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公开(公告)号：US11059816B2
公开(公告)日：2021-07-13
申请号：US16468777
申请日：2017-12-11
发明人： Anthony William James Cooper , Nicole Cathleen Goodwin , Charlotte Mary Griffiths-Jones , Thomas Daniel Heightman , Jeffrey K. Kerns , Hendrika Maria Gerarda Willems , Hongxing Yan
IPC分类号： A61K31/553 , A61P9/04 , A61P11/00 , C07D498/04 , C07D419/12 , C07D249/04 , C07D401/12 , C07D419/14 , C07D513/04
摘要： The present invention relates to ether-linked triazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof:
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公开(公告)号：US20220089590A1
公开(公告)日：2022-03-24
申请号：US17350183
申请日：2021-06-17
发明人： Anthony William James Cooper , Nicole Cathleen Goodwin , Charlotte Mary Griffiths-Jones , Thomas Daniel Heightman , Jeffrey K. Kerns , Hendrika Maria Gerarda Willems , Hongxing Yan
IPC分类号： C07D419/12 , C07D249/04 , C07D401/12 , C07D419/14 , C07D498/04 , C07D513/04
摘要： The present invention relates to ether-linked triazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof:
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公开(公告)号：US10793559B2
公开(公告)日：2020-10-06
申请号：US16572917
申请日：2019-09-17
发明人： Niall Andrew Anderson , Nicholas Paul Barton , Sebastien Andre Campos , Edward Paul Cannons , Anthony William James Cooper , Kenneth David Down , Kevin James Doyle , Julie Nicole Hamblin , Graham George Adam Inglis , Armelle Le Gall , Vipulkumar Kantibhai Patel , Simon Peace , Andrew Sharpe , Gemma Victoria White
IPC分类号： C07D413/14 , C07D213/76 , A61P25/28 , A61P11/06 , A61P37/08 , A61P25/24 , A61P15/08
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
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公开(公告)号：US11078216B2
公开(公告)日：2021-08-03
申请号：US16467538
申请日：2017-12-11
发明人： James Francis Callahan , Vincent J. Colandrea , Anthony William James Cooper , Nicole Cathleen Goodwin , Chelsea Ariane Huff , Joel Karpiak , Jeffrey K. Kerns , Hong Nie
IPC分类号： A61K31/554 , A61K31/553 , A61P1/16 , A61P9/00 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/06 , A61P35/00 , C07D281/02 , C07D417/06 , C07D417/12 , C07D417/14 , C07D419/06 , C07D419/12 , C07D419/14 , C07D513/04 , C07D515/04 , C07D401/14
摘要： The present invention relates to bisaryl amide analogs, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to bisaryl heterocycles of Formula (I),
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公开(公告)号：US10457674B2
公开(公告)日：2019-10-29
申请号：US16073355
申请日：2017-02-10
发明人： Niall Andrew Anderson , Nicholas Paul Barton , Sebastien Andre Campos , Edward Paul Cannons , Anthony William James Cooper , Kenneth David Down , Kevin James Doyle , Julie Nicole Hamblin , Graham George Adam Inglis , Armelle Le Gall , Vipulkumar Kantibhai Patel , Simon Peace , Andrew Sharpe , Gemma Victoria White
IPC分类号： C07D413/14 , C07D213/76 , A61P25/28 , A61P11/06 , A61P37/08 , A61P25/24 , A61P15/08
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
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公开(公告)号：US12091409B2
公开(公告)日：2024-09-17
申请号：US17350183
申请日：2021-06-17
发明人： Anthony William James Cooper , Nicole Cathleen Goodwin , Charlotte Mary Griffiths-Jones , Thomas Daniel Heightman , Jeffrey K. Kerns , Hendrika Maria Gerarda Willems , Hongxing Yan
IPC分类号： C07D249/04 , A61K31/4192 , A61K31/4402 , A61K31/55 , A61K31/553 , A61K31/554 , A61P9/04 , A61P11/00 , C07D401/12 , C07D413/12 , C07D417/12 , C07D419/12 , C07D419/14 , C07D471/04 , C07D498/04 , C07D513/04
CPC分类号： C07D419/12 , C07D249/04 , C07D401/12 , C07D419/14 , C07D498/04 , C07D513/04
摘要： The present invention relates to ether-linked triazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof:
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