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公开(公告)号:US08663981B2
公开(公告)日:2014-03-04
申请号:US13057529
申请日:2009-08-07
申请人: Gary Kobinger , Heinz Feldmann , Kaylie Tran
发明人: Gary Kobinger , Heinz Feldmann , Kaylie Tran
IPC分类号: C12N15/00
CPC分类号: C07H21/04 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N2760/14122 , C12N2760/14134 , C12N2800/22 , C12N2830/00
摘要: A modified CAG promoter which is capable of driving high levels of expression of sequences of interest inserted downstream therefrom is herein described.
摘要翻译: 本文描述了能够驱动下游插入的高感兴趣序列表达的经修饰的CAG启动子。
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公开(公告)号:US20130158246A1
公开(公告)日:2013-06-20
申请号:US13057529
申请日:2009-08-07
申请人: Gary Kobinger , Heinz Feldmann , Kaylie Tran
发明人: Gary Kobinger , Heinz Feldmann , Kaylie Tran
IPC分类号: C07H21/04
CPC分类号: C07H21/04 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N2760/14122 , C12N2760/14134 , C12N2800/22 , C12N2830/00
摘要: A modified CAG promoter which is capable of driving high levels of expression of sequences of interest inserted downstream therefrom is herein described.
摘要翻译: 本文描述了能够驱动下游插入的高感兴趣序列表达的经修饰的CAG启动子。
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公开(公告)号:US08420372B2
公开(公告)日:2013-04-16
申请号:US12676016
申请日:2008-09-04
申请人: Alexander Bello , Michael Gray , Heinz Feldmann , Gary Kobinger
发明人: Alexander Bello , Michael Gray , Heinz Feldmann , Gary Kobinger
CPC分类号: C12N7/00 , A61K48/0091 , C07K14/005 , C12N15/86 , C12N2500/10 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143
摘要: Porcine tissues were screened for the presence of Adeno-Associated Viruses (AAV). Several AAV sequences were isolated from various porcine tissues, and BLAST analysis confirmed high to low homology with known AAV sequences of different origin. Sequence analysis confirmed the isolation of at least three novel porcine AAV isolates which we named AAVpo1, -po2, and -po3. Novel AAVs derived from porcine tissues may significantly contribute to the generation of new preventive or curative clinical modalities acceptable for human use.
摘要翻译: 筛选猪组织存在腺相关病毒(AAV)。 从各种猪组织中分离出几种AAV序列,BLAST分析确认了与不同来源的已知AAV序列的高至低同源性。 序列分析证实分离至少三种我们命名为AAVpo1,-po2和-po3的新型猪AAV分离物。 衍生自猪组织的新型AAV可显着促成人类可接受的新型预防或治疗性临床方式的产生。
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公开(公告)号:US20100272685A1
公开(公告)日:2010-10-28
申请号:US12676016
申请日:2008-09-04
申请人: Alexander Bello , Michael Gray , Heinz Feldmann , Gary Kobinger
发明人: Alexander Bello , Michael Gray , Heinz Feldmann , Gary Kobinger
CPC分类号: C12N7/00 , A61K48/0091 , C07K14/005 , C12N15/86 , C12N2500/10 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143
摘要: Porcine tissues were screened for the presence of Adeno-Associated Viruses (AAV). Several AAV sequences were isolated from various porcine tissues, and BLAST analysis confirmed high to low homology with known AAV sequences of different origin. Sequence analysis confirmed the isolation of at least three novel porcine AAV isolates which we named AAVpo1, -po2, and -po3. Novel AAVs derived from porcine tissues may significantly contribute to the generation of new preventive or curative clinical modalities acceptable for human use.
摘要翻译: 筛选猪组织存在腺相关病毒(AAV)。 从各种猪组织中分离出几种AAV序列,BLAST分析确认了与不同来源的已知AAV序列的高至低同源性。 序列分析证实分离至少三种我们命名为AAVpo1,-po2和-po3的新型猪AAV分离物。 衍生自猪组织的新型AAV可显着促成人类可接受的新型预防或治疗性临床方式的产生。
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公开(公告)号:US20130323285A1
公开(公告)日:2013-12-05
申请号:US13833523
申请日:2013-03-15
申请人: Ami Patel , Darwyn Kobasa , Gary Kobinger , Shawn Babiuk
发明人: Ami Patel , Darwyn Kobasa , Gary Kobinger , Shawn Babiuk
IPC分类号: A61K39/39
CPC分类号: A61K39/39 , A61K2039/55516 , C07K7/06
摘要: Adjuvant compositions comprising specific 5mer polypeptides in combination with antigen delivery systems and/or immunostimulatory molecules, such as immunostimulatory nucleic acid sequences, for enhancing the immune response of a coadministered antigen, are described.
