公开(公告)号：US20170226161A1

公开(公告)日：2017-08-10

申请号：US15319651

申请日：2015-07-16

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Matthew Bottomley ,  Vega Masignani

IPC: C07K14/22 ,  A61K39/095

CPC classification number: C07K14/22 ,  A61K39/095 ,  A61K2039/575 ,  C07K2319/33

Abstract: The inventors have identified residues within variant 2 and variant 3 of meningococcal fHbp which can be modified to enhance their properties.

公开(公告)号：US11066450B2

公开(公告)日：2021-07-20

申请号：US15319651

申请日：2015-07-16

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Matthew Bottomley ,  Vega Masignani

IPC: C07K14/22 ,  A61K39/095 ,  A61K39/00

Abstract: The inventors have identified residues within variant 2 and variant 3 of meningococcal fHbp which can be modified to enhance their properties.

公开(公告)号：US11021522B2

公开(公告)日：2021-06-01

申请号：US16458365

申请日：2019-07-01

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Matthew Bottomley ,  Enrico Malito ,  Manuele Martinelli ,  Maria Scarselli

IPC: A61P37/04 ,  C07K14/22 ,  A61K39/095 ,  A61K39/00

Abstract: Modified meningococcal fHbp polypeptides with increased stability.

公开(公告)号：US10392424B2

公开(公告)日：2019-08-27

申请号：US15120674

申请日：2015-02-27

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Matthew Bottomley ,  Enrico Malito ,  Manuele Martinelli ,  Maria Scarselli

IPC: A61K39/095 ,  C07K14/22 ,  A61K39/00

Abstract: Modified meningococcal fHbp polypeptides with increased stability.

公开(公告)号：US11939357B2

公开(公告)日：2024-03-26

申请号：US17346362

申请日：2021-06-14

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Matthew Bottomley ,  Vega Masignani

IPC: C07K14/22 ,  A61K39/00 ,  A61K39/095

CPC classification number: C07K14/22 ,  A61K39/095 ,  A61K2039/575 ,  C07K2319/33

Abstract: The inventors have identified residues within variant 2 and variant 3 of meningococcal fHpb which can be modified to enhance their properties.

公开(公告)号：US11932671B2

公开(公告)日：2024-03-19

申请号：US17245681

申请日：2021-04-30

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Matthew Bottomley ,  Enrico Malito ,  Manuele Martinelli ,  Maria Scarselli

IPC: A61P37/04 ,  A61K39/095 ,  C07K14/22 ,  A61K39/00

CPC classification number: C07K14/22 ,  A61K39/095 ,  A61K2039/523 ,  A61K2039/55511 ,  A61K2039/70

Abstract: Modified meningococcal fHbp polypeptides with increased stability.