公开(公告)号：US20240327416A1

公开(公告)日：2024-10-03

申请号：US18663318

申请日：2024-05-14

Applicant: Gruenenthal GmbH

Inventor： Florian JAKOB ,  Jo ALEN ,  Simon LUCAS ,  Tobias CRAAN ,  Ingo KONETZKI ,  Achim KLESS ,  Stefan SCHUNK ,  Paul RATCLIFFE ,  Sebastian WACHTEN ,  Simon CRUWYS

IPC: C07D487/04 ,  A61K31/4985

CPC classification number: C07D487/04 ,  A61K31/4985

Abstract: The present invention relates to compounds according to general formula (I)




which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

公开(公告)号：US20220127264A1

公开(公告)日：2022-04-28

申请号：US17568979

申请日：2022-01-05

Applicant: GRUENENTHAL GMBH

Inventor： Florian JAKOB ,  Jo Alen ,  Sebastian Krueger ,  Markus Schade ,  Daniela Friebe ,  Stephanie Hennen

IPC: C07D471/04 ,  C07D409/14 ,  C07D403/14 ,  C07D413/14 ,  A61P29/00 ,  C07D401/14 ,  C07D405/14 ,  C07D403/04 ,  C07D417/14 ,  A61P11/06 ,  A61P19/02

Abstract: The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

公开(公告)号：US20190185455A1

公开(公告)日：2019-06-20

申请号：US16223845

申请日：2018-12-18

Applicant: Gruenenthal GmbH

Inventor： Florian JAKOB ,  Jo ALEN ,  Sebastian KRÜGER ,  Markus SCHADE ,  Daniela FRIEBE ,  Stephanie HENNEN

IPC: C07D401/14 ,  C07D403/14 ,  C07D417/14 ,  C07D405/14 ,  A61P25/00 ,  A61P29/00

CPC classification number: C07D401/14 ,  A61P11/06 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

公开(公告)号：US20230183184A1

公开(公告)日：2023-06-15

申请号：US18102983

申请日：2023-01-30

Applicant: Gruenenthal GmbH

Inventor： Sven KUEHNERT ,  Rene Michael KOENIGS ,  Florian JAKOB ,  Achim KLESS ,  Anita WEGERT ,  Paul RATCLIFFE ,  Ruth JOSTOCK ,  Thomas KOCH ,  Klaus LINZ ,  Wolfgang SCHROEDER

IPC: C07D235/02 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/06 ,  C07D487/04

CPC classification number: C07D235/02 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/06 ,  C07D487/04

Abstract: The invention relates to 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US20220372041A1

公开(公告)日：2022-11-24

申请号：US17866672

申请日：2022-07-18

Applicant: GRUENENTHAL GMBH

Inventor： Jo ALEN ,  Florian JAKOB ,  Sebastian KRUEGER ,  Philipp BARBIE ,  Daniela FRIEBE ,  Stephanie HENNEN

IPC: C07D487/04 ,  C07D498/04 ,  C07D471/04 ,  C07D471/14 ,  A61P29/00

Abstract: The present invention relates to compounds according to general formula (I) which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

公开(公告)号：US20200223840A1

公开(公告)日：2020-07-16

申请号：US16740735

申请日：2020-01-13

Applicant: Gruenenthal GMBH

Inventor： Florian JAKOB ,  Jo ALEN ,  Sebastian KRÜGER ,  Daniela FRIEBE ,  Stephanie HENNEN ,  Philipp BARBIE

IPC: C07D417/14 ,  C07D403/10 ,  C07D471/04 ,  C07D409/14 ,  C07D403/14 ,  C07D413/14 ,  C07D401/14

Abstract: The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

公开(公告)号：US20180273491A1

公开(公告)日：2018-09-27

申请号：US15979932

申请日：2018-05-15

Applicant: GRUENENTHAL GMBH

Inventor： Sven KUEHNERT ,  Rene Michael KOENIGS ,  Florian JAKOB ,  Achim KLESS ,  Anita WEGERT ,  Paul RATCLIFFE ,  Ruth JOSTOCK ,  Thomas KOCH ,  Klaus LINZ ,  Wolfgang SCHROEDER

IPC: C07D235/02 ,  C07D405/12 ,  C07D487/04 ,  C07D401/06 ,  C07D403/12 ,  C07D413/12 ,  C07D403/06 ,  C07D401/12 ,  C07D417/06

CPC classification number: C07D235/02 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/06 ,  C07D487/04

Abstract: The invention relates to 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US20190185470A1

公开(公告)日：2019-06-20

申请号：US16223925

申请日：2018-12-18

Applicant: Gruenenthal GmbH

Inventor： Florian JAKOB ,  Jo ALEN ,  Sebastian KRÜGER ,  Markus SCHADE ,  Daniela FRIEBE ,  Stephanie HENNEN

IPC: C07D471/04 ,  C07D409/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D401/14 ,  C07D405/14 ,  C07D403/04 ,  A61P29/00

CPC classification number: C07D471/04 ,  A61P11/06 ,  A61P19/02 ,  A61P29/00 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

公开(公告)号：US20230174540A1

公开(公告)日：2023-06-08

申请号：US18103319

申请日：2023-01-30

Applicant: Gruenenthal GmbH

Inventor： Sven KUEHNERT ,  Rene Michael KOENIGS ,  Florian JAKOB ,  Achim KLESS ,  Paul RATCLIFFE ,  Ruth JOSTOCK ,  Thomas KOCH ,  Klaus LINZ ,  Wolfgang SCHROEDER ,  Klaus SCHIENE ,  Anita WEGERT

IPC: C07D487/04 ,  C07D235/02 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12 ,  C07K5/062

CPC classification number: C07D487/04 ,  C07D235/02 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12 ,  C07K5/06026

Abstract: The invention relates to 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US20220396578A1

公开(公告)日：2022-12-15

申请号：US17866670

申请日：2022-07-18

Applicant: GRUENENTHAL GMBH

Inventor： Jo ALEN ,  Florian JAKOB ,  Sebastian KRUEGER ,  Daniela FRIEBE ,  Stephanie HENNEN

IPC: C07D487/04 ,  C07D491/147 ,  C07D519/00

Abstract: The present invention relates to compounds according to general formula (I) which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.