Porcine adeno-associated viruses
    3.
    发明授权
    Porcine adeno-associated viruses 有权
    猪腺相关病毒

    公开(公告)号:US08420372B2

    公开(公告)日:2013-04-16

    申请号:US12676016

    申请日:2008-09-04

    IPC分类号: C12N7/02 C12N15/86 A61K48/00

    摘要: Porcine tissues were screened for the presence of Adeno-Associated Viruses (AAV). Several AAV sequences were isolated from various porcine tissues, and BLAST analysis confirmed high to low homology with known AAV sequences of different origin. Sequence analysis confirmed the isolation of at least three novel porcine AAV isolates which we named AAVpo1, -po2, and -po3. Novel AAVs derived from porcine tissues may significantly contribute to the generation of new preventive or curative clinical modalities acceptable for human use.

    摘要翻译: 筛选猪组织存在腺相关病毒(AAV)。 从各种猪组织中分离出几种AAV序列,BLAST分析确认了与不同来源的已知AAV序列的高至低同源性。 序列分析证实分离至少三种我们命名为AAVpo1,-po2和-po3的新型猪AAV分离物。 衍生自猪组织的新型AAV可显着促成人类可接受的新型预防或治疗性临床方式的产生。

    PEPTIDE ADJUVANTS
    5.
    发明申请
    PEPTIDE ADJUVANTS 有权
    肽类ADJUVANTS

    公开(公告)号:US20130323285A1

    公开(公告)日:2013-12-05

    申请号:US13833523

    申请日:2013-03-15

    IPC分类号: A61K39/39

    摘要: Adjuvant compositions comprising specific 5mer polypeptides in combination with antigen delivery systems and/or immunostimulatory molecules, such as immunostimulatory nucleic acid sequences, for enhancing the immune response of a coadministered antigen, are described.

    摘要翻译: 描述了包含与用于增强共同给药的抗原的免疫应答的抗原递送系统和/或免疫刺激分子(例如免疫刺激性核酸序列)组合的特异性5mer多肽的佐剂组合物。