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公开(公告)号：US20100015607A1
公开(公告)日：2010-01-21
申请号：US12158953
申请日：2006-12-22
CPC分类号： C12Q1/682 , B82Y5/00 , C12Q1/6816 , C12Q1/6876 , C12Q2565/102 , C12Q2563/155 , C12Q2537/125 , C12Q2525/161
摘要： The present invention relates to compositions and methods for detection and quantification of individual target molecules in biomolecular samples. In particular, the invention relates to coded, labeled probes that are capable of binding to and identifying target molecules based on the probes' label codes. Methods of making and using such probes are also provided. The probes can be used in diagnostic, prognostic, quality control and screening applications.
摘要翻译： 本发明涉及用于检测和定量生物分子样品中各个靶分子的组合物和方法。 特别地，本发明涉及基于探针的标签代码能够结合并鉴定靶分子的经编码的标记的探针。 还提供制造和使用这种探针的方法。 探针可用于诊断，预后，质量控制和筛选应用。
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公开(公告)号：US20130017971A1
公开(公告)日：2013-01-17
申请号：US13530848
申请日：2012-06-22
申请人： Gary K. Geiss , Sean M. Ferree , Philippa J. Webster , James J. Storhoff , Brett Wallden , Emily Payandeh
发明人： Gary K. Geiss , Sean M. Ferree , Philippa J. Webster , James J. Storhoff , Brett Wallden , Emily Payandeh
CPC分类号： C12Q1/6886 , C12Q1/6816 , C12Q1/6837 , C12Q2600/166 , C12Q2537/143 , C12Q2545/101 , C12Q2563/155 , C12Q2545/113 , C12Q2565/1025
摘要： The application describes compositions and methods for detecting the relative expressions of a plurality of target nucleic acid molecules in one assay. The compositions comprise a plurality of probe molecules which specifically bind to one target nucleic acid molecule of a plurality of target nucleic acids in a sample, and a plurality of reference molecules that represent each of the plurality of target nucleic acid molecules, where the probe molecules specifically bind to the plurality of reference molecules, and each of the plurality of reference molecules is present in known amounts in the composition.
摘要翻译： 本申请描述了用于在一个测定中检测多个靶核酸分子的相对表达的组合物和方法。 所述组合物包含多个特异性结合样品中多个靶核酸的靶核酸分子的探针分子和表示多个靶核酸分子中的每一个的多个参考分子，其中所述探针分子 特异性结合多个参考分子，并且多个参考分子中的每一个以已知的量存在于组合物中。
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公开(公告)号：US20110229888A1
公开(公告)日：2011-09-22
申请号：US13049682
申请日：2011-03-16
CPC分类号： C12Q1/6816 , C12Q1/6809 , C12Q1/6827 , C12Q1/6834 , C12Q1/6841 , C12Q2523/303 , C12Q2537/16 , C12Q2565/102 , C12Q2537/125 , C12Q2537/143 , C12Q2539/107 , C12Q2563/155 , C12Q2563/179
摘要： The invention provides compositions and methods for the detection of gene copy number and/or chromosome copy number in a multiplexed reaction. The assays and kits described herein are applicable for the identification, diagnosing, and monitoring of disorders including, but not limited to cancer, developmental and degenerative disease, neurological disorders, and stem cell disorders.
摘要翻译： 本发明提供了在多重反应中检测基因拷贝数和/或染色体拷贝数的组合物和方法。 本文描述的测定和试剂盒适用于疾病的鉴定，诊断和监测，包括但不限于癌症，发育和退行性疾病，神经障碍和干细胞病症。
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4.发明申请METHODS AND COMPUTER SYSTEMS FOR IDENTIFYING TARGET-SPECIFIC SEQUENCES FOR USE IN NANOREPORTERS 有权识别目标特异性序列用于纳米载体的方法和计算机系统公开(公告)号：US20100112710A1
公开(公告)日：2010-05-06
申请号：US12100990
申请日：2008-04-10
申请人： Gary K. Geiss , Tim Dahl , Craig E. Dahl , Eric H. Davidson
发明人： Gary K. Geiss , Tim Dahl , Craig E. Dahl , Eric H. Davidson
IPC分类号： G01N33/53
CPC分类号： C12Q1/6874 , G06F19/22 , Y10T436/143333
摘要： The present invention relates to compositions and methods for detection and quantification of individual target molecules in biomolecular samples. In particular, the invention relates to coded, labeled probes that are capable of binding to and identifying target molecules based on the probes' label codes. Methods, computers, and computer program products for identifying target-specific sequences for inclusion in the probes are also provided, as are methods of making and using such probes. The probes can be used in diagnostic, prognostic, quality control and screening applications.
摘要翻译： 本发明涉及用于检测和定量生物分子样品中各个靶分子的组合物和方法。 特别地，本发明涉及基于探针的标签代码能够结合并鉴定靶分子的经编码的标记的探针。 还提供了用于鉴定用于包含在探针中的靶特异性序列的方法，计算机和计算机程序产品，以及制备和使用这些探针的方法。 探针可用于诊断，预后，质量控制和筛选应用。
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5.发明授权Methods and computer systems for identifying target-specific sequences for use in nanoreporters 有权用于识别用于纳米载体的目标特异性序列的方法和计算机系统公开(公告)号：US08415102B2
公开(公告)日：2013-04-09
申请号：US12100990
申请日：2008-04-10
申请人： Gary K. Geiss , Eric Davidson , Craig E. Dahl
发明人： Gary K. Geiss , Tim Dahl , Eric Davidson
CPC分类号： C12Q1/6874 , G06F19/22 , Y10T436/143333
摘要： The present invention relates to compositions and methods for detection and quantification of individual target molecules in biomolecular samples. In particular, the invention relates to coded, labeled probes that are capable of binding to and identifying target molecules based on the probes' label codes. Methods, computers, and computer program products for identifying target-specific sequences for inclusion in the probes are also provided, as are methods of making and using such probes. The probes can be used in diagnostic, prognostic, quality control and screening applications.
摘要翻译： 本发明涉及用于检测和定量生物分子样品中各个靶分子的组合物和方法。 特别地，本发明涉及基于探针的标签代码能够结合并鉴定靶分子的经编码的标记的探针。 还提供了用于鉴定用于包含在探针中的靶特异性序列的方法，计算机和计算机程序产品，以及制备和使用这些探针的方法。 探针可用于诊断，预后，质量控制和筛选应用。
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