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公开(公告)号：US5468606A
公开(公告)日：1995-11-21
申请号：US923304
申请日：1992-07-31
IPC分类号： G01N21/21 , G01N21/45 , G01N21/47 , G01N21/77 , G01N33/543 , G01N33/551 , G01N33/552 , G01N33/545
CPC分类号： B82Y30/00 , B82Y15/00 , G01N21/211 , G01N21/4738 , G01N21/77 , G01N33/54366 , G01N33/54373 , G01N33/551 , G01N33/552 , G01N21/45 , Y10S435/808 , Y10S436/805
摘要： Device for detecting the presence or amount of an analyte of interest, having a substrate possessing an optically active surface which exhibits a first color in response to light impinging thereon, and exhibits a second color comprising a combination of wavelengths of light different from the first color or comprising an intensity of at least one wavelength of light different from the first color, in response to the light when the analyte is present on the surface in any amount selected from 0.1 nM, 0.1 ng/ml, 50 fg, and 2.times.10.sup.3 organisms comprising the analyte.
摘要翻译： 用于检测感兴趣的分析物的存在或量的装置，具有具有光学活性表面的基底，所述基底表现出响应于其上的光的第一颜色，并且显示第二颜色，其包括与第一颜色不同的光的波长的组合 或者当所述分析物以选自0.1nM，0.1ng / ml，50fg和2x103生物体的任何量存在于所述表面上时，响应于所述光而包含至少一种不同于所述第一颜色的波长的光的强度，所述生物体包含 分析物。
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公开(公告)号：US5869272A
公开(公告)日：1999-02-09
申请号：US455652
申请日：1995-05-31
IPC分类号： G01N21/21 , G01N21/77 , G01N33/543 , G01N33/551 , G01N33/552 , G01N33/569
CPC分类号： G01N21/78 , G01N21/21 , G01N21/211 , G01N21/6428 , G01N21/77 , G01N33/54366 , G01N33/54373 , G01N33/54386 , G01N33/551 , G01N33/552 , G01N33/56927 , B82Y30/00 , B82Y35/00 , G01N2021/7779 , Y10S435/808 , Y10S435/81 , Y10S436/804 , Y10S436/805 , Y10S436/811 , Y10T436/25 , Y10T436/25375
摘要： Method for the determination of chlamydial or gram negative bacterial antigen comprising contacting a sample potentially containing extracted antigen with an optically active surface comprising an attachment layer, and a layer of non-specific protein.
摘要翻译： 用于测定衣原体或革兰氏阴性细菌抗原的方法，包括使潜在含有提取的抗原的样品与包含附着层的光学活性表面和非特异性蛋白质层接触。
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公开(公告)号：US5541057A
公开(公告)日：1996-07-30
申请号：US075952
申请日：1993-06-10
IPC分类号： G01N21/21 , G01N21/77 , G01N33/543 , G01N33/551 , G01N33/552 , G01N33/569 , C12Q1/70 , G01N21/00 , G01N33/53
CPC分类号： G01N21/78 , G01N21/21 , G01N21/211 , G01N21/6428 , G01N21/77 , G01N33/54366 , G01N33/54373 , G01N33/54386 , G01N33/551 , G01N33/552 , G01N33/56927 , B82Y30/00 , B82Y35/00 , G01N2021/7779 , Y10S435/808 , Y10S435/81 , Y10S436/804 , Y10S436/805 , Y10S436/811 , Y10T436/25 , Y10T436/25375
摘要： Method for detecting the presence or amount of an analyte of interest in a sample by providing a substrate having an optically active surface exhibiting a first color in response to light impinging thereon, and exhibiting a second color comprising a combination of wavelengths of light different from the first color or comprising an intensity of at least one wavelength of light different from the first color, in response to the light when the analyte is present on the surface in an amount selected from any one of 0.1 nM, 0.1 ng/ml, 50 fg, 2.times.10.sup.3 organisms comprising the analyte; and contacting the optically active surface with a sample potentially comprising the analyte of interest under conditions in which the analyte can interact with the optically active surface to cause the optically active surface to exhibit the second color when the analyte is present.
