公开(公告)号：US20160264953A1

公开(公告)日：2016-09-15

申请号：US15030555

申请日：2014-10-22

Applicant: GENZYME CORPORATION

Inventor： Karen Lee ,  Christopher Hwang ,  Christine Demaria

IPC: C12N9/40 ,  A61K38/47 ,  A61K9/00 ,  C12P21/00 ,  A61K9/19 ,  C12N5/00 ,  A61K45/06

CPC classification number: C12N9/2465 ,  A61K9/0019 ,  A61K9/19 ,  A61K38/00 ,  A61K38/47 ,  A61K45/06 ,  C07K14/70592 ,  C12N5/00 ,  C12N2510/00 ,  C12P21/005 ,  C12Y302/01022

Abstract: Provided herein are recombinant glycoproteins (e.g., recombinant human α-galactosidase-A proteins) with an altered (e.g., improved) glycosylation profile, and pharmaceutical compositions and kits including one or more of these proteins. Also provided are methods of generating a mammalian cell useful for recombinant expression of a glycoprotein (e.g., recombinant human α-galactosidase-A), methods of producing recombinant glycoproteins, and methods of treatment that include administering to a subject at least one of the recombinant glycoproteins (e.g., recombinant human α-galactosidase-A protein).

Abstract translation: 本文提供具有改变（例如，改进的）糖基化谱的重组糖蛋白（例如，重组人α-半乳糖苷酶-A蛋白），以及包括这些蛋白质中的一种或多种的药物组合物和试剂盒。 还提供了产生可用于糖蛋白重组表达的哺乳动物细胞的方法（例如，重组人α-半乳糖苷酶-A），产生重组糖蛋白的方法和治疗方法，其包括向受试者施用至少一种重组 糖蛋白（例如，重组人α-半乳糖苷酶-A蛋白）。

公开(公告)号：US20220064617A1

公开(公告)日：2022-03-03

申请号：US17482193

申请日：2021-09-22

Applicant: Genzyme Corporation

Inventor： Karen Lee ,  Christopher Hwang ,  Christine DeMaria

IPC: C12N9/40 ,  C12P21/00 ,  C07K14/705 ,  A61K9/00 ,  A61K9/19 ,  A61K38/47 ,  A61K45/06 ,  C12N5/00

Abstract: Provided herein are recombinant glycoproteins (e.g., recombinant human α-galactosidase-A proteins) with an altered (e.g., improved) glycosylation profile, and pharmaceutical compositions and kits including one or more of these proteins. Also provided are methods of generating a mammalian cell useful for recombinant expression of a glycoprotein (e.g., recombinant human α-galactosidase-A), methods of producing recombinant glycoproteins, and methods of treatment that include administering to a subject at least one of the recombinant glycoproteins (e.g., recombinant human α-galactosidase-A protein).

公开(公告)号：US11208644B2

公开(公告)日：2021-12-28

申请号：US15030555

申请日：2014-10-22

Applicant: Genzyme Corporation

Inventor： Karen Lee ,  Christopher Hwang ,  Christine DeMaria

IPC: C12N9/40 ,  A61K38/47 ,  A61K38/00 ,  C12P21/00 ,  C07K14/705 ,  A61K9/00 ,  A61K9/19 ,  A61K45/06 ,  C12N5/00

Abstract: Provided herein are recombinant glycoproteins (e.g., recombinant human α-galactosidase-A proteins) with an altered (e.g., improved) glycosylation profile, and pharmaceutical compositions and kits including one or more of these proteins. Also provided are methods of generating a mammalian cell useful for recombinant expression of a glycoprotein (e.g., recombinant human α-galactosidase-A), methods of producing recombinant glycoproteins, and methods of treatment that include administering to a subject at least one of the recombinant glycoproteins (e.g., recombinant human α-galactosidase-A protein).