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    Glial cell line-derived neurotrophic factor receptor
    1.
    发明申请
    Glial cell line-derived neurotrophic factor receptor 审中-公开

    公开(公告)号：US20060166325A1

    公开(公告)日：2006-07-27

    申请号：US11332638

    申请日：2006-01-12

    申请人： Gary Fox ,  Shuqian Jing ,  Duanzhi Wen

    发明人： Gary Fox ,  Shuqian Jing ,  Duanzhi Wen

    IPC分类号： A61K38/17 ,  C07K14/715 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/715 ,  A61K38/00 ,  C07K14/71

    摘要： The present invention relates to glial cell line-derived neurotrophic factor (GDNF), a potent neurotrophin that exhibits a broad spectrum of biological activities on a variety of cell types from both the central and peripheral nervous systems. The present invention involves the cloning and characterization of a high affinity receptor for GDNF. This molecule has been named GDNF receptor (GDNFR) since it is the first known component of a receptor system. Nucleic acid and amino acid sequences are described for GDNFR protein products. A hydrophobic domain with the features of a signal peptide is found at the amino terminus, while a second hydrophobic domain at the carboxy terminus is involved in the linkage of the receptor to the cell membrane. The lack of a transmembrane domain and cytoplasmic region indicates that GDNFR requires one or more accessory molecules in order to mediate transmembrane signaling. GDNFR mRNA is widely distributed in both nervous system and non-neural tissues, consistent with the similar distribution found for GDNF.

    Polynucleotides encoding a neurotrophic factor receptor
    2.
    发明授权
    Polynucleotides encoding a neurotrophic factor receptor 失效
    编码神经营养因子受体的多核苷酸

    公开(公告)号：US07138251B1

    公开(公告)日：2006-11-21

    申请号：US08866354

    申请日：1997-05-30

    申请人： Gary M. Fox ,  Shuqian Jing ,  Duanzhi Wen

    发明人： Gary M. Fox ,  Shuqian Jing ,  Duanzhi Wen

    IPC分类号： C12N15/12 ,  C12N15/63 ,  C12N15/70 ,  C12N15/85

    CPC分类号： C07K14/71 ,  A61K38/00

    摘要： The present invention relates to glial cell line-derived neurotrophic factor (GDNF), a potent neurotrophin that exhibits a broad spectrum of biological activities on a variety of cell types from both the central and peripheral nervous systems. The present invention involves the cloning and characterization of receptors for GDNF. Nucleic acid and amino acid sequences are described for GDNFR protein products. A hydrophobic domain with the features of a signal peptide is found at the amino terminus, while a second hydrophobic domain at the carboxy terminus is involved in the linkage of the receptor to the cell membrane. The lack of a transmembrane domain and cytoplasmic region indicates that GDNFR requires one or more accessory molecules in order to mediate transmembrane signaling. GDNFR mRNA is widely distributed in both nervous system and non-neural tissues, consistent with the similar distribution found for GDNF.

    摘要翻译： 本发明涉及胶质细胞系衍生的神经营养因子（GDNF），一种强效的神经营养因子，其在来自中枢和外周神经系统的各种细胞类型上表现出广泛的生物活性。 本发明涉及GDNF受体的克隆和表征。 GDNFR蛋白产物描述了核酸和氨基酸序列。 在氨基末端发现具有信号肽特征的疏水结构域，而羧基末端的第二疏水结构域参与受体与细胞膜的连接。 缺少跨膜结构域和细胞质区域表明GDNFR需要一个或多个辅助分子以介导跨膜信号传导。 GDNFR mRNA广泛分布在神经系统和非神经组织中，与GDNF发现的相似分布一致。

    Polynucleotides encoding human glial cell line-derived neurotrophic factor receptor polypeptides
    3.
    发明授权
    Polynucleotides encoding human glial cell line-derived neurotrophic factor receptor polypeptides 失效
    编码人胶质细胞系衍生的神经营养因子受体多肽的多核苷酸

    公开(公告)号：US06455277B1

    公开(公告)日：2002-09-24

    申请号：US08837199

    申请日：1997-04-14

    申请人： Gary M. Fox ,  Shuqian Jing ,  Duanzhi Wen

    发明人： Gary M. Fox ,  Shuqian Jing ,  Duanzhi Wen

    IPC分类号： C12N1512

    CPC分类号： C07K14/715 ,  A61K38/00 ,  C07K14/71

    摘要： The present invention relates to glial cell line-derived neurotophic factor (GDNF), a potent neurotrophin that exhibits a broad spectrum of biological activities on a variety of cell types from both the central and peripheral nervous systems. The present invention involves the cloning and characterization of a high affinity receptor for GDNF. This molecule has been named GDNF receptor (GDNFR) since it is the first known component of a receptor system. Nucleic acid and amino acid sequences are described for GDNFR protein products. A hydrophobic domain with the features of a signal peptide is found at the amino terminus, while a second hydrophobic domain at the carboxy terminus is involved in the linkage of the receptor to the cell membrane. The lack of a transmembrane domain and cytoplasmic region indicates that GDNFR requires one or more accessory molecules in order to mediate transmembrane signaling. GDNFR mRNA is widely distributed in both nervous system and non-neural tissues, consistent with the similar distribution found for GDNF.

    摘要翻译： 本发明涉及胶质细胞系衍生的神经营养因子（GDNF），一种强效的神经营养因子，其在中枢和外周神经系统的各种细胞类型上表现出广泛的生物学活性。 本发明涉及用于GDNF的高亲和力受体的克隆和表征。 该分子已被命名为GDNF受体（GDNFR），因为它是受体系统的第一个已知组分。 GDNFR蛋白产物描述了核酸和氨基酸序列。 在氨基末端发现具有信号肽特征的疏水结构域，而羧基末端的第二疏水结构域参与受体与细胞膜的连接。 缺少跨膜结构域和细胞质区域表明GDNFR需要一个或多个辅助分子以介导跨膜信号传导。 GDNFR mRNA广泛分布在神经系统和非神经组织中，与GDNF发现的相似分布一致。