公开(公告)号：US09694063B2

公开(公告)日：2017-07-04

申请号：US14363387

申请日：2012-12-07

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Maria Scarselli ,  Mariagrazia Pizza ,  Rosanna Leuzzi ,  Maria Arico ,  Manuele Martinelli ,  Gillian Douce

IPC: A61K39/08 ,  C07K14/33 ,  A61K39/00

CPC classification number: A61K39/08 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/70 ,  C07K14/33 ,  C07K2319/20

Abstract: The present invention relates to recombinant fragments of C. difficile TcdA and TcdB that may be used in the development of vaccines against C. difficile associated disease. More particularly it relates to combinations comprising a ToxB-GT antigen and a TcdA antigen or a ToxA-GT antigen and a TcdB antigen.

公开(公告)号：US11021522B2

公开(公告)日：2021-06-01

申请号：US16458365

申请日：2019-07-01

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Matthew Bottomley ,  Enrico Malito ,  Manuele Martinelli ,  Maria Scarselli

IPC: A61P37/04 ,  C07K14/22 ,  A61K39/095 ,  A61K39/00

Abstract: Modified meningococcal fHbp polypeptides with increased stability.

公开(公告)号：US10392424B2

公开(公告)日：2019-08-27

申请号：US15120674

申请日：2015-02-27

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Matthew Bottomley ,  Enrico Malito ,  Manuele Martinelli ,  Maria Scarselli

IPC: A61K39/095 ,  C07K14/22 ,  A61K39/00

Abstract: Modified meningococcal fHbp polypeptides with increased stability.

公开(公告)号：US11932671B2

公开(公告)日：2024-03-19

申请号：US17245681

申请日：2021-04-30

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Matthew Bottomley ,  Enrico Malito ,  Manuele Martinelli ,  Maria Scarselli

IPC: A61P37/04 ,  A61K39/095 ,  C07K14/22 ,  A61K39/00

CPC classification number: C07K14/22 ,  A61K39/095 ,  A61K2039/523 ,  A61K2039/55511 ,  A61K2039/70

Abstract: Modified meningococcal fHbp polypeptides with increased stability.

公开(公告)号：US09932374B2

公开(公告)日：2018-04-03

申请号：US14425037

申请日：2013-09-19

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Cesira Galeotti ,  Rosanna Leuzzi ,  Mariagrazia Pizza ,  Maria Scarselli ,  Meera Unnikrishnan ,  Manuele Martinelli

IPC: A61K39/08 ,  C07K14/33 ,  C07K16/12 ,  A61K39/00

CPC classification number: C07K14/33 ,  A61K39/08 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/70 ,  C07K16/1282

Abstract: The invention provides methods, proteins, nucleic acids and antibodies for preventing or treating a C. difficile infection in a mammal.