公开(公告)号：US20240327416A1

公开(公告)日：2024-10-03

申请号：US18663318

申请日：2024-05-14

Applicant: Gruenenthal GmbH

Inventor： Florian JAKOB ,  Jo ALEN ,  Simon LUCAS ,  Tobias CRAAN ,  Ingo KONETZKI ,  Achim KLESS ,  Stefan SCHUNK ,  Paul RATCLIFFE ,  Sebastian WACHTEN ,  Simon CRUWYS

IPC: C07D487/04 ,  A61K31/4985

CPC classification number: C07D487/04 ,  A61K31/4985

Abstract: The present invention relates to compounds according to general formula (I)




which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

公开(公告)号：US20190185455A1

公开(公告)日：2019-06-20

申请号：US16223845

申请日：2018-12-18

Applicant: Gruenenthal GmbH

Inventor： Florian JAKOB ,  Jo ALEN ,  Sebastian KRÜGER ,  Markus SCHADE ,  Daniela FRIEBE ,  Stephanie HENNEN

IPC: C07D401/14 ,  C07D403/14 ,  C07D417/14 ,  C07D405/14 ,  A61P25/00 ,  A61P29/00

CPC classification number: C07D401/14 ,  A61P11/06 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

公开(公告)号：US20190185470A1

公开(公告)日：2019-06-20

申请号：US16223925

申请日：2018-12-18

Applicant: Gruenenthal GmbH

Inventor： Florian JAKOB ,  Jo ALEN ,  Sebastian KRÜGER ,  Markus SCHADE ,  Daniela FRIEBE ,  Stephanie HENNEN

IPC: C07D471/04 ,  C07D409/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D401/14 ,  C07D405/14 ,  C07D403/04 ,  A61P29/00

CPC classification number: C07D471/04 ,  A61P11/06 ,  A61P19/02 ,  A61P29/00 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

公开(公告)号：US20230265078A1

公开(公告)日：2023-08-24

申请号：US18015251

申请日：2021-07-09

Applicant: Gruenenthal GmbH

Inventor： Jo ALEN ,  Florian JAKOB ,  Sebastian KRUEGER ,  Philipp BARBIE

IPC: C07D403/04 ,  C07D417/04 ,  C07D417/14 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14

CPC classification number: C07D403/04 ,  C07D417/04 ,  C07D417/14 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14

Abstract: The invention relates to compounds according to general formula (I)




which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

公开(公告)号：US20220106295A1

公开(公告)日：2022-04-07

申请号：US17554702

申请日：2021-12-17

Applicant: GRUENENTHAL GMBH

Inventor： Florian JAKOB ,  Jo ALEN ,  Sebastian KRUEGER ,  Daniela FRIEBE ,  Stephanie HENNEN

IPC: C07D403/04 ,  C07D471/04 ,  C07D413/04 ,  C07D413/14 ,  C07D405/04 ,  C07D207/12 ,  C07D417/04

Abstract: The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

公开(公告)号：US20220372041A1

公开(公告)日：2022-11-24

申请号：US17866672

申请日：2022-07-18

Applicant: GRUENENTHAL GMBH

Inventor： Jo ALEN ,  Florian JAKOB ,  Sebastian KRUEGER ,  Philipp BARBIE ,  Daniela FRIEBE ,  Stephanie HENNEN

IPC: C07D487/04 ,  C07D498/04 ,  C07D471/04 ,  C07D471/14 ,  A61P29/00

Abstract: The present invention relates to compounds according to general formula (I) which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

公开(公告)号：US20200223840A1

公开(公告)日：2020-07-16

申请号：US16740735

申请日：2020-01-13

Applicant: Gruenenthal GMBH

Inventor： Florian JAKOB ,  Jo ALEN ,  Sebastian KRÜGER ,  Daniela FRIEBE ,  Stephanie HENNEN ,  Philipp BARBIE

IPC: C07D417/14 ,  C07D403/10 ,  C07D471/04 ,  C07D409/14 ,  C07D403/14 ,  C07D413/14 ,  C07D401/14

Abstract: The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

公开(公告)号：US20230025025A1

公开(公告)日：2023-01-26

申请号：US17840712

申请日：2022-06-15

Applicant: GRUENENTHAL GMBH

Inventor： Sebastian KRUEGER ,  Sebastian PEIL ,  Clemens DIALER ,  Marcel MUELBAIER ,  Markus WAGENER ,  Ingo KONETZKI ,  Nikolay SITNIKOV ,  Jo ALEN ,  Martin PETTERSSON

IPC: C07D231/14 ,  C07D401/12 ,  C07D405/06 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12

Abstract: The present invention relates to compounds according to general formula (I) which act as inhibitors of NaV1.8 and can be used in the treatment of pain.

公开(公告)号：US20220396578A1

公开(公告)日：2022-12-15

申请号：US17866670

申请日：2022-07-18

Applicant: GRUENENTHAL GMBH

Inventor： Jo ALEN ,  Florian JAKOB ,  Sebastian KRUEGER ,  Daniela FRIEBE ,  Stephanie HENNEN

IPC: C07D487/04 ,  C07D491/147 ,  C07D519/00

Abstract: The present invention relates to compounds according to general formula (I) which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

公开(公告)号：US20220106294A1

公开(公告)日：2022-04-07

申请号：US17554729

申请日：2021-12-17

Applicant: GRUENENTHAL GMBH

Inventor： Florian JAKOB ,  Jo ALEN ,  Sebastian KRUEGER ,  Philipp BARBIE ,  Daniela FRIEBE

IPC: C07D401/14 ,  C07D403/04 ,  C07D401/04 ,  C07D403/14 ,  C07D405/14 ,  C07D405/04

Abstract: The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.