公开(公告)号：US11944659B2

公开(公告)日：2024-04-02

申请号：US17499261

申请日：2021-10-12

申请人： GRAPE KING BIO LTD

发明人： Chin-Chu Chen ,  I-Chen Li ,  Tsung-Ju Li ,  Ting-Yu Lu ,  Yen-Po Chen

IPC分类号： A61K36/07 ,  A23K50/50 ,  A23L31/00 ,  A23L33/10 ,  A61P21/06 ,  B01D11/02

CPC分类号： A61K36/07 ,  A23K50/50 ,  A23L31/00 ,  A23L33/10 ,  A61P21/06 ,  B01D11/0288 ,  A23V2002/00 ,  A61K2236/11 ,  A61K2236/333 ,  A61K2236/37

摘要： The invention provides a method for improving sarcopenia of a subject in need thereof by using Phellinus linteus, in which the method includes administering an effective dose of composition to the subject, and the composition includes Phellinus linteus (NITE BP-03321 and BCRC 930210) as an effective substance. By using the aforementioned composition including an extract of a fermented product of the Phellinus linteus and/or its derivative, diameters of myotubes, amounts of muscles and muscle muscular endurance can be maintained, thereby improving sarcopenia.

公开(公告)号：US11058733B2

公开(公告)日：2021-07-13

申请号：US16542608

申请日：2019-08-16

申请人： GRAPE KING BIO LTD

发明人： Chin-Chu Chen ,  Yen-Lien Chen ,  Shih-Wei Lin ,  Yen-Po Chen ,  Ci-Sian Wang ,  Yu-Hsin Hou ,  Yang-Tzu Shih ,  Ching-Wen Lin ,  Ya-Jyun Chen ,  Jia-Lin Jiang

IPC分类号： A61K35/745 ,  C12N1/20 ,  A61K9/00 ,  A23L33/135 ,  A61K35/00

摘要： The present invention provides a Bifidobacterium lactis having active substances, a composition comprising the same, and a method of promoting longevity using the same by subjecting the composition to a subject, thereby increasing Cisd2 gene expression, reducing damage of mitochondria, delaying aging-related symptoms including nerve degeneration and sarcopenia, and so on.

公开(公告)号：US11752177B2

公开(公告)日：2023-09-12

申请号：US17554626

申请日：2021-12-17

申请人： GRAPE KING BIO LTD

发明人： Chin-Chu Chen ,  Yen-Lien Chen ,  Shih-Wei Lin ,  Yen-Po Chen ,  Ci-Sian Wang ,  Yu-Hsin Hou ,  Yang-Tzu Shih ,  Ching-Wen Lin ,  Ya-Jyun Chen ,  Jia-Lin Jiang ,  You-Shan Tsai ,  Zi-He Wu

IPC分类号： A61P25/34 ,  C12N1/20 ,  A61K9/00 ,  C12R1/225 ,  A61K35/742

CPC分类号： A61K35/742 ,  A61K9/0053 ,  A61P25/34 ,  C12N1/205 ,  C12R2001/225

摘要： The present invention is related to a method of reducing tobacco addiction in a smoking subject with Lactobacillus fermentum GKF3, including daily administering an oral composition containing the Lactobacillus fermentum GKF3 to the smoking subject, in which the oral composition reduces the total amount of the nicotine metabolites in urine.

公开(公告)号：US11116807B2

公开(公告)日：2021-09-14

申请号：US16019722

申请日：2018-06-27

申请人： GRAPE KING BIO LTD.

发明人： Chin-Chu Chen ,  Szu-Yin Wu ,  Hsiao-Ling Chang ,  Yen-Po Chen

IPC分类号： A61K36/062 ,  A61P15/08 ,  A61K9/19 ,  A61K47/10 ,  A61K9/08

摘要： The present invention provides an active substance of Morchella, its use and a composition thereof for improving disturbance of reproductive function, especially, for manufacturing a pharmaceutical composition to improve disturbance of reproductive function induced by obesity or metabolic syndrome. The composition with the active substance of Morchella can effectively improve the structural integrity of testicular tissues and sperm, increase testosterone levels in the blood, and reduce the oxidation stress in sperms.

公开(公告)号：US11766465B2

公开(公告)日：2023-09-26

申请号：US17514670

申请日：2021-10-29

申请人： GRAPE KING BIO LTD

发明人： Hsing-Chun Kuo ,  Chin-Chu Chen ,  Yen-Lien Chen ,  Shih-Wei Lin ,  Yen-Po Chen ,  Ci-Sian Wang ,  Yu-Hsin Hou ,  Yang-Tzu Shih ,  Ching-Wen Lin ,  Ya-Jyun Chen ,  Jia-Lin Jiang ,  You-Shan Tsai ,  Zi-He Wu

IPC分类号： A61K35/747 ,  A61P17/02 ,  A61K9/00

CPC分类号： A61K35/747 ,  A61K9/0014 ,  A61P17/02

摘要： The present disclosure relates to as external composition for wound healing containing a Lactobacillus fermentation product, which comprises a Lactobacillus fermentation product as an effective component. The Lactobacillus fermentation product is a bacteria-free concentrated filtrate from fermentation of Lactobacillus plantarum and the effective component is loaded onto a pharmaceutically acceptable absorbent carrier or carrying agent. The external composition for wound healing has anti-inflammatory and healing promoting effects on a skin wound after applied directly onto the skin wound.

公开(公告)号：US11730783B2

公开(公告)日：2023-08-22

申请号：US17349627

申请日：2021-06-16

申请人： GRAPE KING BIO LTD.

