公开(公告)号：US11078208B1

公开(公告)日：2021-08-03

申请号：US16805933

申请日：2020-03-02

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Elbert Chin ,  Jeromy J. Cottell ,  Ashley Anne Katana ,  Darryl Kato ,  John O. Link ,  Nathan Shapiro ,  Teresa Alejandra Trejo Martin ,  Zheng-Yu Yang

IPC: C07D405/14 ,  C07D487/08 ,  C07D491/04 ,  A61P31/18 ,  A61K45/06 ,  C07C275/16 ,  C07D401/12 ,  C07D471/08 ,  C07D487/10 ,  C07C243/28 ,  A61K31/52 ,  A61K31/55 ,  A61K31/553 ,  A61K31/685 ,  A61K31/688 ,  C07D403/12

Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.

公开(公告)号：US20170210756A1

公开(公告)日：2017-07-27

申请号：US15227527

申请日：2016-08-03

Applicant: Gilead Sciences, Inc.

Inventor： Amy Cagulada ,  Johann Chan ,  Lina Chan ,  Denise A. Colby ,  Kapil Kumar Karki ,  Darryl Kato ,  Katie Ann Keaton ,  Sudha Kondapally ,  Christopher Levins ,  Adam Littke ,  Ruben Martinez ,  Dominika Pcion ,  Troy Reynolds ,  Bruce Ross ,  Michael Sangi ,  Adam J. Schrier ,  Pamela Seng ,  Dustin Siegel ,  Nathan Shapiro ,  Donald Tang ,  James G. Taylor ,  Jonathan Tripp ,  Andrew W. Waltman ,  Lawrence Yu

IPC: C07D498/18 ,  C07C271/34 ,  C07C255/61 ,  C07C205/57 ,  C07C233/09 ,  C07C251/12 ,  C07D403/12 ,  C07D241/44

CPC classification number: C07D498/18 ,  C07C51/09 ,  C07C205/57 ,  C07C209/00 ,  C07C227/02 ,  C07C233/09 ,  C07C251/12 ,  C07C255/61 ,  C07C271/34 ,  C07C2601/02 ,  C07D241/44 ,  C07D403/12 ,  C07D453/02 ,  C07D498/16 ,  C07K5/0808

Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.

公开(公告)号：US12084455B2

公开(公告)日：2024-09-10

申请号：US17224557

申请日：2021-04-07

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Elbert Chin ,  Jeromy J. Cottell ,  Ashley Anne Katana ,  Darryl Kato ,  John O. Link ,  Nathan Shapiro ,  Teresa Alejandra Trejo Martin ,  Zheng-Yu Yang

IPC: C07D405/14 ,  A61K31/52 ,  A61K31/55 ,  A61K31/553 ,  A61K31/685 ,  A61K31/688 ,  A61K45/06 ,  A61P31/18 ,  C07C243/28 ,  C07C275/16 ,  C07D401/12 ,  C07D403/12 ,  C07D471/08 ,  C07D487/08 ,  C07D487/10 ,  C07D491/04

CPC classification number: C07D487/08 ,  A61K31/52 ,  A61K31/55 ,  A61K31/553 ,  A61K31/685 ,  A61K31/688 ,  A61K45/06 ,  A61P31/18 ,  C07C243/28 ,  C07C275/16 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14 ,  C07D471/08 ,  C07D487/10 ,  C07D491/04

Abstract: The invention provides a compound of Formula I:






or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.

公开(公告)号：US11052087B2

公开(公告)日：2021-07-06

申请号：US16525203

申请日：2019-07-29

Applicant: Gilead Sciences, Inc.

Inventor： Elbert Chin ,  Darryl Kato ,  John O. Link ,  Nathan Shapiro ,  Zheng-Yu Yang

IPC: A61K31/506 ,  A61K31/4995 ,  C07D487/08 ,  A61P31/18

Abstract: The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.

公开(公告)号：US20200030327A1

公开(公告)日：2020-01-30

申请号：US16525203

申请日：2019-07-29

Applicant: Gilead Sciences, Inc.

Inventor： Elbert Chin ,  Darryl Kato ,  John O. Link ,  Nathan Shapiro ,  Zheng-Yu Yang

IPC: A61K31/506 ,  C07D487/08 ,  A61K31/4995 ,  A61P31/18

Abstract: The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.

