公开(公告)号：US20210246468A1

公开(公告)日：2021-08-12

申请号：US16973630

申请日：2019-06-11

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Virginia AMMENDOLA ,  Stefania CAPONE ,  Stefano COLLOCA ,  Antonella FOLGORI ,  Rosella MERONE

IPC分类号： C12N15/86 ,  A61K39/21 ,  A61P37/04

摘要： The present invention relates to isolated polynucleotide and polypeptide sequences derived from novel chimpanzee adenovirus ChAd157, as well as to recombinant polynucleotides, vectors, adenoviruses, cells and compositions comprising said polynucleotide and polypeptide sequences.

公开(公告)号：US20210198321A1

公开(公告)日：2021-07-01

申请号：US16770963

申请日：2018-12-14

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Stefania CAPONE ,  Antonella FOLGORI ,  Armin LAHM ,  Benjamin WIZEL

IPC分类号： C07K14/005 ,  C12N7/00 ,  A61K39/245

摘要： The invention provides Epstein-Barr Virus antigen polynucleotides, polypeptides and vectors; as well as immunogenic compositions comprising the same. It includes the use of Epstein-Barr Virus antigen constructs to produce vaccines for treating and preventing Epstein-Barr Virus infections and Epstein-Barr Virus-associated diseases, such as multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus.

公开(公告)号：US20240076318A1

公开(公告)日：2024-03-07

申请号：US18358350

申请日：2023-07-25

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Stefania CAPONE ,  Antonella FOLGORI ,  Armin LAHM ,  Benjamin WIZEL

IPC分类号： C07K14/005 ,  A61K39/245 ,  C12N7/00

CPC分类号： C07K14/005 ,  A61K39/245 ,  C12N7/00 ,  A61K2039/70

摘要： The invention provides Epstein-Barr Virus antigen polynucleotides, polypeptides and vectors; as well as immunogenic compositions comprising the same. It includes the use of Epstein-Barr Virus antigen constructs to produce vaccines for treating and preventing Epstein-Barr Virus infections and Epstein-Barr Virus-associated diseases, such as multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus.

公开(公告)号：US20220275397A1

公开(公告)日：2022-09-01

申请号：US17742221

申请日：2022-05-11

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Virginia AMMENDOLA ,  Stefania CAPONE ,  Stefano COLLOCA ,  Antonella FOLGORI ,  Rossella MERONE

IPC分类号： C12N15/86 ,  A61K39/21 ,  C07K14/005 ,  A61K39/12 ,  A61P31/18 ,  A61P31/14

摘要： The present invention relates to isolated polynucleotide and polypeptide sequences derived from novel chimpanzee adenovirus ChAd157, as well as to recombinant polynucleotides, vectors, adenoviruses, cells and compositions comprising said polynucleotide and polypeptide sequences.

公开(公告)号：US20220062409A1

公开(公告)日：2022-03-03

申请号：US17413203

申请日：2019-12-13

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Stefania CAPONE ,  Nicolas Frederic DELAHAYE ,  Giulietta MARUGGI ,  Haifeng SONG

IPC分类号： A61K39/245 ,  A61K39/21 ,  A61K39/205 ,  A61P31/14 ,  A61P31/18 ,  A61P31/22

摘要： Simian adenoviral vectors and RNA molecules, each encoding an immunogen of interest, can be sequentially administered to provide potent and long-lasting immunity.