摘要翻译： 用于通过提供具有响应于照射在其上的光呈现出第一颜色的光学活性表面的基底来检测样品中感兴趣分析物的存在或量的方法，以及显示第二种颜色，其包括与 响应于当分析物以0.1nM，0.1ng / ml，50fg中的任一种的形式存在于表面上时的光，第一颜色或包含与第一颜色不同的至少一种波长的光强度 ，包含分析物的2×103个生物体; 并且在分析物可与光学活性表面相互作用的条件下使光学活性表面与潜在地包含感兴趣的分析物的样品接触，以使得当分析物存在时使光学活性表面显示第二种颜色。
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4.发明授权
公开(公告)号：US5482830A
公开(公告)日：1996-01-09
申请号：US76320
申请日：1993-06-10
IPC分类号： G01N21/21 , G01N21/45 , G01N21/47 , G01N21/77 , G01N33/52 , G01N33/543 , G01N33/551 , G01N33/552 , G01N33/544 , C12Q1/00
CPC分类号： B82Y30/00 , B82Y15/00 , G01N21/211 , G01N21/4738 , G01N21/77 , G01N33/526 , G01N33/54366 , G01N33/54373 , G01N33/54386 , G01N33/551 , G01N33/552 , G01N21/45 , Y10S435/808 , Y10S436/805
摘要： Device for detecting the presence or amount of an analyte of interest, having a substrate possessing an optically active surface which exhibits a first color in response to light impinging thereon, and exhibits a second color comprising a combination of wavelengths of light different from the first color or comprising an intensity of at least one wavelength of light different from the first color, in response to the light when the analyte is present on the surface of any amount selected from 0.1 nM, 0.1 ng/ml, 50 fg, and 2.times.10.sup.3 organisms comprising the analyte.
摘要翻译： 用于检测感兴趣的分析物的存在或量的装置，具有具有光学活性表面的基底，所述基底表现出响应于其上的光的第一颜色，并且显示第二颜色，其包括与第一颜色不同的光的波长的组合 或者当分析物存在于选自0.1nM，0.1ng / ml，50fg和2x103生物体的任何量的表面上时响应于光的光包含至少一种不同于第一颜色的波长的强度的强度，包括 分析物。
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5.发明授权公开(公告)号：US07153651B1
公开(公告)日：2006-12-26
申请号：US08950963
申请日：1997-10-15
申请人： Joel A. Drewes , Gregory R. Bogart , Jeffrey B. Etter , Jeffrey W. Steaffens , Rachel M. Ostroff , Mark Crosby
发明人： Joel A. Drewes , Gregory R. Bogart , Jeffrey B. Etter , Jeffrey W. Steaffens , Rachel M. Ostroff , Mark Crosby
CPC分类号： G01N33/54373 , G01N21/7703
摘要： An optical assay device for the detection of an analyte of interest in a sample comprising a support containing channels, an optically functional layer positioned on the support such that the optically functional layer and the support allow for laminar flow of the sample through layers of the device, an attachment layer positioned on the optically functional layer, and an analyte specific receptive layer positioned on the attachment layer.
摘要翻译： 一种用于检测样品中感兴趣分析物的光学测定装置，包括含有通道的载体，位于载体上的光学功能层，使得光学功能层和载体允许样品层流流过该装置的层 ，位于光学功能层上的附着层和位于附着层上的分析物特异性接收层。
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公开(公告)号：US06933112B1
公开(公告)日：2005-08-23
申请号：US09675518
申请日：2000-09-29
申请人： Joel A. Drewes , Gregory R. Bogart , Jeffrey B. Etter , Jeffrey W. Steaffens , Rachel M. Ostroff , Mark Crosby
发明人： Joel A. Drewes , Gregory R. Bogart , Jeffrey B. Etter , Jeffrey W. Steaffens , Rachel M. Ostroff , Mark Crosby
IPC分类号： G01N31/22 , C12M1/00 , C12Q1/68 , G01N21/27 , G01N21/77 , G01N33/543 , G01N33/553 , G01N15/06
CPC分类号： G01N33/54373 , G01N21/7703
摘要： An optical assay device for the detection of an analyte of interest in a sample comprising a support containing channels, an optically functional layer positioned on the support such that the optically functional layer and the support allow for laminar flow of the sample through layers of the device, an attachment layer positioned on the optically functional layer, and an analyte specific receptive layer positioned on the attachment layer.
摘要翻译： 一种用于检测样品中感兴趣分析物的光学测定装置，包括含有通道的载体，位于载体上的光学功能层，使得光学功能层和载体允许样品层流流过该装置的层 ，位于光学功能层上的附着层和位于附着层上的分析物特异性接收层。
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公开(公告)号：US5639671A
公开(公告)日：1997-06-17
申请号：US412600
申请日：1995-03-28
IPC分类号： G01N21/77 , G01N33/543 , G01N33/551 , G01N33/552 , G01N33/545 , G01N33/547
CPC分类号： G01N33/552 , B82Y15/00 , B82Y30/00 , G01N21/78 , G01N33/54366 , G01N33/54373 , G01N33/551 , G01N2021/7779 , G01N2021/7793 , Y10S435/808
摘要： Method for optimizing an optical assay device for an analyte, including the steps of: providing a substrate having a chosen thickness of an optically active layer thereon; providing an attachment layer of a chosen thickness on the optical coating; providing a receptive layer of a chosen thickness for the analyte, wherein at least one of the thicknesses of the optically active layer, attachment layer and receptive layer is varied to provide a plurality of thicknesses of that layer; contacting analyte with the receptive layer under conditions in which an increase in mass on the receptive layer results; and determining the optical thickness of the layer.
