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    Polynucleotides encoding novel PCSK9 variants
    1.
    发明申请
    Polynucleotides encoding novel PCSK9 variants 有权
    编码新型PCSK9变体的多核苷酸

    公开(公告)号：US20100003736A1

    公开(公告)日：2010-01-07

    申请号：US12456798

    申请日：2009-06-23

    申请人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

    发明人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

    IPC分类号： C12N9/50 ,  C12N9/96

    CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/41 ,  C07K2317/76 ,  C12N9/6424 ,  C12Y302/01008 ,  C12Y304/21061 ,  Y10T436/143333

    摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    PCSK9 polypeptides
    3.
    发明授权
    PCSK9 polypeptides 有权
    PCSK9多肽

    公开(公告)号：US07846706B2

    公开(公告)日：2010-12-07

    申请号：US12456798

    申请日：2009-06-23

    申请人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

    发明人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

    IPC分类号： C12N9/00 ,  C12N9/50 ,  C12N1/20 ,  C12N15/00 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/41 ,  C07K2317/76 ,  C12N9/6424 ,  C12Y302/01008 ,  C12Y304/21061 ,  Y10T436/143333

    摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding novel PCSK9 variants
    5.
    发明授权
    Polynucleotides encoding novel PCSK9 variants 有权
    编码新型PCSK9变体的多核苷酸

    公开(公告)号：US07572618B2

    公开(公告)日：2009-08-11

    申请号：US11824461

    申请日：2007-06-28

    申请人： Gabriel A. Mintier ,  Jian Chen ,  Bowman Miao ,  Rex Arnold Parker

    发明人： Gabriel A. Mintier ,  Jian Chen ,  Bowman Miao ,  Rex Arnold Parker

    IPC分类号： C12N9/50 ,  C12N9/00 ,  C12N1/20 ,  C12N15/00 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/41 ,  C07K2317/76 ,  C12N9/6424 ,  C12Y302/01008 ,  C12Y304/21061 ,  Y10T436/143333

    摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    POLYNUCLEOTIDES ENCODING NOVEL PCSK9 VARIANTS
    7.
    发明申请
    POLYNUCLEOTIDES ENCODING NOVEL PCSK9 VARIANTS 有权
    多核苷酸编码新的PCSK9变体

    公开(公告)号：US20120129237A1

    公开(公告)日：2012-05-24

    申请号：US13336371

    申请日：2011-12-23

    申请人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

    发明人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

    IPC分类号： C12N9/64 ,  C12N9/96

    CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/41 ,  C07K2317/76 ,  C12N9/6424 ,  C12Y302/01008 ,  C12Y304/21061 ,  Y10T436/143333

    摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。