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公开(公告)号：US09897530B2
公开(公告)日：2018-02-20
申请号：US14240830
申请日：2012-08-24
CPC分类号： G01N15/1404 , G01N15/1427 , G01N15/1429 , G01N15/1459 , G01N2015/1006 , G01N2015/1075 , G01N2015/1415 , G01N2015/1438 , G01N2015/1477 , G01N2015/149
摘要： Apparatus and methods for detecting, characterizing, and compensating motion-related error of moving micro-entities are described. Motion-related error may occur in streams of moving micro-entities, and may represent a deviation in and expected arrival time or an uncertainty in position of a micro-entity within the stream. Motion-related error of micro-entities is observed in a flow cytometer, e.g., as pulse jitter, and is found to have a functional dependence on a parameter of the system. The pulse jitter can be compensated, according to one embodiment, by adjusting data acquisition observation windows. For the flow cytometer, a reduction of pulse jitter can improve measurement accuracy, resolution of doublets, system throughput, and enable an increase in an interrogation region for probing the micro-entities.
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2.发明申请CHARACTERIZATION OF MOTION-RELATED ERROR IN A STREAM OF MOVING MICRO-ENTITIES 审中-公开移动微型实体流动中运动相关误差的表征公开(公告)号：US20140220621A1
公开(公告)日：2014-08-07
申请号：US14240870
申请日：2012-08-24
IPC分类号： G01N15/14
CPC分类号： G01N15/1404 , G01N15/1427 , G01N15/1429 , G01N15/1459 , G01N2015/1006 , G01N2015/1075 , G01N2015/1415 , G01N2015/1438 , G01N2015/1477 , G01N2015/149
摘要： Apparatus and methods for detecting and characterizing motion-related error of moving micro-entities are described. Motion-related error may occur in streams of moving micro-entities, and may represent a deviation in and expected arrival time or an uncertainty in position of a micro-entity. Motion-related error of micro-entities is observed in a flow cytometer, e.g., as pulse jitter, and is found to have a functional dependence on a parameter related to a system clock. The motion-related error may be characterized by correlating measurements of micro-entities moving within a fluid stream.
摘要翻译： 描述了移动微实体检测和表征运动相关误差的装置和方法。 运动相关错误可能发生在移动微实体的流中，并且可能表示微实体的偏差和预期的到达时间或位置的不确定性。 在流式细胞仪中观察到微实体的运动相关误差，例如作为脉冲抖动，并且发现具有与系统时钟相关的参数的功能依赖性。 运动相关误差的特征可以在于在流体流内移动的微实体的测量值相关联。
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3.发明申请公开(公告)号：US20140212917A1
公开(公告)日：2014-07-31
申请号：US14240830
申请日：2012-08-24
IPC分类号： G01N15/14
CPC分类号： G01N15/1404 , G01N15/1427 , G01N15/1429 , G01N15/1459 , G01N2015/1006 , G01N2015/1075 , G01N2015/1415 , G01N2015/1438 , G01N2015/1477 , G01N2015/149
摘要： Apparatus and methods for detecting, characterizing, and compensating motion-related error of moving micro-entities are described. Motion-related error may occur in streams of moving micro-entities, and may represent a deviation in and expected arrival time or an uncertainty in position of a micro-entity within the stream. Motion-related error of micro-entities is observed in a flow cytometer, e.g., as pulse jitter, and is found to have a functional dependence on a parameter of the system. The pulse jitter can be compensated, according to one embodiment, by adjusting data acquisition observation windows. For the flow cytometer, a reduction of pulse jitter can improve measurement accuracy, resolution of doublets, system throughput, and enable an increase in an interrogation region for probing the micro-entities.
摘要翻译： 描述了移动微实体的检测，表征和补偿运动相关误差的装置和方法。 运动相关错误可能发生在移动的微实体的流中，并且可以表示流中的微实体的偏差和预期到达时间或位置的不确定性。 在流式细胞仪中观察到微实体的运动相关误差，例如作为脉冲抖动，并且被发现具有对系统的参数的功能依赖性。 根据一个实施例，可以通过调整数据采集观察窗来补偿脉冲抖动。 对于流式细胞仪，脉冲抖动的减少可以提高测量精度，双峰分辨率，系统吞吐量，并且能够增加用于探测微实体的询问区域。
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4.发明申请SYSTEM AND METHOD FOR THE MEASUREMENT OF MULTIPLE FLUORESCENCE EMISSIONS IN A FLOW CYTOMETRY SYSTEM 有权用于测量流动细胞计数系统中多种荧光发射的系统和方法公开(公告)号：US20080213915A1
公开(公告)日：2008-09-04
申请号：US11738860
申请日：2007-04-23
申请人： Gary Durack , Jeremy Hatcher
发明人： Gary Durack , Jeremy Hatcher
CPC分类号： G01N15/1459
摘要： A system and method for the measurement of multiple fluorescence emissions in a flow cytometry system is disclosed where each excitation light source is modulated with a different frequency. A single detector is used to collect the fluorescent emissions excited by all light sources, and the emissions are segregated using Fourier Transform techniques. Systems and methods for the correction of inter-beam coincidence are also disclosed.
