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公开(公告)号：US09694064B2
公开(公告)日：2017-07-04
申请号：US14649940
申请日：2013-12-03
CPC分类号： A61K39/08 , A61K39/39 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , C07K14/33 , C07K2319/40
摘要： The present invention relates to immunogenic compositions comprising a Clostridium difficile (C. difficile) polypeptide and an aluminum-free adjuvant.
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公开(公告)号：US11241495B2
公开(公告)日：2022-02-08
申请号：US16179476
申请日：2018-11-02
发明人： Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号： A61K39/00 , A61K39/385 , A61K39/095 , C07H3/00 , A61K39/102 , A61K39/116 , A61K39/05 , A61K39/08 , A61K39/09 , A61K39/02 , A61K39/29 , A61K39/145 , C12N7/00 , A61K39/12
摘要： The present application discloses an immunogenic composition comprising N. meningitidis capsular polysaccharides from at least one of serogroups A, C, W135 and Y conjugated to a carrier protein to produce a N. meningitidis capsular polysaccharide conjugate, wherein the average size of each N. meningitidis polysaccharide is above 50 kDa.
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公开(公告)号：US10245317B2
公开(公告)日：2019-04-02
申请号：US15265597
申请日：2016-09-14
发明人： Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号： A61K39/00 , A61K39/02 , C07H3/00 , C12N7/00 , A61K39/08 , A61K39/09 , A61K39/385 , A61K39/095 , A61K39/102 , A61K39/116 , A61K39/05 , A61K39/29 , A61K39/145 , A61K39/12
摘要： The present application discloses an immunogenic composition comprising at least 2 different N. meningitidis capsular saccharides, wherein one or more is/are selected from a first group consisting of MenA, MenC, MenY and MenW which is/are conjugated through a linker to a carrier protein(s), and one or more different saccharides is/are selected from a second group consisting of MenA, MenC, MenY and MenW which is/are directly conjugated to a carrier protein(s).
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公开(公告)号：US20180064806A1
公开(公告)日：2018-03-08
申请号：US15691440
申请日：2017-08-30
发明人： Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号： A61K39/385 , A61K39/00 , A61K39/05 , A61K39/08 , A61K39/09 , A61K39/095 , A61K39/02 , A61K39/102 , A61K39/116 , A61K39/145 , A61K39/29 , C07H3/00 , C12N7/00
CPC分类号： A61K39/385 , A61K39/0017 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/099 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/145 , A61K39/292 , A61K2039/545 , A61K2039/55 , A61K2039/575 , A61K2039/6037 , A61K2039/62 , A61K2039/627 , A61K2039/70 , C07H3/00 , C12N7/00 , C12N2730/10134 , C12N2760/16234 , C12N2760/16271 , C12N2770/32634 , Y02A50/466 , Y02A50/484
摘要： present application discloses an immunogenic composition comprising N. meningitidis capsular polysaccharides from at least one of serogroups A, C, W135 and Y conjugated to a carrier protein to produce a N. meningitidis capsular polysaccharide conjugate, wherein the average size of each N. meningitidis polysaccharide is above 50 kDa.
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公开(公告)号：US10166287B2
公开(公告)日：2019-01-01
申请号：US15691440
申请日：2017-08-30
发明人： Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号： A61K39/00 , A61K39/385 , A61K39/095 , A61K39/102 , A61K39/116 , C07H3/00 , A61K39/05 , A61K39/08 , A61K39/09 , A61K39/02 , A61K39/29 , A61K39/145 , C12N7/00 , A61K39/12
摘要： present application discloses an immunogenic composition comprising N. meningitidis capsular polysaccharides from at least one of serogroups A, C, W135 and Y conjugated to a carrier protein to produce a N. meningitidis capsular polysaccharide conjugate, wherein the average size of each N. meningitidis polysaccharide is above 50 kDa.
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公开(公告)号：US10130694B2
公开(公告)日：2018-11-20
申请号：US15606439
申请日：2017-05-26
摘要： The present invention relates to immunogenic compositions comprising a Clostridium difficile (C. difficile) polypeptide and an aluminum-free adjuvant.
