公开(公告)号：US09862934B2

公开(公告)日：2018-01-09

申请号：US14670459

申请日：2015-03-27

Applicant: GENETHON

Inventor： Otto-Wilhelm Merten ,  Martin Marek ,  Monique Van Oers

IPC: C12N15/866 ,  C12N15/86 ,  C12N7/00

CPC classification number: C12N7/00 ,  C12N15/86 ,  C12N2710/14143 ,  C12N2710/14152 ,  C12N2750/14143 ,  C12N2800/50

Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with a reduced number of or without contaminating baculoviral virions.

公开(公告)号：US12098355B2

公开(公告)日：2024-09-24

申请号：US16627013

申请日：2018-06-29

Applicant: UNIVERSITE DE PARIS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  GENETHON

Inventor： Florence Gazeau ,  Amanda Karine Andriola Silva ,  Otto-Wilhelm Merten ,  Claire Wilhelm ,  Max Piffoux

IPC: C12M3/06 ,  C12M1/00 ,  C12M1/12

CPC classification number: C12M27/14 ,  C12M25/16 ,  C12M29/04

Abstract: A fluidic system for producing extracellular vesicles from producer cells, including at least one container, a liquid medium contained by the container and producer cells, characterised in that it also includes microcarriers suspended in the liquid medium, the majority of producer cells being adherent to the surface of the microcarriers, and a liquid medium agitator, the agitator and the dimensions of the container being adapted to control a turbulent flow of the liquid medium in the container.

公开(公告)号：US11236307B2

公开(公告)日：2022-02-01

申请号：US16551787

申请日：2019-08-27

Applicant: GENETHON

Inventor： Otto-Wilhelm Merten ,  Martin Marek ,  Monique Van Oers

IPC: C12N7/00 ,  C12N15/86

Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with a reduced number of or without contaminating baculoviral virions.

公开(公告)号：US10767192B2

公开(公告)日：2020-09-08

申请号：US16029870

申请日：2018-07-09

Applicant: GENETHON

Inventor： Lionel Galibert ,  Otto-Wilhelm Merten ,  Aurelien Jacob

IPC: C12N15/86 ,  C12N7/00

Abstract: The invention relates to a recombinant baculoviral genome useful for the production of viral vectors for gene therapy, allowing said production from a single infection.

公开(公告)号：US11376321B2

公开(公告)日：2022-07-05

申请号：US16490181

申请日：2018-03-01

Applicant: GENETHON ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  SORBONNE UNIVERSITÉ ,  ASSOCIATION INSTITUT DE MYOLOGIE

Inventor： Bérangére Bertin ,  Carole Masurier ,  Otto-Wilhelm Merten ,  Federico Mingozzi

IPC: A61K39/235 ,  A61M1/36 ,  C07K16/06 ,  C07K16/08 ,  C12N7/00

Abstract: The present invention relates to a method for removing undesired anti-AAV antibodies from a blood-derived composition.

公开(公告)号：US10465169B2

公开(公告)日：2019-11-05

申请号：US15105880

申请日：2014-12-17

Applicant: GENETHON

Inventor： Driss Boudeffa ,  Otto-Wilhelm Merten ,  David Fenard

IPC: C07K16/24 ,  A61K39/395 ,  C07K16/00 ,  C12N15/113 ,  A61K39/00 ,  C12N7/00 ,  C12N15/86

Abstract: The invention relates to a process for purifying enveloped viruses. The process of the invention is useful for recovering at a large scale enveloped viruses under conditions complying with good manufacturing practices and allowing viruses of a clinical grade to be obtained.

公开(公告)号：US10428315B2

公开(公告)日：2019-10-01

申请号：US15841359

申请日：2017-12-14

Applicant: GENETHON

Inventor： Otto-Wilhelm Merten ,  Martin Marek ,  Monique Van Oers

IPC: C12N7/00 ,  C12N15/86 ,  C12N15/88

Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with a reduced number of or without contaminating baculoviral virions.