公开(公告)号：US10442804B2

公开(公告)日：2019-10-15

申请号：US15885390

申请日：2018-01-31

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Eda Canales ,  Kevin S. Currie ,  Darryl Kato ,  Jiayao Li ,  John O. Link ,  Samuel E. Metobo ,  Roland D. Saito ,  Scott D. Schroeder ,  Nathan Shapiro ,  Winston C. Tse ,  Qiaoyin Wu ,  Yunfeng Eric Hu

IPC: C07D471/14 ,  C07D491/22 ,  C07D498/14 ,  C07D519/00 ,  A61P31/20 ,  C07B59/00

Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.

公开(公告)号：US20180258097A1

公开(公告)日：2018-09-13

申请号：US15888749

申请日：2018-02-05

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Elbert Chin ,  Jeromy J. Cottell ,  Ashley Anne Katana ,  Darryl Kato ,  John O. Link ,  Nathan Shapiro ,  Teresa Alejandra Trejo Martin ,  Zheng-Yu Yang

IPC: C07D487/08 ,  A61K45/06 ,  A61K31/55 ,  A61K31/685 ,  A61K31/688 ,  A61P31/18 ,  A61K31/52 ,  A61K31/553

CPC classification number: C07D487/08 ,  A61K31/52 ,  A61K31/55 ,  A61K31/553 ,  A61K31/685 ,  A61K31/688 ,  A61K45/06 ,  A61P31/18 ,  C07C243/28 ,  C07C275/16 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14 ,  C07D471/08 ,  C07D487/10 ,  C07D491/04

Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.

公开(公告)号：US20180251460A1

公开(公告)日：2018-09-06

申请号：US15885390

申请日：2018-01-31

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Eda Canales ,  Kevin S. Currie ,  Darryl Kato ,  Jiayao Li ,  John O. Link ,  Samuel E. Metobo ,  Roland D. Saito ,  Scott D. Schroeder ,  Nathan Shapiro ,  Winston C. Tse ,  Qiaoyin Wu

IPC: C07D471/14 ,  C07D498/14 ,  C07D519/00 ,  C07D491/22 ,  C07B59/00 ,  A61P31/20

CPC classification number: C07D471/14 ,  A61P31/20 ,  C07B59/002 ,  C07B2200/05 ,  C07D491/22 ,  C07D498/14 ,  C07D519/00

Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.

公开(公告)号：US10030033B2

公开(公告)日：2018-07-24

申请号：US15227527

申请日：2016-08-03

Applicant: Gilead Sciences, Inc.

Inventor： Amy Cagulada ,  Johann Chan ,  Lina Chan ,  Denise A. Colby ,  Kapil Kumar Karki ,  Darryl Kato ,  Katie Ann Keaton ,  Sudha Kondappally ,  Chris Levins ,  Adam Littke ,  Ruben Martinez ,  Dominika Pcion ,  Troy Reynolds ,  Bruce Ross ,  Michael Sangi ,  Adam J. Schrier ,  Pamela Seng ,  Dustin Siegel ,  Nathan Shapiro ,  Donald Tang ,  James G. Taylor ,  Jonathan Tripp ,  Andrew W. Waltman ,  Lawrence Yu

IPC: C07D498/16 ,  C07D403/12 ,  C07D498/18 ,  C07C271/34 ,  C07D241/44 ,  C07C205/57 ,  C07C233/09 ,  C07C251/12 ,  C07C255/61

Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.

公开(公告)号：US10294234B2

公开(公告)日：2019-05-21

申请号：US15888749

申请日：2018-02-05

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Elbert Chin ,  Jeromy J. Cottell ,  Ashley Anne Katana ,  Darryl Kato ,  John O. Link ,  Nathan Shapiro ,  Teresa Alejandra Trejo Martin ,  Zheng-Yu Yang

IPC: C07D487/08 ,  A61K31/444 ,  A61K31/506 ,  A61P31/18 ,  C07D403/12 ,  C07D405/14 ,  C07C275/16 ,  C07D401/12 ,  C07D471/08 ,  C07D487/10 ,  C07D491/04 ,  C07C243/28 ,  A61K31/52 ,  A61K31/55 ,  A61K31/553 ,  A61K31/685 ,  A61K31/688 ,  A61K45/06

Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.