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公开(公告)号：US20170065714A1
公开(公告)日：2017-03-09
申请号：US15265597
申请日：2016-09-14
发明人： Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号： A61K39/385 , A61K39/145 , C12N7/00 , A61K39/095
CPC分类号： A61K39/385 , A61K39/0017 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/099 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/145 , A61K39/292 , A61K2039/545 , A61K2039/55 , A61K2039/575 , A61K2039/6037 , A61K2039/62 , A61K2039/627 , A61K2039/70 , C07H3/00 , C12N7/00 , C12N2730/10134 , C12N2760/16234 , C12N2760/16271 , C12N2770/32634 , Y02A50/466 , Y02A50/484
摘要： The present application discloses an immunogenic composition comprising at least 2 different N. meningitidis capsular saccharides, wherein one or more is/are selected from a first group consisting of MenA, MenC, MenY and MenW which is/are conjugated through a linker to a carrier protein(s), and one or more different saccharides is/are selected from a second group consisting of MenA, MenC, MenY and MenW which is/are directly conjugated to a carrier protein(s).
摘要翻译： 本申请公开了一种免疫原性组合物，其包含至少2种不同的脑膜炎奈瑟氏球菌荚膜糖苷，其中一种或多种选自MenA，MenC，MenY和MenW组成的第一组，其通过接头与载体共轭 蛋白质和一种或多种不同的糖选自由与载体蛋白直接缀合的MenA，MenC，MenY和MenW组成的第二组。
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公开(公告)号：US20200000911A1
公开(公告)日：2020-01-02
申请号：US16268287
申请日：2019-02-05
发明人： Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号： A61K39/385 , A61K39/00 , A61K39/095 , C07H3/00 , A61K39/102 , A61K39/116 , A61K39/05 , A61K39/08 , A61K39/09 , A61K39/02 , A61K39/29 , A61K39/145 , C12N7/00
摘要： The present application discloses an immunogenic composition comprising at least 2 different N. meningitidis capsular saccharides, wherein one or more is/are selected from a first group consisting of MenA, MenC, MenY and MenW which is/are conjugated through a linker to a carrier protein(s), and one or more different saccharides is/are selected from a second group consisting of MenA, MenC, MenY and MenW which is/are directly conjugated to a carrier protein(s).
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公开(公告)号：US20190298822A1
公开(公告)日：2019-10-03
申请号：US16179476
申请日：2018-11-02
发明人： Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号： A61K39/385 , A61K39/05 , A61K39/08 , A61K39/09 , A61K39/02 , A61K39/29 , C12N7/00 , A61K39/00 , A61K39/095 , A61K39/102 , A61K39/145 , C07H3/00 , A61K39/116
摘要： present application discloses an immunogenic composition comprising N. meningitidis capsular polysaccharides from at least one of serogroups A, C, W135 and Y conjugated to a carrier protein to produce a N. meningitidis capsular polysaccharide conjugate, wherein the average size of each N. meningitidis polysaccharide is above 50 kDa.
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公开(公告)号：US09358279B2
公开(公告)日：2016-06-07
申请号：US14525883
申请日：2014-10-28
发明人： Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号： A61K39/385 , A61K39/102 , A61K39/095 , A61K39/116 , C07H3/00 , A61K39/05 , A61K39/08 , A61K39/09 , A61K39/02 , A61K39/29 , A61K39/00 , A61K39/12
CPC分类号： A61K39/385 , A61K39/0017 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/099 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/145 , A61K39/292 , A61K2039/545 , A61K2039/55 , A61K2039/575 , A61K2039/6037 , A61K2039/62 , A61K2039/627 , A61K2039/70 , C07H3/00 , C12N7/00 , C12N2730/10134 , C12N2760/16234 , C12N2760/16271 , C12N2770/32634 , Y02A50/466 , Y02A50/472 , Y02A50/484
摘要： The present application discloses an immunogenic composition comprising a Hib saccharide conjugate, at least one additional bacterial, for example N. meningitidis, saccharide conjugate(s), and a further antigen selected from the group consisting of whole cell pertussis and hepatitis B surface antigen, wherein the saccharide dose of the Hib saccharide conjugate is less than 5 μg.
摘要翻译： 本申请公开了一种免疫原性组合物，其包含Hib糖结合物，至少一种额外的细菌，例如脑膜炎奈瑟球菌，糖结合物和选自全细胞百日咳和乙型肝炎表面抗原的另外的抗原， 其中Hib糖共轭物的糖剂量小于5μg。
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