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    MIXTURES OF HMOs
    4.
    发明申请
    MIXTURES OF HMOs 审中-公开

    公开(公告)号：US20170312298A1

    公开(公告)日：2017-11-02

    申请号：US15521582

    申请日：2015-10-23

    Applicant: Glycom A/S

    Inventor： Elise CHAMPION ,  Bruce MCCONNELL ,  Gyula DEKANY

    IPC: A61K31/702 ,  C12P19/18 ,  A61K31/715 ,  C12P19/26 ,  A61K31/7016

    CPC classification number: A61K31/702 ,  A61K31/7016 ,  A61K31/715 ,  C12P19/18 ,  C12P19/26 ,  C12Y204/01065 ,  A61K2300/00

    Abstract: The invention relates to a mixture of human milk oligosaccharides that consists essentially of: a) a component A which is 3-FL or DFL, a component B which is LNT, LNnT, LNFP-I or 2′-FL, a component C, which is LNFP-II when component B is LNT, or LNFP-III when component B is LNnT, or LNDFH-I when component B is LNFP-I, or DFL when component B is 2′-FL, and a component D, which is lactose when component A is 3-FL, or 2′-FL when component A is DFL, with the proviso that if component B is 2′-FL, then component A is 3-FL; or consists essentially of: b) 3-FL, a component E which is LNT, LNnT or LNFP-I, and a component F, which is LNFP-II when component E is LNT, or LNFP-III when component E is LNnT, or LNDFH-I when component E is LNFP-I, and to processes for producing them and their uses.

    SYNTHESIS OF SIALYLATED/FUCOSYLATED HUMAN MILK OLIGOSACCHARIDES
    5.
    发明申请
    SYNTHESIS OF SIALYLATED/FUCOSYLATED HUMAN MILK OLIGOSACCHARIDES 有权
    异亮氨酸/ FOSOSLIL人乳酪寡糖的合成

    公开(公告)号：US20160075729A1

    公开(公告)日：2016-03-17

    申请号：US14783783

    申请日：2014-04-11

    Applicant: GLYCOM A/S

    Inventor： Pierre CHASSAGNE ,  Nikolay KHANZHIN ,  Markus HEDEROS ,  Elise CHAMPION ,  Martin MATWIEJUK ,  Gyula DEKANY

    IPC: C07H5/04

    CPC classification number: C07H5/04 ,  C07H1/00

    Abstract: An achemo-enzymatic synthesis of oligosaccharides of formula 1 is presented wherein R is selected from —OH, —N3 and —OR6 wherein R6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, —(CH2)n—NH2 and —(CH2)n—N3 wherein integer n is to 10, preferably 2 or 3, R is selected from sialyl moiety, —SO3H and —CH(R)—COOH wherein R is selected from H, alkyl and benzyl, R2 is selected from H and fucosyl, R3 is selected from H and sialyl, R4 is selected from H and fucosyl, provided that at least one of R3 and R4 is H, and A is a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.

    Abstract translation: 其中R选自-OH，-N 3和-OR 6，其中R 6选自任选被一个或多个甲基取代的烯丙基，炔丙基任选被一个或多个甲基， 三甲基甲硅烷基 - 乙基， - （CH 2）n -NH 2和 - （CH 2）n -N 3其中整数n为10，优选2或3，R选自唾液酰基部分，-SO 3 H和-CH（R）-COOH，其中R 选自H，烷基和苄基，R2选自H和岩藻糖基，R3选自H和唾液烷基，R4选自H和岩藻糖基，条件是R3和R4中至少一个为H，A为二价 碳水化合物接头，对制药和食品工业具有重要的生物活性和显着的商业价值。

    MIXTURES OF HMOs
    8.
    发明申请
    MIXTURES OF HMOs 审中-公开

    公开(公告)号：US20190290667A1

    公开(公告)日：2019-09-26

    申请号：US16435949

    申请日：2019-06-10

    Applicant: Glycom A/S

    Inventor： Elise CHAMPION ,  Bruce MCCONNELL ,  Gyula DEKANY

    IPC: A61K31/702 ,  C12P19/26 ,  C07H5/06 ,  A61K31/715 ,  A61K31/7016 ,  C12P19/18

    Abstract: The invention relates to a mixture of human milk oligosaccharides that consists essentially of: a) a component A which is 3-FL or DFL, a component B which is LNT, LNnT, LNFP-I or 2′-FL, a component C, which is LNFP-II when component B is LNT, or LNFP-III when component B is LNnT, or LNDFH-I when component B is LNFP-I, or DFL when component B is 2′-FL, and a component D, which is lactose when component A is 3-FL, or 2′-FL when component A is DFL, with the proviso that if component B is 2′-FL, then component A is 3-FL; or consists essentially of: b) 3-FL, a component E which is LNT, LNnT or LNFP-I, and a component F, which is LNFP-II when component E is LNT, or LNFP-III when component E is LNnT, or LNDFH-I when component E is LNFP-I, and to processes for producing them and their uses.

    MIXTURES OF HUMAN MILK OLIGOSACCHARIDES COMPRISING 3 '-O-SIALYLLACTOSE
    9.
    发明申请
    MIXTURES OF HUMAN MILK OLIGOSACCHARIDES COMPRISING 3 '-O-SIALYLLACTOSE 审中-公开

    公开(公告)号：US20180078574A1

    公开(公告)日：2018-03-22

    申请号：US15561684

    申请日：2016-03-31

    Applicant: Glycom A/S

    Inventor： Elise CHAMPION ,  Bruce MCCONNELL ,  Gyula DEKANY

    IPC: A61K31/702 ,  A61K31/7016 ,  C12P19/26 ,  C12P19/14

    Abstract: A mixture of human milk oligosaccharides that consists essentially of 3′-O-sialyllactose, a component A which is either 3-O-fucosyllactose or lacto-N-tetraose, a component B which is 3-O-fucosyl-3′-O-sialyllactose when component A is 3-O-fucosyllactose and sialyllacto-N-tetraose a, when component A is lacto-N-tetraose and optionally lactose as a fourth component. The mixtures are made by treating 3′-O-sialyllactose and component A with an α2,3-transsialidase. The mixtures are for use in anti-bacterial and anti-viral compositions, and for promoting the development of Bifidobacterium and Barnesiella.

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