公开(公告)号：US10717084B2

公开(公告)日：2020-07-21

申请号：US15774684

申请日：2016-11-09

Applicant: GEORGIA TECH RESEARCH CORPORATION

Inventor： Todd Sulchek ,  Alexander Alexeev ,  Gonghao Wang

IPC: G01N33/48 ,  G01N33/00 ,  G01N15/06 ,  B01L3/00 ,  G01N15/02 ,  G01N33/50 ,  G01N15/00 ,  G01N33/49

Abstract: Microfluidic devices for cell sorting or cell fractionation are disclosed. A microfluidic device can comprise one or more inlets, a first wall and a second wall, and two or more outlets. The first and second walls can be substantially planar to each other and the first wall having can have a plurality of ridges protruding from the first wall and defining a compression gap between the ridge and a surface of the second wall. The microfluidic device can also be a cell sorting device for sorting a plurality of cells based on one or more biophysical cellular properties including size, elasticity, viscosity, and/or viscoelasticity wherein the cells are subjected to one or more compressions due to the compression gap. Also disclosed are methods for cell sorting based on a variety of biophysical cellular properties.

公开(公告)号：US20200330990A1

公开(公告)日：2020-10-22

申请号：US16918349

申请日：2020-07-01

Applicant: GEORGIA TECH RESEARCH CORPORATION

Inventor： Todd Sulchek ,  Alexander Alexeev ,  Gonghao Wang

IPC: B01L3/00 ,  G01N15/02 ,  G01N33/50 ,  G01N33/48

Abstract: Microfluidic devices for cell sorting or cell fractionation are disclosed. A microfluidic device can comprise one or more inlets, a first wall and a second wall, and two or more outlets. The first and second walls can be substantially planar to each other and the first wall having can have a plurality of ridges protruding from the first wall and defining a compression gap between the ridge and a surface of the second wall. The microfluidic device can also be a cell sorting device for sorting a plurality of cells based on one or more biophysical cellular properties including size, elasticity, viscosity, and/or viscoelasticity wherein the cells are subjected to one or more compressions due to the compression gap. Also disclosed are methods for cell sorting based on a variety of biophysical cellular properties.

公开(公告)号：US11925934B2

公开(公告)日：2024-03-12

申请号：US16918349

申请日：2020-07-01

Applicant: GEORGIA TECH RESEARCH CORPORATION

Inventor： Todd Sulchek ,  Alexander Alexeev ,  Gonghao Wang

IPC: B01L3/00 ,  G01N15/02 ,  G01N33/48 ,  G01N33/49 ,  G01N33/50

CPC classification number: B01L3/502761 ,  G01N15/0272 ,  G01N33/48 ,  G01N33/5005 ,  B01L3/502776 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/086 ,  G01N15/01 ,  G01N2015/0288 ,  G01N33/491

Abstract: Microfluidic devices for cell sorting or cell fractionation are disclosed. A microfluidic device can comprise one or more inlets, a first wall and a second wall, and two or more outlets. The first and second walls can be substantially planar to each other and the first wall having can have a plurality of ridges protruding from the first wall and defining a compression gap between the ridge and a surface of the second wall. The microfluidic device can also be a cell sorting device for sorting a plurality of cells based on one or more biophysical cellular properties including size, elasticity, viscosity, and/or viscoelasticity wherein the cells are subjected to one or more compressions due to the compression gap. Also disclosed are methods for cell sorting based on a variety of biophysical cellular properties.