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    DEVICE FOR RAPID DIAGNOSTIC TESTS TO DETECT ANTIGENS WITH IMPROVED SENSITIVITY
    1.
    发明申请
    DEVICE FOR RAPID DIAGNOSTIC TESTS TO DETECT ANTIGENS WITH IMPROVED SENSITIVITY 审中-公开

    公开(公告)号：US20170212108A1

    公开(公告)日：2017-07-27

    申请号：US15401333

    申请日：2017-01-09

    Applicant: General Electric Company ,  TOKITAE LLC

    Inventor： Bing Li ,  Matthew Jeremiah Misner ,  David Roger Moore ,  Kevin Paul Flood Nichols ,  David Cate ,  Matthew F. Rosen

    IPC: G01N33/558 ,  G01N33/543

    CPC classification number: G01N33/558 ,  G01N33/54386

    Abstract: A rapid diagnostic testing device for testing of a biological sample is provided. The device comprises a channeled construct, at least one lateral flow unit, and a cassette housing. The channeled construct is configured to receive a biological sample to form at least partially purified biological sample. The lateral flow unit is at least partially disposed in the cassette housing. The lateral flow unit comprises: a sample receiving zone, a conjugate zone and a detection zone. The sample receiving zone is operatively coupled to the channeled construct for receiving the partially purified biological sample comprising at least one analyte. The conjugate zone comprising a conjugate particle to bind the analyte is disposed adjacent to the first side of the sample receiving zone. The detection zone is disposed adjacent to the second side of the sample receiving zone and comprises at least one binding agent for detecting the analyte.

    POROUS MEMBRANES WITH A POLYMER GRAFTING, METHODS AND USES THEREOF
    3.
    发明申请
    POROUS MEMBRANES WITH A POLYMER GRAFTING, METHODS AND USES THEREOF 审中-公开
    多孔膜与聚合物接枝，其方法和用途

    公开(公告)号：US20160146795A1

    公开(公告)日：2016-05-26

    申请号：US14548338

    申请日：2014-11-20

    Applicant: General Electric Company

    Inventor： Bing Li ,  Brian Christopher Bales ,  David Roger Moore ,  Jason Michael Nichols ,  Cathryn Ellen Olsen ,  William Christopher Alberts ,  Frank John Mondello

    IPC: G01N33/548

    CPC classification number: G01N33/548 ,  B01D67/009 ,  B01D69/144 ,  B01D71/78 ,  G01N33/54353 ,  Y02A50/57

    Abstract: A modified porous membrane comprising a polymer coating grafted to a porous membrane is described. A method for analyte detection from a biological sample using an immunoassay is also provided using the modified membrane, wherein the method comprises a) providing a modified porous membrane having the structure of Formula (I), b) incubating the modified porous membrane with a first biomolecule, wherein the first biomolecule binds to the modified porous membrane to form a first biomolecule bound modified porous membrane; and c) adding a biological sample comprising at least an analyte to the first biomolecule bound modified porous membrane for analyte detection by binding the analyte to the first biomolecule bound to the modified porous membrane.

    Abstract translation: 描述了包含接枝到多孔膜上的聚合物涂层的改性多孔膜。 还提供了使用免疫测定法从生物样品中分析物检测的方法，其中所述方法包括：a）提供具有式（I）结构的改性多孔膜，b）将所述改性多孔膜与第一 生物分子，其中所述第一生物分子与修饰的多孔膜结合以形成第一生物分子结合的改性多孔膜; 和c）将包含至少一种分析物的生物样品添加到第一生物分子结合的改性多孔膜上，以通过将分析物结合到与修饰的多孔膜结合的第一生物分子来进行分析物检测。

    ELECTROSPUN FIBERS FOR PROTEIN STABLIZIATION AND STORAGE
    4.
    发明申请
    ELECTROSPUN FIBERS FOR PROTEIN STABLIZIATION AND STORAGE 审中-公开
    用于蛋白质稳定和储存的电纺纤维

    公开(公告)号：US20150176056A1

    公开(公告)日：2015-06-25

    申请号：US14140127

    申请日：2013-12-24

    Applicant: General Electric Company

    Inventor： Bing Li ,  David Roger Moore ,  William Christopher Alberts ,  John Richard Nelson

    IPC: C12Q1/68 ,  G01N33/543

    CPC classification number: C12Q1/6806 ,  G01N33/54346 ,  G01N33/54393

    Abstract: An electrospinning approach is disclosed for generating a dissolvable formulation of a reagent of interest in a nanoscale fiber medium. In one embodiment, the nanoscale fibers can incorporate and stabilize biological agents of interest, such as for storage at room temperature for extended periods. In one implementation, the fibers can be produced in a continuous manner and dissolve rapidly.

