公开(公告)号：US10544192B2

公开(公告)日：2020-01-28

申请号：US15623723

申请日：2017-06-15

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Stefano Colloca ,  Alfredo Nicosia ,  Riccardo Cortese, Sr. ,  Virginia Ammendola ,  Maria Ambrosio

IPC: C07K14/005 ,  A61K39/12 ,  A61K39/235 ,  C12N7/00 ,  C12N15/86 ,  A61K39/00 ,  A61K48/00

Abstract: The present invention relates to novel adenovirus strains with an improved seroprevalence. In one aspect, the present invention relates to isolated polypeptides of adenoviral capsid proteins such as hexon, penton and fiber protein and fragments thereof and polynucleotides encoding the same. Also provided is a vector comprising the isolated polynucleotide according to the invention and adenoviruses comprising the isolated polynucleotides or polypeptides according to the invention and a pharmaceutical composition comprising said vector, adenovirus, polypeptide and/or polynucleotide. The invention also relates to the use of the isolated polypeptides, the isolated polypeptides, the vector, the adenoviruses and/or the pharmaceutical composition for the therapy or prophylaxis of a disease.

公开(公告)号：US20180057540A1

公开(公告)日：2018-03-01

申请号：US15623723

申请日：2017-06-15

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Stefano Colloca ,  Alfredo Nicosia ,  Riccardo Cortese, Sr. ,  Virginia Ammendola ,  Maria Ambrosio

IPC: C07K14/005 ,  C12N15/86 ,  A61K39/12 ,  A61K39/235 ,  C12N7/00 ,  A61K39/00 ,  A61K48/00

CPC classification number: C07K14/005 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/235 ,  A61K48/00 ,  A61K2039/525 ,  A61K2039/5256 ,  A61K2039/545 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10321 ,  C12N2710/10322 ,  C12N2710/10334 ,  C12N2710/10343 ,  C12N2710/16634 ,  C12N2740/16134 ,  C12N2770/24234

Abstract: The present invention relates to novel adenovirus strains with an improved seroprevalence. In one aspect, the present invention relates to isolated polypeptides of adenoviral capsid proteins such as hexon, penton and fiber protein and fragments thereof and polynucleotides encoding the same. Also provided is a vector comprising the isolated polynucleotide according to the invention and adenoviruses comprising the isolated polynucleotides or polypeptides according to the invention and a pharmaceutical composition comprising said vector, adenovirus, polypeptide and/or polynucleotide. The invention also relates to the use of the isolated polypeptides, the isolated polypeptides, the vector, the adenoviruses and/or the pharmaceutical composition for the therapy or prophylaxis of a disease.