摘要翻译： 用于优化用于分析物的光学测定装置的方法，包括以下步骤：提供其上具有选定厚度的光学活性层的基底; 在所述光学涂层上提供所选厚度的附着层; 为分析物提供所选厚度的接受层，其中改变光学活性层，附着层和接收层的厚度中的至少一个以提供该层的多个厚度; 在受体层上的质量增加结果的条件下将分析物与接受层接触; 并确定该层的光学厚度。
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公开(公告)号：US20090232835A1
公开(公告)日：2009-09-17
申请号：US12291344
申请日：2008-11-06
CPC分类号： A61K9/0024 , A61K31/505 , A61K31/513 , A61K35/545 , A61K38/18 , A61K38/193 , A61K38/2046 , A61K47/10 , A61K47/36 , A61K47/38 , A61K2300/00
摘要： A hematopoietic growth factor delivery composition includes a hematopoietic growth factor, a liquid vehicle, a first biocompatible polymer and a second biocompatible polymer. The composition exhibits reverse-thermal viscosity behavior, due to interaction between the first biocompatible polymer and the liquid vehicle. The second biocompatible polymer helps to protect the first biocompatible polymer from being dissolved in vivo following administration to a host.
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9.发明授权公开(公告)号：US09393255B2
公开(公告)日：2016-07-19
申请号：US13363008
申请日：2012-01-31
申请人： Anthony Tutino , Mei Lai , Jeffrey B. Etter
发明人： Anthony Tutino , Mei Lai , Jeffrey B. Etter
IPC分类号： A61K31/706 , A61P35/00 , A61P35/02 , A61K9/00
CPC分类号： A61K31/706 , A61K9/0019
摘要： The present disclosure provides pharmaceutical compositions comprising cytidine analogs for parenteral administration. Also provided are methods of preparing the compositions and methods of treating diseases and disorders using the compositions provided herein.
摘要翻译： 本公开提供了包含用于肠胃外给药的胞苷类似物的药物组合物。 还提供了使用本文提供的组合物制备治疗疾病和病症的组合物和方法的方法。
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10.发明授权Compositions of allosteric hemoglobin modifiers and methods of making the same 有权变构血红蛋白修饰剂的组成及其制备方法公开(公告)号：US07847120B2
公开(公告)日：2010-12-07
申请号：US11112389
申请日：2005-04-22
申请人： Al Quick , Antonio M. Santos , Alexandre J G G Carvalho , Douglas G. Johnson , Jeffrey B. Etter , Christopher Murray
发明人： Al Quick , Antonio M. Santos , Alexandre J G G Carvalho , Douglas G. Johnson , Jeffrey B. Etter , Christopher Murray
IPC分类号： C07C229/00 , C07C65/03
CPC分类号： A61K31/195
摘要： The present invention provides novel compositions of allosteric hemoglobin modifiers which are substantially free of impurities, specifically polymeric impurities. In one embodiment, the novel compositions contain an allosteric hemoglobin modifier compound and less than 100 ppm of the polymeric impurities generated during the preparation of this compound. Included in the present invention are novel methods for preparing allosteric hemoglobin modifiers that are substantially free of polymeric impurities. Also included in the present invention are improved methods for the purification of the product formed by the method of this invention. The novel methods of purification comprise extracting the crude composition with a water immiscible or partially immiscible solvent such as methylisobutyl ketone (MIBK) to lower amounts of impurities, specifically polymeric impurities. Also included are methods to reduce impurities by recrystallization of the crude synthesized product, followed by filtration of the recrystallized product. The present invention also includes the products made by the processes of the invention and methods for analyzing compositions comprised of these products.
摘要翻译： 本发明提供基本上不含杂质，特别是聚合物杂质的变构血红蛋白改性剂的新型组合物。 在一个实施方案中，新型组合物含有变构血红蛋白改性剂化合物，并且在制备该化合物期间产生小于100ppm的聚合物杂质。 本发明包括制备基本上不含聚合物杂质的变构型血红蛋白改性剂的新方法。 本发明还包括用于纯化通过本发明方法形成的产品的改进方法。 新颖的纯化方法包括用与水不混溶或部分不混溶的溶剂如甲基异丁基酮（MIBK）提取粗组合物以降低杂质量，特别是聚合物杂质。 还包括通过粗合成产物的重结晶减少杂质的方法，然后过滤重结晶产物。 本发明还包括通过本发明的方法制备的产品和用于分析由这些产品组成的组合物的方法。
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