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    SEPARATION OF OLIGOSACCHARIDES FROM FERMENTATION BROTH
    2.
    发明申请
    SEPARATION OF OLIGOSACCHARIDES FROM FERMENTATION BROTH 审中-公开

    公开(公告)号：US20190119314A1

    公开(公告)日：2019-04-25

    申请号：US16094508

    申请日：2017-04-19

    Applicant: GLYCOM A/S

    Inventor： Pierre CHASSAGNE ,  Nikolay KHANZHIN ,  Martin MATWIEJUK ,  Markus JONDELIUS HEDEROS ,  Niels BANKE

    IPC: C07H13/04 ,  C07H1/06 ,  B01D61/02 ,  B01D61/14 ,  C12P19/28 ,  B01D61/58

    Abstract: The invention relates to a method for obtaining an N-acetylglucosamine containing neutral oligosaccharide from a fermentation broth, wherein said oligosaccharide is produced by culturing a genetically modified microorganism capable of producing said oligosaccharide from an internalized carbohydrate precursor, comprising the steps of: i) ultrafiltration (UF), preferably to separate biomass from the broth, ii) nanofiltration (NF), preferably to concentrate said oligosaccharide in the broth and/or reduce an inorganic salt content of the broth, and iii) treating the broth with an ion exchange resin, preferably to remove charged materials, and/or subjecting the broth to chromatography, preferably to remove hydrophobic impurities.

    SYNTHESIS OF SIALYLATED/FUCOSYLATED HUMAN MILK OLIGOSACCHARIDES
    10.
    发明申请
    SYNTHESIS OF SIALYLATED/FUCOSYLATED HUMAN MILK OLIGOSACCHARIDES 有权
    异亮氨酸/ FOSOSLIL人乳酪寡糖的合成

    公开(公告)号：US20160075729A1

    公开(公告)日：2016-03-17

    申请号：US14783783

    申请日：2014-04-11

    Applicant: GLYCOM A/S

    Inventor： Pierre CHASSAGNE ,  Nikolay KHANZHIN ,  Markus HEDEROS ,  Elise CHAMPION ,  Martin MATWIEJUK ,  Gyula DEKANY

    IPC: C07H5/04

    CPC classification number: C07H5/04 ,  C07H1/00

    Abstract: An achemo-enzymatic synthesis of oligosaccharides of formula 1 is presented wherein R is selected from —OH, —N3 and —OR6 wherein R6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, —(CH2)n—NH2 and —(CH2)n—N3 wherein integer n is to 10, preferably 2 or 3, R is selected from sialyl moiety, —SO3H and —CH(R)—COOH wherein R is selected from H, alkyl and benzyl, R2 is selected from H and fucosyl, R3 is selected from H and sialyl, R4 is selected from H and fucosyl, provided that at least one of R3 and R4 is H, and A is a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.

    Abstract translation: 其中R选自-OH，-N 3和-OR 6，其中R 6选自任选被一个或多个甲基取代的烯丙基，炔丙基任选被一个或多个甲基， 三甲基甲硅烷基 - 乙基， - （CH 2）n -NH 2和 - （CH 2）n -N 3其中整数n为10，优选2或3，R选自唾液酰基部分，-SO 3 H和-CH（R）-COOH，其中R 选自H，烷基和苄基，R2选自H和岩藻糖基，R3选自H和唾液烷基，R4选自H和岩藻糖基，条件是R3和R4中至少一个为H，A为二价 碳水化合物接头，对制药和食品工业具有重要的生物活性和显着的商业价值。

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