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公开(公告)号：US20230293657A1
公开(公告)日：2023-09-21
申请号：US18001525
申请日：2021-06-17
发明人： Maria Paula CARRANZA SANDMEIER , Rainer FOLLADOR , Veronica Gambillara FONCK , Stefan Jochen KEMMLER , Patricia Martin KILLIAS , Michael Thomas KOWARIK , Gerd Martin LIPOWSKY , Gerald Johann POSCH , Fabio SERVENTI , Dominique Nicolas SIRENA
IPC分类号： A61K39/108 , C07K14/26 , A61P31/04 , C12N9/10
CPC分类号： A61K39/0266 , C07K14/26 , A61P31/04 , C12N9/1081 , C12Y204/99019 , A61K2039/6068
摘要： The present invention relates to the field of immunogenic compositions and vaccines, their manufacture, host cells which can be used in their manufacture and the use of such immunogenic compositions and vaccines in medicine. More particularly, it relates to Klebsiella pneumoniae O-antigens, conjugates comprising a K. pneumoniae O-antigen, host cells suitable for their production and immunogenic compositions or vaccines containing at least one Klebsiella pneumoniae O-antigen.
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公开(公告)号：US20180002679A1
公开(公告)日：2018-01-04
申请号：US15540690
申请日：2015-12-24
发明人： Jurgen HAAS , Julian IHSSEN , Michael Thomas KOWARIK , Torsten Franz SCHWEDE , Linda Christiane THÖNY-MEYER
CPC分类号： C12N9/1081 , C12P21/005
摘要： Described herein are oligosaccharyl transferases for use in N-glycosylating proteins of interest in vitro and in host cells. Methods for using such oligosaccharyl transferases, nucleic acids encoding such oligosaccharyl transferases, and host cells comprising such oligosaccharyl transferases are also provided herein. Glycoconjugates generated by using such oligosaccharyl transferases are also provided herein.
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公开(公告)号：US20220054632A1
公开(公告)日：2022-02-24
申请号：US17299347
申请日：2019-12-11
IPC分类号： A61K39/385 , C07K14/22 , C07K14/28 , C07K14/33 , C07K14/34 , C07K14/21 , C07K14/205 , C07K14/245 , C12N15/70
摘要： Carrier proteins modified to incorporate one or more pilin glycotags and applications thereof for O-linked glycosylation are provided. In particular, a modified carrier protein comprising a carrier protein that comprises at least one GlycoTag, wherein the at least one GlycoTag is a Neisseria gonorrhoeae PglL GlycoTag (NgGlycoTag), Neisseria lactamica PglL GlycoTag (NlGlycoTag), or Neisseria shayeganii GlycoTag (NsGlycoTag), or combinations thereof is provided, together with nucleic acids and vectors encoding the modified carrier protein, host cells comprising these modofoed carrier proteins or nucleic acids encoding them, bioconjugates, methods of making bioconjugates and uses of the bioconjugates.
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公开(公告)号：US20200179505A1
公开(公告)日：2020-06-11
申请号：US16620911
申请日：2018-07-17
发明人： Amirreza FARIDMOAYER , Rainer FOLLADOR , Stefan Jochen KEMMLER , Michael Thomas KOWARIK , Gerd Martin LIPOWSKY , Gerald Johann POSCH , Fabio SERVENTI
摘要： The disclosure provides synthetic (e.g. recombinant) pneumococcal saccharide comprising one or more repeat unit(s)→4)-β-D-Glcp-(1→3)-[[α-L-Rhap-(1→2)]-[Gro-(2→P→3)]-β-D-Galp-(1→4)]-β-L-Rhap-(1→.Also provided are conjugates comprising a →4)-β-D-Glcp-(1→3)-[[α-L-Rhap-(1→2)]-[Gro-(2→P→3)]-β-D-Galp-(1→4)]-β-L-Rhap-(1→, immunogenic compositions, vaccines and their use in preventing or treating infection by Streptococcus pneumoniae.