摘要翻译： 公开了一种在流式细胞仪系统中测量多种荧光发射的系统和方法，其中每个激发光源以不同的频率进行调制。 使用单个检测器来收集由所有光源激发的荧光发射，并且使用傅里叶变换技术将发射分离。 还公开了用于校正光束间重合的系统和方法。
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5.发明申请Apparatus, methods and processes for sorting particles and for providing sex-sorted animal sperm 有权用于分选颗粒和提供性别分类的动物精子的装置，方法和方法公开(公告)号：US20050112541A1
公开(公告)日：2005-05-26
申请号：US10812351
申请日：2004-03-29
申请人： Gary Durack , Jeffrey Wallace , Gary Vandre , Lon Westfall , Jeremy Hatcher , Niraj Nayak
发明人： Gary Durack , Jeffrey Wallace , Gary Vandre , Lon Westfall , Jeremy Hatcher , Niraj Nayak
IPC分类号： A01N1/02 , C12M1/34 , C12N5/071 , C12Q1/04 , G01N1/30 , G01N15/00 , G01N15/14 , G01N33/48 , G01N33/487 , G01N33/50
CPC分类号： C12N5/0612 , A01N1/0284 , C12N5/06 , C12N5/061 , C12Q1/02 , C12Q3/00 , G01N15/1468 , G01N15/147 , G01N21/63 , G01N21/6428 , G01N33/48 , G01N33/5005 , G01N2015/0065 , G01N2015/1006 , G01N2015/149 , G01N2021/6439 , Y10T436/10 , Y10T436/115831 , Y10T436/12 , Y10T436/25 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： A multi-channel apparatus for classifying particles according to one or more particle characteristics. The apparatus comprises a plurality of flow cytometry units, each of which is operable to classify particles in a mixture of particles by interrogating a stream of fluid containing the particles with a beam of electromagnetic radiation. The flow cytometry units share an integrated platform comprising at least one of the following: (1) a common supply of particles; (2) a common housing; (3) a common processor for controlling operation of the units; (4) a common processor for receiving and processing information from the units; and (5) a common fluid delivery system. The integrated platform can include a common source of electromagnetic radiation. A method of the invention comprises using a plurality of flow cytometry units sharing the integrated platform to perform a flow kilometric operation, such as analyzing or sorting particles.
摘要翻译： 一种用于根据一种或多种颗粒特性分级颗粒的多通道装置。 该装置包括多个流式细胞术单元，每个流式细胞术单元可操作以通过用电磁辐射束询问含有颗粒的流体流来分类颗粒混合物中的颗粒。 流式细胞术单元共享包括以下至少一个的综合平台：（1）通常的颗粒供应; （2）共同住房; （3）用于控制单元的操作的通用处理器; （4）用于从各单元接收和处理信息的通用处理器; 和（5）普通流体输送系统。 集成平台可以包括电磁辐射的共同来源。 本发明的方法包括使用共享该集成平台的多个流式细胞仪单元来进行诸如分析或分选颗粒的流量计操作。
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6.发明授权System and method for the measurement of multiple fluorescence emissions in a flow cytometry system 有权用于测量流式细胞术系统中多种荧光发射的系统和方法公开(公告)号：US08389291B2
公开(公告)日：2013-03-05
申请号：US13329555
申请日：2011-12-19
申请人： Gary Durack , Jeremy Hatcher
发明人： Gary Durack , Jeremy Hatcher
CPC分类号： G01N15/1459
摘要： A system and method for the measurement of multiple fluorescence emissions in a flow cytometry system is disclosed where each excitation light source is modulated with a different frequency. A single detector is used to collect the fluorescent emissions excited by all light sources, and the emissions are segregated using Fourier Transform techniques. Systems and methods for the correction of inter-beam coincidence are also disclosed.
摘要翻译： 公开了一种在流式细胞仪系统中测量多种荧光发射的系统和方法，其中每个激发光源以不同的频率进行调制。 使用单个检测器来收集由所有光源激发的荧光发射，并且使用傅里叶变换技术将发射分离。 还公开了用于校正光束间重合的系统和方法。
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7.发明授权System and method for the measurement of multiple fluorescence emissions in a flow cytometry system 有权用于测量流式细胞术系统中多种荧光发射的系统和方法公开(公告)号：US08101426B2
公开(公告)日：2012-01-24
申请号：US11738860
申请日：2007-04-23
申请人： Gary Durack , Jeremy Hatcher
发明人： Gary Durack , Jeremy Hatcher
CPC分类号： G01N15/1459
摘要： A system and method for the measurement of multiple fluorescence emissions in a flow cytometry system is disclosed where each excitation light source is modulated with a different frequency. A single detector is used to collect the fluorescent emissions excited by all light sources, and the emissions are segregated using Fourier Transform techniques. Systems and methods for the correction of inter-beam coincidence are also disclosed.
