公开(公告)号：US10077321B2

公开(公告)日：2018-09-18

申请号：US14901546

申请日：2013-06-28

申请人： GALDERMA S.A.

发明人： Morgan Karlsson ,  Anne Helander Kenne ,  Åke Öhrlund

IPC分类号： A61K31/728 ,  A61K8/04 ,  A61K8/73 ,  A61K9/00 ,  A61Q19/00 ,  C08B37/08 ,  D01F9/00 ,  A61Q19/08

CPC分类号： C08B37/0072 ,  A61K8/042 ,  A61K8/735 ,  A61K9/0024 ,  A61K31/728 ,  A61K2800/91 ,  A61Q19/00 ,  A61Q19/08 ,  D01F9/00

摘要： A method for manufacturing a shaped cross-linked hyaluronic acid product, the method including the step of subjecting a non-cross-linked precipitated hyaluronic acid substrate in a desired shape to a single cross-linking reaction in a liquid medium having a pH of 11.5 or higher and including one or more polyfunctional cross-linking agent(s) and an amount of one or more organic solvent(s) giving precipitating conditions for hyaluronic acid, under suitable conditions to obtain a precipitated, shaped cross-linked hyaluronic acid product having a degree of modification of 1-40 cross-linking agent units per 1000 disaccharide units.

公开(公告)号：US20200247913A1

公开(公告)日：2020-08-06

申请号：US16781264

申请日：2020-02-04

申请人： Galderma S.A.

发明人： Morgan Karlsson ,  Anne Helander Kenne ,  Åke Öhrlund

IPC分类号： C08B37/08 ,  D01F9/00 ,  A61Q19/00 ,  A61K31/728 ,  A61K9/00 ,  A61K8/73 ,  A61K8/04 ,  A61Q19/08

摘要： A method for manufacturing a shaped cross-linked hyaluronic acid product including the step of subjecting a non-cross-linked precipitated hyaluronic acid substrate in a desired shape to a single cross-linking reaction in a liquid medium having a pH of 11.5 or higher and including one or more polyfunctional cross-linking agent(s) and an amount of one or more organic solvent(s) giving precipitating conditions for hyaluronic acid, under suitable conditions to obtain a precipitated, shaped cross-linked hyaluronic acid product having a degree of modification of 1-40 cross-linking agent units per 1000 disaccharide units.

公开(公告)号：US20180362670A1

公开(公告)日：2018-12-20

申请号：US16111561

申请日：2018-08-24

申请人： Galderma S.A.

发明人： Morgan Karlsson ,  Anne Helander Kenne ,  Åke Öhrlund

IPC分类号： C08B37/08 ,  A61K31/728 ,  D01F9/00 ,  A61K8/04 ,  A61K8/73 ,  A61K9/00 ,  A61Q19/00 ,  A61Q19/08

摘要： A method for manufacturing a shaped cross-linked hyaluronic acid product including the step of subjecting a non-cross-linked precipitated hyaluronic acid substrate in a desired shape to a single cross-linking reaction in a liquid medium having a pH of 11.5 or higher and including one or more polyfunctional cross-linking agent(s) and an amount of one or more organic solvent(s) giving precipitating conditions for hyaluronic acid, under suitable conditions to obtain a precipitated, shaped cross-linked hyaluronic acid product having a degree of modification of 1-40 cross-linking agent units per 1000 disaccharide units.

公开(公告)号：US10077320B2

公开(公告)日：2018-09-18

申请号：US14901462

申请日：2014-06-05

申请人： GALDERMA S.A.

发明人： Morgan Karlsson ,  Katarina Edsman

IPC分类号： C08B37/08 ,  C08J3/075 ,  C08J3/24 ,  A61K9/06 ,  A61K8/04 ,  A61Q19/00 ,  A61K8/73 ,  A61K31/728

CPC分类号： C08B37/0072 ,  A61K8/042 ,  A61K8/735 ,  A61K9/06 ,  A61K31/728 ,  A61Q19/00 ,  C08J3/075 ,  C08J3/244 ,  C08J2305/08

摘要： Efficient cross-linking of hyaluronic acid (HA) is provided by a manufacturing process. In the process, HA is activated by an initial cross-linking in an aqueous solution. Unreacted cross-linking agent is removed from the activated HA. Cross-linking of the activated HA is finalized, without addition of any additional cross-linking agent, in a suspension of a liquid precipitating medium and the activated HA in precipitated form. The resulting cross-linked HA products exhibit high effective cross-linker ratio and other favorable properties, making the products useful as implants and in medical and cosmetic surgery.