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公开(公告)号：US20240100140A1
公开(公告)日：2024-03-28
申请号：US18131557
申请日：2023-04-06
发明人： Amirreza FARIDMOAYER , Rainer FOLLADOR , Stefan Jochen KEMMLER , Michael Thomas KOWARIK , Gerd Martin LIPOWSKY , Gerald Johann POSCH , Fabio SERVENTI
CPC分类号： A61K39/092 , C12P19/04 , C12P21/005
摘要： The disclosure provides synthetic (e.g. recombinant) pneumococcal saccharide comprising one or more repeat unit(s) →4)-β-D-Glcp-(1→3)-[[α-L-Rhap-(1→2)]-[Gro-(2→P→3)]-β-D-Galp-(1→4)]-β-L-Rhap-(1→. Also provided are conjugates comprising a →4)-β-D-Glcp-(1→3)-[[α-L-Rhap-(1→2)]-[Gro-(2→P→3)]-β-D-Galp-(1→4)]-β-L-Rhap-(1→, immunogenic compositions, vaccines and their use in preventing or treating infection by Streptococcus pneumoniae.
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公开(公告)号：US20240279686A1
公开(公告)日：2024-08-22
申请号：US18605166
申请日：2024-03-14
CPC分类号： C12N15/902 , C12N9/1048 , C12N9/1051 , C12N2800/24 , C12N2800/30
摘要： A process for engineering a host cell comprising the steps of a) integrating a first polynucleotide cassette including a first selection marker flanked by a first pair of recombination sites; b) removing the first selection marker by the action of a recombinase which recognises the first pair of recombination sites; c) integrating a second polynucleotide cassette including a second selection marker flanked by a second pair of recombination sites; and d) removing the second selection marker by the action of a recombinase which recognises the second pair of recombination sites. The first and second pairs of recombination sites have identical nucleic acid sequences within each pair, sharing 90-98% nucleic acid sequence identity. Also disclosed is a host cell genome polynucleotide comprising two recombinantly engineered regions, each adjacent to a single recombination site sharing 90-98% identity with each other and any additional recombination sites present in the host cell genome polynucleotide.
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公开(公告)号：US20230060184A1
公开(公告)日：2023-03-02
申请号：US17804679
申请日：2022-05-31
发明人： Amirreza FARIDMOAYER , Rainer FOLLADOR , Stefan Jochen KEMMLER , Michael Thomas KOWARIK , Gerald Johann POSCH , Fabio SERVENTI
IPC分类号： A61K39/09 , C08B37/00 , A61K39/102
摘要： The disclosure provides synthetic (e.g. recombinant) pneumococcal saccharides comprising one or more repeat unit(s) →4)-β-D-Glcp-(1→4)-[Gro-(2→P→3)]-β-D-Galp-(1→4)-β-L-Rhap-(1→. Also provided are conjugates comprising a →4)-β-D-Glcp-(1→4)-[Gro-(2→P→3)]-β-D-Galp-(1→4)-β-L-Rhap-(1→, immunogenic compositions, vaccines and their use in preventing or treating infection by Streptococcus pneumoniae.
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公开(公告)号：US20220090143A1
公开(公告)日：2022-03-24
申请号：US16635352
申请日：2018-08-07
摘要： The present invention discloses a process for engineering a host cell comprising the steps of; a) integrating a first polynucleotide cassette including a first selection marker flanked by a first pair of recombination sites; b) removing the first selection marker by the action of a recombinase which recognises the first pair of recombination sites; c) integrating a second polynucleotide cassette including a second selection marker flanked by a second pair of recombination sites; and d) removing the second selection marker by the action of a recombinase which recognises the second pair of recombination sites. Also disclosed is a host cell genome polynucleotide comprising a first recombinantly engineered region and a second recombinantly engineered region, wherein a first single recombination site is adjacent to the first recombinantly engineered region, and a second single recombination site is adjacent to the second recombinantly engineered region.
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