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    ASC as a marker for colorectal cancer
    8.
    发明申请
    ASC as a marker for colorectal cancer 有权
    ASC作为结肠直肠癌的标志物

    公开(公告)号：US20090155820A1

    公开(公告)日：2009-06-18

    申请号：US11820769

    申请日：2007-06-20

    申请人： Herbert Andres ,  Marie-Luise Hagmann ,  Johann Karl ,  Ursula Kunert ,  Gabriele Pestlin

    发明人： Herbert Andres ,  Marie-Luise Hagmann ,  Johann Karl ,  Ursula Kunert ,  Gabriele Pestlin

    IPC分类号： G01N33/574 ,  C12Q1/34 ,  C12Q1/48

    CPC分类号： G01N33/57419

    摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein ASC (apoptosis-associated speck-like protein containing a caspase-associated recruitment domain) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring ASC in said sample. Measurement of ASC can, e.g., be used in the early detection or diagnosis of colorectal cancer.

    摘要翻译： 本发明涉及结肠直肠癌的诊断。 它公开了在结直肠癌诊断中使用蛋白质ASC（含凋亡相关的斑点状蛋白质，含有胱天蛋白酶相关募集域）。 它涉及一种通过测量所述样品中的ASC从个体衍生的来自液体样品的结肠直肠癌的诊断方法。 ASC的测量可以例如用于结肠直肠癌的早期检测或诊断。

    ASC as a marker for colorectal cancer
    9.
    发明授权
    ASC as a marker for colorectal cancer 有权
    ASC作为结肠直肠癌的标志物

    公开(公告)号：US07846653B2

    公开(公告)日：2010-12-07

    申请号：US11820769

    申请日：2007-06-20

    申请人： Herbert Andres ,  Marie-Luise Hagmann ,  Johann Karl ,  Ursula Kunert ,  Gabriele Pestlin

    发明人： Herbert Andres ,  Marie-Luise Hagmann ,  Johann Karl ,  Ursula Kunert ,  Gabriele Pestlin

    IPC分类号： C12Q1/00 ,  G01N33/574

    CPC分类号： G01N33/57419

    摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein ASC (apoptosis-associated speck-like protein containing a caspase-associated recruitment domain) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring ASC in said sample. Measurement of ASC can, e.g., be used in the early detection or diagnosis of colorectal cancer.

    摘要翻译： 本发明涉及结肠直肠癌的诊断。 它公开了在结直肠癌诊断中使用蛋白质ASC（含凋亡相关的斑点状蛋白质，含有胱天蛋白酶相关募集域）。 它涉及一种通过测量所述样品中的ASC从个体衍生的来自液体样品的结肠直肠癌的诊断方法。 ASC的测量可以例如用于结肠直肠癌的早期检测或诊断。

    Process for making antifusogenic fusion peptides that form inclusion bodies
    10.
    发明申请
    Process for making antifusogenic fusion peptides that form inclusion bodies 有权
    制造形成包涵体的抗融合融合肽的方法

    公开(公告)号：US20050058659A1

    公开(公告)日：2005-03-17

    申请号：US10969624

    申请日：2004-10-20

    申请人： Eva Hoess ,  Thomas Meier ,  Gabriele Pestlin ,  Friedrich Popp ,  Klaus Reichert ,  Rainer Schmuck ,  Bernd Schneidinger ,  Christoph Seidel ,  Wilhelm Tischer

    发明人： Eva Hoess ,  Thomas Meier ,  Gabriele Pestlin ,  Friedrich Popp ,  Klaus Reichert ,  Rainer Schmuck ,  Bernd Schneidinger ,  Christoph Seidel ,  Wilhelm Tischer

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61P31/12 ,  A61P31/18 ,  C07K14/155 ,  C07K14/16 ,  C12N1/21 ,  C12N15/62 ,  C12P21/02 ,  C12Q1/70 ,  A61K39/21 ,  C07H21/04

    CPC分类号： C07K14/005 ,  C07K2319/00 ,  C12N2740/15022 ,  C12N2740/16122 ,  C12P21/02

    摘要： A process is disclosed for the production of an antifusogenic peptide by producing a fusion peptide of a length of about 14 to 70 amino acids in a prokaryotic host cell, comprising the steps, under such conditions that inclusion bodies of said fusion peptide are formed, of: (a) expressing in said host cell a nucleic acid encoding said fusion peptide consisting of a first peptide which is an antifusogenic peptide of a length of about 10 to 50 amino acids and a second peptide of a length of about 4 to 30 amino acids, said first peptide being N-terminally linked to said second peptide; (b) cultivating said host cell to produce said inclusion bodies; and (c) recovering said antifusogenic peptide from said inclusion bodies, wherein said recovered antifusogenic peptide consists of said fusion peptide or a peptide comprising the antifusogenic peptide of about 10 to 50 amino acids and which is a fragment cleaved from said fusion peptide. Inclusion bodies of the peptides are disclosed. Also disclosed is a nucleic acid encoding the fusion peptide consisting of a first peptide which is an antifusogenic peptide selected from the group of SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, and said sequences further consisting of glycine at the C terminal end, N-terminally linked to the second peptide.

    摘要翻译： 公开了通过在原核宿主细胞中产生约14至70个氨基酸长度的融合肽来生产抗融合肽的方法，包括以下步骤：在形成所述融合肽的包涵体的条件下， （a）在所述宿主细胞中表达编码所述融合肽的核酸，所述融合肽由长度为约10至50个氨基酸的抗融合肽的第一肽和长度为约4-30个氨基酸的第二个肽组成 所述第一肽与所述第二肽N-末端连接; （b）培养所述宿主细胞以产生所述包涵体; 和（c）从所述包涵体中回收所述抗融合肽，其中所述回收的抗融合肽由所述融合肽或包含约10至50个氨基酸的抗融合肽的肽组成，并且是从所述融合肽切割的片段。 公开了肽的包涵体。 还公开了编码由第一肽组成的融合肽的核酸，第一肽是选自SEQ ID NO：7，SEQ ID NO：8，SEQ ID NO：9，SEQ ID NO：10的抗融合肽， 所述序列进一步由C末端的甘氨酸组成，N-末端与第二肽连接。