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    COMPENSATION OF MOTION-RELATED ERROR IN A STREAM OF MOVING MICRO-ENTITIES
    3.
    发明申请
    COMPENSATION OF MOTION-RELATED ERROR IN A STREAM OF MOVING MICRO-ENTITIES 有权
    移动微型实体流程中运动相关错误的补偿

    公开(公告)号：US20140212917A1

    公开(公告)日：2014-07-31

    申请号：US14240830

    申请日：2012-08-24

    申请人： Gary Durack ,  Stephen D. Fleischer ,  Jeremy Hatcher ,  David Roberts ,  Michael Zordan

    发明人： Gary Durack ,  Stephen D. Fleischer ,  Jeremy Hatcher ,  David Roberts ,  Michael Zordan

    IPC分类号： G01N15/14

    CPC分类号： G01N15/1404 ,  G01N15/1427 ,  G01N15/1429 ,  G01N15/1459 ,  G01N2015/1006 ,  G01N2015/1075 ,  G01N2015/1415 ,  G01N2015/1438 ,  G01N2015/1477 ,  G01N2015/149

    摘要： Apparatus and methods for detecting, characterizing, and compensating motion-related error of moving micro-entities are described. Motion-related error may occur in streams of moving micro-entities, and may represent a deviation in and expected arrival time or an uncertainty in position of a micro-entity within the stream. Motion-related error of micro-entities is observed in a flow cytometer, e.g., as pulse jitter, and is found to have a functional dependence on a parameter of the system. The pulse jitter can be compensated, according to one embodiment, by adjusting data acquisition observation windows. For the flow cytometer, a reduction of pulse jitter can improve measurement accuracy, resolution of doublets, system throughput, and enable an increase in an interrogation region for probing the micro-entities.

    摘要翻译： 描述了移动微实体的检测，表征和补偿运动相关误差的装置和方法。 运动相关错误可能发生在移动的微实体的流中，并且可以表示流中的微实体的偏差和预期到达时间或位置的不确定性。 在流式细胞仪中观察到微实体的运动相关误差，例如作为脉冲抖动，并且被发现具有对系统的参数的功能依赖性。 根据一个实施例，可以通过调整数据采集观察窗来补偿脉冲抖动。 对于流式细胞仪，脉冲抖动的减少可以提高测量精度，双峰分辨率，系统吞吐量，并且能够增加用于探测微实体的询问区域。

    HYBRID MICROFLUIDIC SPR AND MOLECULAR IMAGING DEVICE
    4.
    发明申请
    HYBRID MICROFLUIDIC SPR AND MOLECULAR IMAGING DEVICE 审中-公开
    混合微流感SPR和分子成像装置

    公开(公告)号：US20110039280A1

    公开(公告)日：2011-02-17

    申请号：US12740087

    申请日：2008-10-29

    申请人： James F. Leary ,  Kinam Park ,  Ghanashyam Acharya ,  Michael Zordan

    发明人： James F. Leary ,  Kinam Park ,  Ghanashyam Acharya ,  Michael Zordan

    IPC分类号： G01N33/569 ,  C12M1/34

    CPC分类号： G01N33/54373 ,  G01N21/253 ,  G01N21/553 ,  G01N21/6452 ,  G01N21/6458 ,  G01N21/648

    摘要： A hybrid microfluidic biochip designed to perform multiplexed detection of singled- celled pathogens using a combination of SPR and epi-fluorescence imaging. The device comprises an array of gold spots, each functionalized with a capture biomolecule targeting a specific pathogen. This biosensor array is enclosed by a polydimethylsiloxane (PDMS) microfluidic flow chamber that delivers a magnetically concentrated sample to be tested. The sample is imaged by surface plasmon resonance on the bottom of the biochip, and epi- fluorescence on the top.

    摘要翻译： 一种混合微流体生物芯片，设计用于使用SPR和外荧光成像的组合对单细胞病原体进行多重检测。 该装置包括金点阵列，每个金点用针对特定病原体的俘获生物分子功能化。 该生物传感器阵列由聚二甲基硅氧烷（PDMS）微流体流动室包围，其传送磁性浓缩待测样品。 样品通过生物芯片底部的表面等离子体共振进行成像，顶部呈现荧光。