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    RECOMBINANT GLYCOPROTEINS AND USES THEREOF
    2.
    发明申请
    RECOMBINANT GLYCOPROTEINS AND USES THEREOF 审中-公开
    重组糖蛋白及其用途

    公开(公告)号：US20160264953A1

    公开(公告)日：2016-09-15

    申请号：US15030555

    申请日：2014-10-22

    Applicant: GENZYME CORPORATION

    Inventor： Karen Lee ,  Christopher Hwang ,  Christine Demaria

    IPC: C12N9/40 ,  A61K38/47 ,  A61K9/00 ,  C12P21/00 ,  A61K9/19 ,  C12N5/00 ,  A61K45/06

    CPC classification number: C12N9/2465 ,  A61K9/0019 ,  A61K9/19 ,  A61K38/00 ,  A61K38/47 ,  A61K45/06 ,  C07K14/70592 ,  C12N5/00 ,  C12N2510/00 ,  C12P21/005 ,  C12Y302/01022

    Abstract: Provided herein are recombinant glycoproteins (e.g., recombinant human α-galactosidase-A proteins) with an altered (e.g., improved) glycosylation profile, and pharmaceutical compositions and kits including one or more of these proteins. Also provided are methods of generating a mammalian cell useful for recombinant expression of a glycoprotein (e.g., recombinant human α-galactosidase-A), methods of producing recombinant glycoproteins, and methods of treatment that include administering to a subject at least one of the recombinant glycoproteins (e.g., recombinant human α-galactosidase-A protein).

    Abstract translation: 本文提供具有改变（例如，改进的）糖基化谱的重组糖蛋白（例如，重组人α-半乳糖苷酶-A蛋白），以及包括这些蛋白质中的一种或多种的药物组合物和试剂盒。 还提供了产生可用于糖蛋白重组表达的哺乳动物细胞的方法（例如，重组人α-半乳糖苷酶-A），产生重组糖蛋白的方法和治疗方法，其包括向受试者施用至少一种重组 糖蛋白（例如，重组人α-半乳糖苷酶-A蛋白）。

    Recombinant Glycoproteins and Uses Thereof
    4.
    发明申请
    Recombinant Glycoproteins and Uses Thereof 有权

    公开(公告)号：US20220064617A1

    公开(公告)日：2022-03-03

    申请号：US17482193

    申请日：2021-09-22

    Applicant: Genzyme Corporation

    Inventor： Karen Lee ,  Christopher Hwang ,  Christine DeMaria

    IPC: C12N9/40 ,  C12P21/00 ,  C07K14/705 ,  A61K9/00 ,  A61K9/19 ,  A61K38/47 ,  A61K45/06 ,  C12N5/00

    Abstract: Provided herein are recombinant glycoproteins (e.g., recombinant human α-galactosidase-A proteins) with an altered (e.g., improved) glycosylation profile, and pharmaceutical compositions and kits including one or more of these proteins. Also provided are methods of generating a mammalian cell useful for recombinant expression of a glycoprotein (e.g., recombinant human α-galactosidase-A), methods of producing recombinant glycoproteins, and methods of treatment that include administering to a subject at least one of the recombinant glycoproteins (e.g., recombinant human α-galactosidase-A protein).

    METHODS OF CULTURING A MAMMALIAN CELL
    6.
    发明申请
    METHODS OF CULTURING A MAMMALIAN CELL 审中-公开
    培养MAMMALIAN细胞的方法

    公开(公告)号：US20160177361A1

    公开(公告)日：2016-06-23

    申请号：US14976486

    申请日：2015-12-21

    Applicant: Genzyme Corporation

    Inventor： Christopher Hwang ,  Timothy Johnson ,  Jason Walther ,  Cheng Cheng ,  Jonathan Wang ,  Neha Shah ,  Seul-A Bae

    IPC: C12P21/00 ,  C07K16/00

    CPC classification number: C12P21/00 ,  C07K16/00 ,  C07K2317/14 ,  C12N5/0043 ,  C12N5/005 ,  C12N2500/50 ,  C12N2510/02

    Abstract: Provided herein are methods of culturing a mammalian cell in a liquid medium including poloxamer-188 at a concentration of 1.8 g/L or at a greater concentration than 1.8 g/L more or a liquid medium that includes a poloxamer-188 concentration that is selected based on one or more factors selected from the group of: pore size, pore type, gas flow rate, viable cell density in the medium, and markers related to cell stress.

    Abstract translation: 本文提供了在液体培养基中培养哺乳动物细胞的方法，所述液体培养基包括浓度为1.8g / L或浓度高于1.8g / L的泊洛沙姆-188或包含选择的泊洛沙姆188浓度的液体培养基 基于选自以下组中的一种或多种因素：孔径，孔型，气体流速，培养基中的活细胞密度和与细胞应激相关的标记。

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