公开(公告)号：US20180318415A1

公开(公告)日：2018-11-08

申请号：US15781351

申请日：2016-12-06

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： David BURKHART ,  Jay T. Evans ,  Hardeep OBEROI ,  Yvonne M. YORGENSEN

IPC: A61K39/39 ,  A61K39/145

CPC classification number: A61K39/39 ,  A61K9/5123 ,  A61K9/5161 ,  A61K31/7008 ,  A61K31/722 ,  A61K39/145 ,  A61K45/06 ,  A61K2039/541 ,  A61K2039/55555 ,  A61K2039/55572 ,  C12N2760/16134 ,  A61K2300/00

Abstract: The invention relates to a composition comprising solid lipid nanoparticles (SLNs), wherein the SLNs comprise an aminoalkyl glucosaminide phosphate (AGP).

公开(公告)号：US20220144865A1

公开(公告)日：2022-05-12

申请号：US17582150

申请日：2022-01-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Helene G. BAZIN-LEE ,  Jay T. EVANS ,  David BURKHART ,  Michael COCHRAN ,  David A. JOHNSON

IPC: C07F9/6561

Abstract: This invention relates inter alia to novel imidazoquinoline derivatives and their use in therapy, particularly as vaccine adjuvants.

公开(公告)号：US20180036403A1

公开(公告)日：2018-02-08

申请号：US15556520

申请日：2016-03-09

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： David BURKHART ,  Michael COCHRAN ,  Christopher W CLUFF ,  Daniel LAROCQUE ,  Helene G BAZIN-LEE ,  Julien ST JEAN

IPC: A61K39/39 ,  A61K31/52

CPC classification number: A61K39/39 ,  A61K31/52 ,  A61K31/522 ,  A61K2039/555 ,  A61K2039/55511 ,  A61K2039/627

Abstract: The present invention relates to immunogenic compositions and methods for producing them, and in particular, immunogenic compositions comprising a protein antigen cross linked to an oxoadenine adjuvant.

公开(公告)号：US20220144833A1

公开(公告)日：2022-05-12

申请号：US17582176

申请日：2022-01-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Helene G. BAZIN-LEE ,  Jay T. EVANS ,  David BURKHART ,  Michael COCHRAN ,  David A. JOHNSON

IPC: C07D471/04

Abstract: This invention relates inter alia to novel imidazoquinoline derivatives and their use in therapy, particularly as vaccine adjuvants.

公开(公告)号：US20200345841A1

公开(公告)日：2020-11-05

申请号：US16848910

申请日：2020-04-15

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： David BURKHART ,  Michael COCHRAN ,  Christopher W. CLUFF ,  Daniel LAROCQUE ,  Helene G BAZIN-LEE ,  Julien ST JEAN

IPC: A61K39/39 ,  A61K31/522 ,  A61K31/52

Abstract: The present invention relates to immunogenic compositions and methods for producing them, and in particular, immunogenic compositions comprising a protein antigen cross linked to an oxoadenine adjuvant.

公开(公告)号：US20170071967A1

公开(公告)日：2017-03-16

申请号：US15125387

申请日：2015-03-12

Applicant: GlaxoSmithKline Biologicals, SA

Inventor： Nupur DUTTA ,  Hardeep OBEROI ,  David BURKHART ,  Jay T EVANS

IPC: A61K31/7028 ,  A61K47/22 ,  A61K9/127

CPC classification number: A61K31/7028 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/1277 ,  A61K31/7008 ,  A61K47/22

Abstract: A liposomal composition comprising a liposome and an aminoalkansulfonic buffer is described and claimed.

Abstract translation: 描述和要求保护包含脂质体和氨基烷烃磺酸缓冲液的脂质体组合物。