摘要翻译： 公开了一种在流式细胞仪系统中测量多种荧光发射的系统和方法，其中每个激发光源以不同的频率进行调制。 使用单个检测器来收集由所有光源激发的荧光发射，并且使用傅里叶变换技术将发射分离。 还公开了用于校正光束间重合的系统和方法。
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8.发明申请SYSTEM AND METHOD FOR THE MEASUREMENT OF MULTIPLE FLUORESCENCE EMISSIONS IN A FLOW CYTOMETRY SYSTEM 有权用于测量流动细胞计数系统中多种荧光发射的系统和方法公开(公告)号：US20120091366A1
公开(公告)日：2012-04-19
申请号：US13329555
申请日：2011-12-19
申请人： Gary Durack , Jeremy Hatcher
发明人： Gary Durack , Jeremy Hatcher
IPC分类号： G01N21/64
CPC分类号： G01N15/1459
摘要： A system and method for the measurement of multiple fluorescence emissions in a flow cytometry system is disclosed where each excitation light source is modulated with a different frequency. A single detector is used to collect the fluorescent emissions excited by all light sources, and the emissions are segregated using Fourier Transform techniques. Systems and methods for the correction of inter-beam coincidence are also disclosed.
摘要翻译： 公开了一种在流式细胞仪系统中测量多种荧光发射的系统和方法，其中每个激发光源以不同的频率进行调制。 使用单个检测器来收集由所有光源激发的荧光发射，并且使用傅里叶变换技术将发射分离。 还公开了用于校正光束间重合的系统和方法。
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公开(公告)号：US08206987B2
公开(公告)日：2012-06-26
申请号：US13106671
申请日：2011-05-12
申请人： Gary Durack , Jeffrey D. Wallace , Gary P. Vandre , Lon A. Westfall , Jeremy T. Hatcher , Niraj V. Nayak
发明人： Gary Durack , Jeffrey D. Wallace , Gary P. Vandre , Lon A. Westfall , Jeremy T. Hatcher , Niraj V. Nayak
CPC分类号： C12N5/0612 , A01N1/0284 , C12N5/06 , C12N5/061 , C12Q1/02 , C12Q3/00 , G01N15/1468 , G01N15/147 , G01N21/63 , G01N21/6428 , G01N33/48 , G01N33/5005 , G01N2015/0065 , G01N2015/1006 , G01N2015/149 , G01N2021/6439 , Y10T436/10 , Y10T436/115831 , Y10T436/12 , Y10T436/25 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： A system and method for sorting a mixture of stained particles in a fluid flow path, including stained particles from two distinguishable groups. The system and method can include an electromagnetic radiation source for exciting fluorescence emissions from the stained particles, a photodetector for detecting the fluorescence emissions from the stained particles, a processor for classifying the stained particles; and a photo-damaging laser for damaging selected particles in the flow path.
摘要翻译： 一种用于在流体流动路径中分选染色颗粒的混合物的系统和方法，包括来自两个可区分的组的染色颗粒。 该系统和方法可以包括用于激发来自染色颗粒的荧光发射的电磁辐射源，用于检测来自染色颗粒的荧光发射的光电检测器，用于对染色颗粒进行分类的处理器; 以及用于损坏流动路径中选定颗粒的光损伤激光器。
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公开(公告)号：US20110256575A1
公开(公告)日：2011-10-20
申请号：US13109640
申请日：2011-05-17
申请人： Gary Durack , Jeffrey D. Wallace , Gary P. Vandre , Lon A. Westfall , Jeremy T. Hatcher , Niraj V. Nayak
发明人： Gary Durack , Jeffrey D. Wallace , Gary P. Vandre , Lon A. Westfall , Jeremy T. Hatcher , Niraj V. Nayak
CPC分类号： C12N5/0612 , A01N1/0284 , C12N5/06 , C12N5/061 , C12Q1/02 , C12Q3/00 , G01N15/1468 , G01N15/147 , G01N21/63 , G01N21/6428 , G01N33/48 , G01N33/5005 , G01N2015/0065 , G01N2015/1006 , G01N2015/149 , G01N2021/6439 , Y10T436/10 , Y10T436/115831 , Y10T436/12 , Y10T436/25 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： A system and method for sorting a mixture of stained particles including a digital signal processor for analyzing and classifying the digital information generated from the particles and providing a sorting signal to a sorting system as a function of the analyzed and classified digital information.
摘要翻译： 一种用于对包括数字信号处理器的染色颗粒的混合物进行分类的系统和方法，用于分析和分类从颗粒产生的数字信息，并根据分析和分类的数字信息向分类系统提供分类信号。
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