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公开(公告)号：US08663981B2
公开(公告)日：2014-03-04
申请号：US13057529
申请日：2009-08-07
申请人： Gary Kobinger , Heinz Feldmann , Kaylie Tran
发明人： Gary Kobinger , Heinz Feldmann , Kaylie Tran
IPC分类号： C12N15/00
CPC分类号： C07H21/04 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N2760/14122 , C12N2760/14134 , C12N2800/22 , C12N2830/00
摘要： A modified CAG promoter which is capable of driving high levels of expression of sequences of interest inserted downstream therefrom is herein described.
摘要翻译： 本文描述了能够驱动下游插入的高感兴趣序列表达的经修饰的CAG启动子。
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公开(公告)号：US20130158246A1
公开(公告)日：2013-06-20
申请号：US13057529
申请日：2009-08-07
申请人： Gary Kobinger , Heinz Feldmann , Kaylie Tran
发明人： Gary Kobinger , Heinz Feldmann , Kaylie Tran
IPC分类号： C07H21/04
CPC分类号： C07H21/04 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N2760/14122 , C12N2760/14134 , C12N2800/22 , C12N2830/00
摘要： A modified CAG promoter which is capable of driving high levels of expression of sequences of interest inserted downstream therefrom is herein described.
摘要翻译： 本文描述了能够驱动下游插入的高感兴趣序列表达的经修饰的CAG启动子。
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公开(公告)号：US20100272685A1
公开(公告)日：2010-10-28
申请号：US12676016
申请日：2008-09-04
申请人： Alexander Bello , Michael Gray , Heinz Feldmann , Gary Kobinger
发明人： Alexander Bello , Michael Gray , Heinz Feldmann , Gary Kobinger
CPC分类号： C12N7/00 , A61K48/0091 , C07K14/005 , C12N15/86 , C12N2500/10 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143
摘要： Porcine tissues were screened for the presence of Adeno-Associated Viruses (AAV). Several AAV sequences were isolated from various porcine tissues, and BLAST analysis confirmed high to low homology with known AAV sequences of different origin. Sequence analysis confirmed the isolation of at least three novel porcine AAV isolates which we named AAVpo1, -po2, and -po3. Novel AAVs derived from porcine tissues may significantly contribute to the generation of new preventive or curative clinical modalities acceptable for human use.
摘要翻译： 筛选猪组织存在腺相关病毒（AAV）。 从各种猪组织中分离出几种AAV序列，BLAST分析确认了与不同来源的已知AAV序列的高至低同源性。 序列分析证实分离至少三种我们命名为AAVpo1，-po2和-po3的新型猪AAV分离物。 衍生自猪组织的新型AAV可显着促成人类可接受的新型预防或治疗性临床方式的产生。
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公开(公告)号：US08420372B2
公开(公告)日：2013-04-16
申请号：US12676016
申请日：2008-09-04
申请人： Alexander Bello , Michael Gray , Heinz Feldmann , Gary Kobinger
发明人： Alexander Bello , Michael Gray , Heinz Feldmann , Gary Kobinger
CPC分类号： C12N7/00 , A61K48/0091 , C07K14/005 , C12N15/86 , C12N2500/10 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143
摘要： Porcine tissues were screened for the presence of Adeno-Associated Viruses (AAV). Several AAV sequences were isolated from various porcine tissues, and BLAST analysis confirmed high to low homology with known AAV sequences of different origin. Sequence analysis confirmed the isolation of at least three novel porcine AAV isolates which we named AAVpo1, -po2, and -po3. Novel AAVs derived from porcine tissues may significantly contribute to the generation of new preventive or curative clinical modalities acceptable for human use.
摘要翻译： 筛选猪组织存在腺相关病毒（AAV）。 从各种猪组织中分离出几种AAV序列，BLAST分析确认了与不同来源的已知AAV序列的高至低同源性。 序列分析证实分离至少三种我们命名为AAVpo1，-po2和-po3的新型猪AAV分离物。 衍生自猪组织的新型AAV可显着促成人类可接受的新型预防或治疗性临床方式的产生。
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公开(公告)号：US08513391B2
公开(公告)日：2013-08-20
申请号：US12864584
申请日：2009-01-27
申请人： Steven Jones , Xiangguo Qiu , Heinz Feldmann , Ute Stroeher
发明人： Steven Jones , Xiangguo Qiu , Heinz Feldmann , Ute Stroeher
CPC分类号： A61K39/42 , A61K2039/505 , A61K2039/507 , C07K16/10 , C07K16/462 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/62 , C07K2317/76
摘要： Described herein are a number of Ebola and Marburg monoclonal antibodies.
