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    PCSK9 polypeptides
    2.
    发明授权
    PCSK9 polypeptides 有权
    PCSK9多肽

    公开(公告)号：US07846706B2

    公开(公告)日：2010-12-07

    申请号：US12456798

    申请日：2009-06-23

    申请人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

    发明人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

    IPC分类号： C12N9/00 ,  C12N9/50 ,  C12N1/20 ,  C12N15/00 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/41 ,  C07K2317/76 ,  C12N9/6424 ,  C12Y302/01008 ,  C12Y304/21061 ,  Y10T436/143333

    摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding novel PCSK9 variants
    4.
    发明授权
    Polynucleotides encoding novel PCSK9 variants 有权
    编码新型PCSK9变体的多核苷酸

    公开(公告)号：US07572618B2

    公开(公告)日：2009-08-11

    申请号：US11824461

    申请日：2007-06-28

    申请人： Gabriel A. Mintier ,  Jian Chen ,  Bowman Miao ,  Rex Arnold Parker

    发明人： Gabriel A. Mintier ,  Jian Chen ,  Bowman Miao ,  Rex Arnold Parker

    IPC分类号： C12N9/50 ,  C12N9/00 ,  C12N1/20 ,  C12N15/00 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/41 ,  C07K2317/76 ,  C12N9/6424 ,  C12Y302/01008 ,  C12Y304/21061 ,  Y10T436/143333

    摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    POLYNUCLEOTIDES ENCODING NOVEL PCSK9 VARIANTS
    6.
    发明申请
    POLYNUCLEOTIDES ENCODING NOVEL PCSK9 VARIANTS 有权
    多核苷酸编码新的PCSK9变体

    公开(公告)号：US20120129237A1

    公开(公告)日：2012-05-24

    申请号：US13336371

    申请日：2011-12-23

    申请人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

    发明人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

    IPC分类号： C12N9/64 ,  C12N9/96

    CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/41 ,  C07K2317/76 ,  C12N9/6424 ,  C12Y302/01008 ,  C12Y304/21061 ,  Y10T436/143333

    摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding novel PCSK9 variants
    7.
    发明申请
    Polynucleotides encoding novel PCSK9 variants 有权
    编码新型PCSK9变体的多核苷酸

    公开(公告)号：US20100003736A1

    公开(公告)日：2010-01-07

    申请号：US12456798

    申请日：2009-06-23

    申请人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

    发明人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

    IPC分类号： C12N9/50 ,  C12N9/96

    CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/41 ,  C07K2317/76 ,  C12N9/6424 ,  C12Y302/01008 ,  C12Y304/21061 ,  Y10T436/143333

    摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Step-stool
    9.
    外观设计
    Step-stool 有权

    公开(公告)号：USD1008676S1

    公开(公告)日：2023-12-26

    申请号：US29820654

    申请日：2021-12-23

    申请人： Jian Chen

    设计人： Jian Chen

    摘要： FIG. 1 is a perspective view of a step-stool showing my new design;
    FIG. 2 is a front view thereof;
    FIG. 3 is a rear view thereof;
    FIG. 4 is a left side view thereof;
    FIG. 5 is a right side view thereof;
    FIG. 6 is a top view thereof;
    FIG. 7 is a bottom view thereof;
    FIG. 8 is a bottom side perspective view thereof; and,
    FIG. 9 is a perspective view of the step-stool of FIG. 1, shown with unclaimed patterned ornamentation.
    The broken lines in the drawings depict portions of the step-stool that form no part of the claimed design.

    Shock Tube and Cell Electroporation Device with the Shock Tube
    10.
    发明申请
    Shock Tube and Cell Electroporation Device with the Shock Tube 审中-公开

    公开(公告)号：US20200032191A1

    公开(公告)日：2020-01-30

    申请号：US16586989

    申请日：2019-09-29

    申请人： Jian Chen

    发明人： Jian Chen

    IPC分类号： C12M1/42 ,  C12M1/12 ,  B01L3/00

    摘要： The shock tube comprises a tube, a first electrode, a second electrode and a stopple, wherein the tube is internally provided with a cavity for accommodating a target liquid sample. The first electrode is arranged at one end of the tube. The second electrode is arranged in the stopple, and the outer end of the second electrode can be electrically connected with the exterior via an opening of the stopple. The stopple is internally provided with an elastic piece connected with the second electrode. The outer side of the elastic piece is connected with the stopple, and the inner side of the elastic piece is connected with the second electrode. The invention further provides a cell electroporation device where the shock tube can be placed.