公开(公告)号：US11155832B2

公开(公告)日：2021-10-26

申请号：US16338075

申请日：2017-09-29

Applicant: GenVec, Inc.

Inventor： Sebastien M. Maloveste ,  Damodar Ettyreddy ,  Douglas E. Brough

IPC: C12N15/00 ,  A61K39/23 ,  C12N15/86 ,  C07K14/005

Abstract: The invention provides adenoviral vectors and compositions for the highly efficient transduction of T cells.

公开(公告)号：US10787682B2

公开(公告)日：2020-09-29

申请号：US16043501

申请日：2018-07-24

Applicant: GenVec, Inc.

Inventor： Douglas E. Brough ,  Jason G. D. Gall ,  Duncan McVey

IPC: C12N15/86 ,  C07K14/005 ,  C12N7/00 ,  A61K48/00

Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

公开(公告)号：US10125174B2

公开(公告)日：2018-11-13

申请号：US15618740

申请日：2017-06-09

Applicant: GenVec, Inc.

Inventor： Lisa Wei ,  Douglas E. Brough ,  Christopher Lazarski

IPC: C07K14/005 ,  A61K39/12 ,  C12N7/00 ,  A61K39/245 ,  A61K39/00

Abstract: Herpes Simplex Virus (HSV) antigens that elicit an HSV-specific immune response and can be used to treat or prevent HSV infection are provided. Nucleic acid sequences, polypeptides, vectors, and compositions, as well as methods to induce an immune response against HSV, treat or prevent HSV disease, induce a T cell response against HSV, and induce an antibody response against HSV also are provided.

公开(公告)号：US20180223290A1

公开(公告)日：2018-08-09

申请号：US15698259

申请日：2017-09-07

Applicant: GenVec, Inc.

Inventor： Jason G.D. Gall ,  Douglas E. Brough ,  C. Richter King

IPC: C12N15/63 ,  C12N7/00 ,  C12N15/86

CPC classification number: C12N15/635 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/10352 ,  C12N2830/006

Abstract: The invention provides a method of propagating an adenoviral vector. The method comprises (a) providing a cell comprising a cellular genome comprising a nucleic acid sequence encoding a tetracycline operon repressor protein (tetR), and (b) contacting the cell with an adenoviral vector comprising a heterologous nucleic acid sequence encoding a toxic protein. The heterologous nucleic acid sequence is operably linked to a promoter and one or more tetracycline operon operator sequences (tetO), and expression of the heterologous nucleic acid sequence is inhibited in the presence of tetR, such that the adenoviral vector is propagated. The invention also provides a system comprising the aforementioned cell and adenoviral vector.

公开(公告)号：US20180066281A1

公开(公告)日：2018-03-08

申请号：US15650289

申请日：2017-07-14

Applicant: GenVec, Inc.

Inventor： Jason G.D. Gall ,  Duncan McVey ,  Douglas E. Brough

IPC: C12N15/86 ,  A61K39/155 ,  C07K14/005 ,  C12N7/00

CPC classification number: C12N15/86 ,  A61K39/155 ,  A61K48/00 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10043 ,  C12N2710/10322 ,  C12N2710/10333 ,  C12N2710/10343

Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

公开(公告)号：US20170275339A1

公开(公告)日：2017-09-28

申请号：US15618740

申请日：2017-06-09

Applicant: GenVec, Inc.

Inventor： Lisa Wei ,  Douglas E. Brough ,  Christopher Lazarski

IPC: C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  C12N7/00 ,  A61K39/00

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/53 ,  A61K2039/545 ,  C12N7/00 ,  C12N2710/10043 ,  C12N2710/16622 ,  C12N2710/16634 ,  C12N2799/022 ,  C12N2800/22

Abstract: Herpes Simplex Virus (HSV) antigens that elicit an HSV-specific immune response and can be used to treat or prevent HSV infection are provided. Nucleic acid sequences, polypeptides, vectors, and compositions, as well as methods to induce an immune response against HSV, treat or prevent HSV disease, induce a T cell response against HSV, and induce an antibody response against HSV also are provided.

公开(公告)号：US09388429B2

公开(公告)日：2016-07-12

申请号：US14288493

申请日：2014-05-28

Applicant: GenVec, Inc.

Inventor： Jason G. D. Gall ,  Douglas E. Brough ,  C. Richter King

IPC: C12N7/01 ,  C12N15/861 ,  C12N15/86 ,  C12N7/00 ,  C12N15/63

CPC classification number: C12N15/635 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/10352 ,  C12N2830/006

Abstract: The invention provides a method of propagating an adenoviral vector. The method comprises (a) providing a cell comprising a cellular genome comprising a nucleic acid sequence encoding a tetracycline operon repressor protein (tetR), and (b) contacting the cell with an adenoviral vector comprising a heterologous nucleic acid sequence encoding a toxic protein. The heterologous nucleic acid sequence is operably linked to a promoter and one or more tetracycline operon operator sequences (tetO), and expression of the heterologous nucleic acid sequence is inhibited in the presence of tetR, such that the adenoviral vector is propagated. The invention also provides a system comprising the aforementioned cell and adenoviral vector.

Abstract translation: 本发明提供了一种繁殖腺病毒载体的方法。 该方法包括（a）提供包含细胞基因组的细胞，所述细胞基因组包含编码四环素操纵子阻遏蛋白（tetR）的核酸序列，和（b）使细胞与包含编码毒性蛋白质的异源核酸序列的腺病毒载体接触。 异源核酸序列可操作地连接到启动子和一个或多个四环素操纵子操纵子序列（tetO），并且异源核酸序列的表达在tetR存在下被抑制，使得腺病毒载体被繁殖。 本发明还提供了包含上述细胞和腺病毒载体的系统。

公开(公告)号：US20190316152A1

公开(公告)日：2019-10-17

申请号：US16282924

申请日：2019-02-22

Applicant: GenVec, Inc.

Inventor： Jason G.D. Gall ,  Duncan McVey ,  Douglas E. Brough

IPC: C12N15/86 ,  A61K39/155 ,  C07K14/005 ,  C12N7/00

Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

公开(公告)号：US20190269794A1

公开(公告)日：2019-09-05

申请号：US16352459

申请日：2019-03-13

Applicant: GenVec, Inc.

Inventor： Duncan McVey ,  Douglas E. Brough ,  Jason G.D. Gall

IPC: A61K48/00 ,  A61K39/155 ,  C12N7/00 ,  C12N15/86 ,  C07K14/005

Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

公开(公告)号：US20190247483A1

公开(公告)日：2019-08-15

申请号：US16393035

申请日：2019-04-24

Applicant: GenVec, Inc.

Inventor： Ping Chen ,  Duncan McVey ,  Douglas E. Brough ,  Joseph Bruder

IPC: A61K39/015

CPC classification number: A61K39/015 ,  A61K2039/5256 ,  A61K2039/53 ,  Y02A50/412

Abstract: The invention is directed to a composition comprising one or more polypeptides or one or more nucleic acid sequences that can induce a protective immune response against Plasmodium species that infect humans. The invention also is directed to a method of using such compositions to induce a protective immune response against a Plasmodium parasite in a mammal.