摘要翻译： 本文描述了许多埃博拉和马尔堡单克隆抗体。
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公开(公告)号：US07897744B2
公开(公告)日：2011-03-01
申请号：US10555073
申请日：2004-04-28
申请人： Frank Plummer , Heinz Feldmann , Steven Jones , Yan Li , Nathalie Bastien , Robert Conrad Brunham , Angela Brooks-Wilson , Robert Holt , Christopher Upton , Rachel Roper , Caroline Astell , Steven Jones
发明人： Frank Plummer , Heinz Feldmann , Steven Jones , Yan Li , Nathalie Bastien , Robert Conrad Brunham , Angela Brooks-Wilson , Robert Holt , Christopher Upton , Rachel Roper , Caroline Astell , Steven Jones
CPC分类号： C07K14/005 , A61K2039/53 , C12N7/00 , C12N2770/20021 , C12N2770/20022 , G01N2333/165
摘要： The invention provides, in part, the genomic sequence of a putative coronavirus, the SARS virus, and provides novel nucleic acid and amino acid sequences that may be used, for example, for the diagnosis, prophylaxis, or therapy of a variety of SARS virus related disorders.
摘要翻译： 本发明部分地提供推定的冠状病毒（SARS）病毒的基因组序列，并且提供可用于例如诊断，预防或治疗各种SARS病毒的新型核酸和氨基酸序列 相关疾病。
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公开(公告)号：US20120283414A1
公开(公告)日：2012-11-08
申请号：US12864584
申请日：2009-01-27
申请人： Steven Jones , Xiangguo Qiu , Heinz Feldmann , Ute Stroeher
发明人： Steven Jones , Xiangguo Qiu , Heinz Feldmann , Ute Stroeher
CPC分类号： A61K39/42 , A61K2039/505 , A61K2039/507 , C07K16/10 , C07K16/462 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/62 , C07K2317/76
摘要： Described herein are a number of Ebola and Marburg monoclonal antibodies.
摘要翻译： 本文描述了许多埃博拉和马尔堡单克隆抗体。
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公开(公告)号：US20070258999A1
公开(公告)日：2007-11-08
申请号：US10555073
申请日：2004-04-28
申请人： Frank Plummer , Heinz Feldmann , Steven Jones , Yan Li , Nathalie Bastien , Robert Brunham , Angela Brooks-Wilson , Robert Holt , Christopher Upton , Rachel Roper , Caroline Astell , Steven Jones
发明人： Frank Plummer , Heinz Feldmann , Steven Jones , Yan Li , Nathalie Bastien , Robert Brunham , Angela Brooks-Wilson , Robert Holt , Christopher Upton , Rachel Roper , Caroline Astell , Steven Jones
CPC分类号： C07K14/005 , A61K2039/53 , C12N7/00 , C12N2770/20021 , C12N2770/20022 , G01N2333/165
摘要： The invention provides, in part, the genomic sequence of a putative coronavirus, the SARS virus, and provides novel nucleic acid and amino acid sequences that may be used, for example, for the diagnosis, prophylaxis, or therapy of a variety of SARS virus related disorders.
摘要翻译： 本发明部分地提供推定的冠状病毒（SARS）病毒的基因组序列，并且提供可用于例如诊断，预防或治疗各种SARS病毒的新型核酸和氨基酸序列 相关疾病。
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9.发明授权公开(公告)号：US08012489B2
公开(公告)日：2011-09-06
申请号：US10522134
申请日：2003-07-28
申请人： Steven Jones , Heinz Feldmann , Ute Stroeher
发明人： Steven Jones , Heinz Feldmann , Ute Stroeher
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5256 , C07K14/005 , C12N2760/10034 , C12N2760/14134 , C12N2760/14234 , C12N2760/20221 , C12N2760/20222 , C12N2760/20232 , C12N2760/20243 , Y02A50/386
摘要： Recombinant VSV viral particles and the use thereof as vaccines for immunization are described.
摘要翻译： 描述了重组VSV病毒颗粒及其作为免疫疫苗的用途。
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