发明人： Chin-Chu Chen ,  Szu-Yin Wu ,  Hsiao-Ling Chang ,  Yen-Po Chen

IPC分类号： A61K36/062 ,  A61P15/08 ,  A61K9/19 ,  A61K47/10 ,  A61K9/08

CPC分类号： A61K36/062 ,  A61K9/08 ,  A61K9/19 ,  A61K47/10 ,  A61P15/08

摘要： The present invention provides an active substance of Morchella, its use and a composition thereof for improving disturbance of reproductive function, especially, for manufacturing a pharmaceutical composition to improve disturbance of reproductive function induced by obesity or metabolic syndrome. The composition with the active substance of Morchella can effectively improve the structural integrity of testicular tissues and sperm, increase testosterone levels in the blood, and reduce the oxidation stress in sperms.

公开(公告)号：US11253556B2

公开(公告)日：2022-02-22

申请号：US16675667

申请日：2019-11-06

申请人： GRAPE KING BIO LTD

发明人： Chin-Chu Chen ,  Yen-Lien Chen ,  Shih-Wei Lin ,  Szu-Yin Wu ,  Yen-Po Chen ,  Yu-Hsin Hou ,  Ci-Sian Wang ,  Yang-Tzu Shih ,  Jia-Lin Jiang

IPC分类号： A61K35/747 ,  A61K35/00 ,  A61K39/09 ,  A23L29/00

摘要： The present invention provides a Lactobacillus fermentum GKF3, a composition comprising the strain and their use, in which the aforementioned Lactobacillus fermentum GKF3, deposited with accession numbers of BCRC 910824 and CGMCC 15203, can increase the levels of dopamine or/and serotonin in brain tissues, thereby improving the symptoms of the psychataxia such as decreased focus.

公开(公告)号：US11185563B2

公开(公告)日：2021-11-30

申请号：US16391777

申请日：2019-04-23

申请人： GRAPE KING BIO Ltd.

发明人： Chin-Chu Chen ,  Yen-Lien Chen ,  Shin-Wei Lin ,  Yen-Po Chen ,  Yang-Tzu Shih ,  Ching-Wen Lin

IPC分类号： A61K35/747 ,  A23L33/135 ,  A61K47/42 ,  A61K47/26 ,  A61K47/36 ,  A61P19/10 ,  A61K9/00

摘要： The present invention discloses uses of treating, preventing or improving bone diseases by Lactobacillus or a composition including the Lactobacillus. The Lactobacillus and compositions can increase the blood calcium concentration, the trabecular bone volume density, the trabecular thickness, the trabecular number and the bone mineral density of a subject, and reduce trabecular spacing of the subject. Further, the present invention discloses a method for treating a subject diagnosed with a bone disease, through identifying the subject having the bone disease and administering to the subject an effective amount of a composition including at least one of Lactobacillus plantarum GKM3 and Lactobacillus paracasei GKS6, wherein the Lactobacillus plantarum GKM3 is deposited in China General Microbiological Culture Collection Center (CGMCC) with a deposition number of CGMCC 14565 on Aug. 25, 2017, and the Lactobacillus paracasei GKS6 is deposited in CGMCC with a deposition number of CGMCC 14566 on Aug. 25, 2017.

公开(公告)号：US20190321420A1

公开(公告)日：2019-10-24

申请号：US16391777

申请日：2019-04-23

申请人： GRAPE KING BIO Ltd.

发明人： Chin-Chu Chen ,  Yen-Lien Chen ,  Shin-Wei Lin ,  Yen-Po Chen ,  Yang-Tzu Shih ,  Ching-Wen Lin

IPC分类号： A61K35/747 ,  A61P19/10 ,  A23L33/135 ,  A61K9/00

摘要： The present invention discloses uses of treating, preventing or improving bone diseases by Lactobacillus or a composition including the Lactobacillus. The Lactobacillus and compositions can increase the blood calcium concentration, the trabecular bone volume density (BV/TV ratio), the trabecular thickness (Tb.Th), the trabecular number (Tb.N) and the bone mineral density (BMD) of a subject, and reduce trabecular spacing (Tb.Sp) of the subject. Further, the present invention discloses a method for treating a subject diagnosed with a bone disease, comprises steps of identifying the subject having the bone disease, and administering to the subject an effective amount of a composition including at least one of Lactobacillus plantarum GKM3 and Lactobacillus paracasei GKS6, wherein the Lactobacillus plantarum GKM3 is deposited in China General Microbiological Culture Collection Center (CGMCC) with a deposition number of CGMCC 14565 on Aug. 25, 2017, and the Lactobacillus paracasei GKS6 is deposited in CGMCC with a deposition number of CGMCC 14566 on Aug. 25, 2017.

公开(公告)号：US11590180B2

公开(公告)日：2023-02-28

申请号：US16541964

申请日：2019-08-15

申请人： GRAPE KING BIO LTD.

发明人： Chin-Chu Chen ,  Yen-Lien Chen ,  Shin-Wei Lin ,  Yen-Po Chen ,  Ci-Sian Wang ,  Yu-Hsin Hou ,  Yang-Tzu Shih ,  Ching-Wen Lin ,  Ya-Jyun Chen ,  Jia-Lin Jiang

IPC分类号： A61P11/06 ,  A61P37/08 ,  A61K35/745 ,  A23L33/135 ,  A61K9/19 ,  A23L2/52

摘要： The present invention provides a Bifidobacterium lactis GKK2, a composition comprising thereof and its use for improving asthma, especially for lowering airway resistance, reducing levels of non-specific and specific IgE in serum, alleviating bronchoconstriction and increasing levels of GSH reductase in liver tissue interstitial fluid to improve allergic asthma.