    Abstract translation: 公开了一种静电纺丝方法，用于在纳米级纤维介质中产生感兴趣的试剂的可溶性制剂。 在一个实施方案中，纳米级纤维可以掺入并稳定感兴趣的生物试剂，例如在室温下长时间储存​​。 在一个实施方案中，纤维可以以连续的方式生产并迅速溶解。

    Device for rapid diagnostic tests to detect antigens with improved sensitivity
    5.
    发明授权
    Device for rapid diagnostic tests to detect antigens with improved sensitivity 有权

    公开(公告)号：US10983119B2

    公开(公告)日：2021-04-20

    申请号：US15401333

    申请日：2017-01-09

    Applicant: General Electric Company ,  TOKITAE LLC

    Inventor： Bing Li ,  Matthew Jeremiah Misner ,  David Roger Moore ,  Kevin Paul Flood Nichols ,  David Cate ,  Matthew F Rosen

    IPC: G01N33/558 ,  G01N33/543

    Abstract: A rapid diagnostic testing device for testing of a biological sample is provided. The device comprises a channeled construct, at least one lateral flow unit, and a cassette housing. The channeled construct is configured to receive a biological sample to form at least partially purified biological sample. The lateral flow unit is at least partially disposed in the cassette housing. The lateral flow unit comprises: a sample receiving zone, a conjugate zone and a detection zone. The sample receiving zone is operatively coupled to the channeled construct for receiving the partially purified biological sample comprising at least one analyte. The conjugate zone comprising a conjugate particle to bind the analyte is disposed adjacent to the first side of the sample receiving zone. The detection zone is disposed adjacent to the second side of the sample receiving zone and comprises at least one binding agent for detecting the analyte.

    Substrates and associated methods for elution of nucleic acids
    6.
    发明授权
    Substrates and associated methods for elution of nucleic acids 有权
    底物和相关的核酸洗脱方法

    公开(公告)号：US09534214B2

    公开(公告)日：2017-01-03

    申请号：US14068633

    申请日：2013-10-31

    Applicant: General Electric Company

    Inventor： Bing Li ,  Gregory Andrew Grossmann ,  Erik Leeming Kvam ,  Brian Christopher Bales ,  Jason Louis Davis

    IPC: C12N15/10 ,  B01J20/22 ,  B01J20/26

    CPC classification number: C12N15/1006 ,  B01J20/22 ,  B01J20/261 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3255 ,  B01J20/3274 ,  C12N15/1017

    Abstract: A solid substrate for biological sample storage under dry-state and elution of biomolecules is provided. The dry, solid substrate is coated with saccharides, such as monosaccharides, oligosaccharides, polysaccharides or combinations thereof, and the substrate is comprised of one or more protein denaturing agents impregnated therein under a substantially dry state. A method for elution of biomolecules from biological samples is also provided. The compositions disclosed herein provide for enhanced elution and recovery of biomolecules, such as nucleic acids, from the sample. The sample is disposed on a substrate, dried to a substantially dry state; eluted from the biological sample dried on the substrate by rehydrating the substrate in an elution buffer.

