATES AND METHODS FOR COLLECTION, STABILIZATION AND ELUTION OF BIOMOLECULES 有权生物分子收集，稳定和提取的基质和方法公开(公告)号：US20140234942A1
公开(公告)日：2014-08-21
申请号：US14261900
申请日：2014-04-25
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Ernest William Kovacs , Erik Leeming Kvam , Bing Li , Frank John Mondello
CPC classification number: B01J20/28038 , B01J20/22 , B01J20/24 , B01J20/28033 , B01J20/3212 , B01J20/3242 , B01J20/3246 , C07K1/145 , C07K1/16 , C07K14/525 , C07K14/5421 , C07K14/545 , C07K14/775 , C12N9/2471 , C12N15/1006 , C12N15/1017 , C12Y302/01023
Abstract: A solid substrate for the extraction, stabilization, and storage of proteins is provided. The substrate includes: a polysaccharide, such as melezitose under a substantially dry state. The substrate is configured to extract proteins from a sample and stabilize the extracted proteins in a dry format under ambient conditions for a prolonged period of time. Methods for collecting and recovering the proteins stored in the dry solid substrate are also described.
Abstract translation: 提供了用于提取，稳定和储存蛋白质的固体底物。 底物包括：多糖，例如基本干燥状态下的松三草。 底物被配置为从样品中提取蛋白质并在环境条件下以干燥形式稳定所提取的蛋白质较长时间。 还描述了收集和回收储存在干固体基质中的蛋白质的方法。
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