摘要翻译: 描述了包含与用于增强共同给药的抗原的免疫应答的抗原递送系统和/或免疫刺激分子(例如免疫刺激性核酸序列)组合的特异性5mer多肽的佐剂组合物。
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公开(公告)号:US09211325B2
公开(公告)日:2015-12-15
申请号:US13833523
申请日:2013-03-15
申请人: Ami Patel , Darwyn Kobasa , Gary Kobinger , Shawn Babiuk
发明人: Ami Patel , Darwyn Kobasa , Gary Kobinger , Shawn Babiuk
IPC分类号: A61K39/395 , A61K39/39 , C07K7/06 , A61K39/00
CPC分类号: A61K39/39 , A61K2039/55516 , C07K7/06
摘要: Adjuvant compositions comprising specific 5mer polypeptides in combination with antigen delivery systems and/or immunostimulatory molecules, such as immunostimulatory nucleic acid sequences, for enhancing the immune response of a coadministered antigen, are described.
摘要翻译: 描述了包含与用于增强共同给药的抗原的免疫应答的抗原递送系统和/或免疫刺激分子(例如免疫刺激性核酸序列)组合的特异性5mer多肽的佐剂组合物。
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公开(公告)号:US08404243B2
公开(公告)日:2013-03-26
申请号:US13129514
申请日:2009-11-30
申请人: Ami Patel , Darwyn Kobasa , Gary Kobinger , Shawn Babiuk
发明人: Ami Patel , Darwyn Kobasa , Gary Kobinger , Shawn Babiuk
IPC分类号: A61K39/395
CPC分类号: A61K39/39 , A61K2039/55516 , C07K7/06
摘要: Adjuvant compositions comprising specific 5mer polypeptides in combination with antigen delivery systems and/or immunostimulatory molecules, such as immunostimulatory nucleic acid sequences, for enhancing the immune response of a coadministered antigen, are described.
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公开(公告)号:US20110305720A1
公开(公告)日:2011-12-15
申请号:US13129514
申请日:2009-11-30
申请人: Ami Patel , Darwyn Kobasa , Gary Kobinger , Shawn Babiuk
发明人: Ami Patel , Darwyn Kobasa , Gary Kobinger , Shawn Babiuk
CPC分类号: A61K39/39 , A61K2039/55516 , C07K7/06
摘要: Adjuvant compositions comprising specific 5 mer polypeptides in combination with antigen delivery systems and/or immunostimulatory molecules, such as immunostimulatory nucleic acid sequences, for enhancing the immune response of a coadministered antigen, are described.
摘要翻译: 描述了包含特异性5聚体多肽与抗原递送系统和/或免疫刺激分子(例如免疫刺激性核酸序列)组合的辅助组合物,用于增强共同施用的抗原的免疫应答。
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公开(公告)号:US20050255123A1
公开(公告)日:2005-11-17
申请号:US10510947
申请日:2003-04-28
申请人: James Wilson , Gary Kobinger , Maria Fe Medina
发明人: James Wilson , Gary Kobinger , Maria Fe Medina
IPC分类号: A61K20060101 , A61K39/00 , A61K39/12 , A61K48/00 , C07H21/04 , C07K14/01 , C07K14/08 , C07K14/145 , C12N7/00 , C12N15/83 , C12N15/86 , C12N15/864 , C12N15/867 , C12Q1/70
CPC分类号: C07K14/005 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N15/86 , C12N2710/10343 , C12N2740/15023 , C12N2740/16023 , C12N2740/16043 , C12N2740/16045 , C12N2760/14122 , C12N2760/14134 , C12N2760/14171 , C12N2760/20122 , C12N2810/60 , C12Q1/701
摘要: Chimeric ebola envelope proteins and uses therefore are described. The chimeric envelope proteins are useful for packaging viral vectors and targeting these vectors in vivo, to lung cells following intratracheal delivery or for delivery of molecules, ex vivo, to macrophages and dendritic cells. In another aspect, also provided herein are immunogenic compositions which contain ebola envelope proteins and uses thereof.
摘要翻译: 因此描述了嵌合埃博酚包膜蛋白和用途。 嵌合包膜蛋白可用于包装病毒载体并在体内靶向这些载体,在气管内递送之后转移至肺细胞,或者将其分子外分泌给巨噬细胞和树突状细胞。 在另一方面,本文还提供了含有埃博拉包膜蛋白及其用途的免疫原性组合物。
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