    Abstract translation: 提供了一种在干态下生物样品储存和生物分子洗脱的固体底物。 干燥的固体底物涂覆有糖，例如单糖，寡糖，多糖或其组合，并且底物由一种或多种在基本干燥状态下浸渍的蛋白质变性剂组成。 还提供了用于从生物样品中洗脱生物分子的方法。 本文公开的组合物提供来自样品的生物分子（例如核酸）的增强的洗脱和回收。 将样品置于基材上，干燥至基本干燥状态; 通过在洗脱缓冲液中再水化底物，从在底物上干燥的生物样品中洗脱。

    SUBSTRATES AND ASSOCIATED METHODS FOR ELUTION OF NUCLEIC ACIDS
    7.
    发明申请
    SUBSTRATES AND ASSOCIATED METHODS FOR ELUTION OF NUCLEIC ACIDS 有权
    用于提取核酸的基质和相关方法

    公开(公告)号：US20150119566A1

    公开(公告)日：2015-04-30

    申请号：US14068633

    申请日：2013-10-31

    Applicant: General Electric Company

    Inventor： Bing Li ,  Gregory Andrew Grossmann ,  Erik Leeming Kvam ,  Brian Christopher Bales ,  Jason Louis Davis

    IPC: C12N15/10 ,  B01J20/26 ,  B01J20/22

    CPC classification number: C12N15/1006 ,  B01J20/22 ,  B01J20/261 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3255 ,  B01J20/3274 ,  C12N15/1017

    Abstract: A solid substrate for biological sample storage under dry-state and elution of biomolecules is provided. The dry, solid substrate is coated with saccharides, such as monosaccharides, oligosaccharides, polysaccharides or combinations thereof, and the substrate is comprised of one or more protein denaturing agents impregnated therein under a substantially dry state. A method for elution of biomolecules from biological samples is also provided. The compositions disclosed herein provide for enhanced elution and recovery of biomolecules, such as nucleic acids, from the sample. The sample is disposed on a substrate, dried to a substantially dry state; eluted from the biological sample dried on the substrate by rehydrating the substrate in an elution buffer.

    Abstract translation: 提供了一种在干态下生物样品储存和生物分子洗脱的固体底物。 干燥的固体底物涂覆有糖，例如单糖，寡糖，多糖或其组合，并且底物由一种或多种在基本干燥状态下浸渍的蛋白质变性剂组成。 还提供了用于从生物样品中洗脱生物分子的方法。 本文公开的组合物提供来自样品的生物分子（例如核酸）的增强的洗脱和回收。 将样品置于基材上，干燥至基本干燥状态; 通过在洗脱缓冲液中再水化底物，从在底物上干燥的生物样品中洗脱。

    POROUS MEMBRANES WITH A POLYMER GRAFTING, METHODS AND USES THEREOF
    10.
    发明申请
    POROUS MEMBRANES WITH A POLYMER GRAFTING, METHODS AND USES THEREOF 审中-公开
    多孔膜与聚合物接枝，其方法和用途

    公开(公告)号：US20160146802A1

    公开(公告)日：2016-05-26

    申请号：US14548383

    申请日：2014-11-20

    Applicant: General Electric Company

    Inventor： Bing Li ,  Brian Christopher Bales ,  David Roger Moore ,  Jason Michael Nichols ,  Cathryn Ellen Olsen ,  William Christopher Alberts ,  Frank John Mondello

    IPC: G01N33/543 ,  G01N33/548 ,  G01N33/558

    CPC classification number: G01N33/54386 ,  G01N33/54353 ,  G01N33/548 ,  G01N33/558

    Abstract: A device comprising a modified porous membrane is provided. The modified porous membrane comprises a polymer coating grafted to a porous membrane. The device is used for analyte detection from a biological sample using an immunoassay. The device comprises a sample application zone at one end of the device for applying a biological sample comprising a target analyte; and a detection zone present at another end of the device, downstream of the sample application zone for detecting the target analyte, wherein the detection zone comprises one or more first biomolecules immobilized on a modified porous membrane having a structure of Formula (I).

    Abstract translation: 提供了包含改性多孔膜的装置。 改性多孔膜包括接枝到多孔膜上的聚合物涂层。 该装置用于使用免疫测定从生物样品进行分析物检测。 该装置包括用于施加包含目标分析物的生物样品的装置的一端处的样品施加区域; 以及位于所述装置的另一端的检测区，其位于所述样品施加区的下游，用于检测所述目标分析物，其中所述检测区包含固定在具有式（I）的结构的改性多孔膜上的一个或多个第一生物分子。

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