公开(公告)号：US20220054632A1

公开(公告)日：2022-02-24

申请号：US17299347

申请日：2019-12-11

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Rainer FOLLADOR ,  Stefan Jochen KEMMLER ,  Michael Thomas KOWARIK ,  Gerald Johann POSCH

IPC: A61K39/385 ,  C07K14/22 ,  C07K14/28 ,  C07K14/33 ,  C07K14/34 ,  C07K14/21 ,  C07K14/205 ,  C07K14/245 ,  C12N15/70

Abstract: Carrier proteins modified to incorporate one or more pilin glycotags and applications thereof for O-linked glycosylation are provided. In particular, a modified carrier protein comprising a carrier protein that comprises at least one GlycoTag, wherein the at least one GlycoTag is a Neisseria gonorrhoeae PglL GlycoTag (NgGlycoTag), Neisseria lactamica PglL GlycoTag (NlGlycoTag), or Neisseria shayeganii GlycoTag (NsGlycoTag), or combinations thereof is provided, together with nucleic acids and vectors encoding the modified carrier protein, host cells comprising these modofoed carrier proteins or nucleic acids encoding them, bioconjugates, methods of making bioconjugates and uses of the bioconjugates.

公开(公告)号：US20240100140A1

公开(公告)日：2024-03-28

申请号：US18131557

申请日：2023-04-06

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Amirreza FARIDMOAYER ,  Rainer FOLLADOR ,  Stefan Jochen KEMMLER ,  Michael Thomas KOWARIK ,  Gerd Martin LIPOWSKY ,  Gerald Johann POSCH ,  Fabio SERVENTI

IPC: A61K39/09 ,  C12P19/04 ,  C12P21/00

CPC classification number: A61K39/092 ,  C12P19/04 ,  C12P21/005

Abstract: The disclosure provides synthetic (e.g. recombinant) pneumococcal saccharide comprising one or more repeat unit(s) →4)-β-D-Glcp-(1→3)-[[α-L-Rhap-(1→2)]-[Gro-(2→P→3)]-β-D-Galp-(1→4)]-β-L-Rhap-(1→. Also provided are conjugates comprising a →4)-β-D-Glcp-(1→3)-[[α-L-Rhap-(1→2)]-[Gro-(2→P→3)]-β-D-Galp-(1→4)]-β-L-Rhap-(1→, immunogenic compositions, vaccines and their use in preventing or treating infection by Streptococcus pneumoniae.

公开(公告)号：US20230060184A1

公开(公告)日：2023-03-02

申请号：US17804679

申请日：2022-05-31

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Amirreza FARIDMOAYER ,  Rainer FOLLADOR ,  Stefan Jochen KEMMLER ,  Michael Thomas KOWARIK ,  Gerald Johann POSCH ,  Fabio SERVENTI

IPC: A61K39/09 ,  C08B37/00 ,  A61K39/102

Abstract: The disclosure provides synthetic (e.g. recombinant) pneumococcal saccharides comprising one or more repeat unit(s) →4)-β-D-Glcp-(1→4)-[Gro-(2→P→3)]-β-D-Galp-(1→4)-β-L-Rhap-(1→. Also provided are conjugates comprising a →4)-β-D-Glcp-(1→4)-[Gro-(2→P→3)]-β-D-Galp-(1→4)-β-L-Rhap-(1→, immunogenic compositions, vaccines and their use in preventing or treating infection by Streptococcus pneumoniae.

公开(公告)号：US20200179505A1

公开(公告)日：2020-06-11

申请号：US16620911

申请日：2018-07-17

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Amirreza FARIDMOAYER ,  Rainer FOLLADOR ,  Stefan Jochen KEMMLER ,  Michael Thomas KOWARIK ,  Gerd Martin LIPOWSKY ,  Gerald Johann POSCH ,  Fabio SERVENTI

IPC: A61K39/09 ,  C12P19/04 ,  C12P21/00

Abstract: The disclosure provides synthetic (e.g. recombinant) pneumococcal saccharide comprising one or more repeat unit(s)→4)-β-D-Glcp-(1→3)-[[α-L-Rhap-(1→2)]-[Gro-(2→P→3)]-β-D-Galp-(1→4)]-β-L-Rhap-(1→.Also provided are conjugates comprising a →4)-β-D-Glcp-(1→3)-[[α-L-Rhap-(1→2)]-[Gro-(2→P→3)]-β-D-Galp-(1→4)]-β-L-Rhap-(1→, immunogenic compositions, vaccines and their use in preventing or treating infection by Streptococcus pneumoniae.

公开(公告)号：US20230293657A1

公开(公告)日：2023-09-21

申请号：US18001525

申请日：2021-06-17

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Maria Paula CARRANZA SANDMEIER ,  Rainer FOLLADOR ,  Veronica Gambillara FONCK ,  Stefan Jochen KEMMLER ,  Patricia Martin KILLIAS ,  Michael Thomas KOWARIK ,  Gerd Martin LIPOWSKY ,  Gerald Johann POSCH ,  Fabio SERVENTI ,  Dominique Nicolas SIRENA

IPC: A61K39/108 ,  C07K14/26 ,  A61P31/04 ,  C12N9/10

CPC classification number: A61K39/0266 ,  C07K14/26 ,  A61P31/04 ,  C12N9/1081 ,  C12Y204/99019 ,  A61K2039/6068

Abstract: The present invention relates to the field of immunogenic compositions and vaccines, their manufacture, host cells which can be used in their manufacture and the use of such immunogenic compositions and vaccines in medicine. More particularly, it relates to Klebsiella pneumoniae O-antigens, conjugates comprising a K. pneumoniae O-antigen, host cells suitable for their production and immunogenic compositions or vaccines containing at least one Klebsiella pneumoniae O-antigen.

公开(公告)号：US20230226175A1

公开(公告)日：2023-07-20

申请号：US18001498

申请日：2021-06-17

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Stefan Jochen KEMMLER ,  Christian LIZAK ,  Gerald Johann POSCH ,  Julien Laurent QUEBATTE

IPC: A61K39/385 ,  A61K39/108 ,  C12N9/10

CPC classification number: A61K39/385 ,  A61K39/0266 ,  C12N9/1077 ,  C12Y204/02036

Abstract: The present invention relates to the field of modified proteins, immunogenic compositions and vaccines comprising the modified proteins, their manufacture and the use of such compositions in medicine. More particularly, it relates to a modified EPA (Exotoxin A of Pseudomonas aeruginosa) protein. The modified EPA can be used as a carrier protein for other antigens, particularly saccharide antigens or other antigens lacking T cell epitopes.