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公开(公告)号：US20110206686A1
公开(公告)日：2011-08-25
申请号：US12681413
申请日：2008-10-03
申请人： Gary Peter Bembridge , Jane Elizabeth Clarkson , Jonathan Henry Ellis , Paul Andrew Hamblin , George Kopsidas , Alan Peter Lewis , Ruth Mcadam
发明人： Gary Peter Bembridge , Jane Elizabeth Clarkson , Jonathan Henry Ellis , Paul Andrew Hamblin , George Kopsidas , Alan Peter Lewis , Ruth Mcadam
IPC分类号： A61K39/395 , C07K16/24 , C12N1/00 , C12N5/10 , A61P29/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P11/00 , A61P3/10 , A61P11/06 , A61P37/08 , A61P37/06
CPC分类号： C07K16/244 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA).
摘要翻译： 本发明涉及到人IL-23的抗原结合蛋白，含有它们的药物制剂以及这种抗原结合蛋白在治疗和/或预防炎性疾病如类风湿关节炎（RA）中的用途。
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公开(公告)号：US20090123479A1
公开(公告)日：2009-05-14
申请号：US12245426
申请日：2008-10-03
申请人： Gary Peter Bembridge , Jane Elizabeth Clarkson , Jonathan Henry Ellis , Paul Andrew Hamblin , George Kopsidas , Alan Peter Lewis , Ruth McAdam
发明人： Gary Peter Bembridge , Jane Elizabeth Clarkson , Jonathan Henry Ellis , Paul Andrew Hamblin , George Kopsidas , Alan Peter Lewis , Ruth McAdam
IPC分类号： A61K39/395 , C07K16/00 , A61P29/00 , A61P37/00 , C12N5/00
CPC分类号： C07K16/244 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA).
摘要翻译： 本发明涉及到人IL-23的抗原结合蛋白，含有它们的药物制剂以及这种抗原结合蛋白在治疗和/或预防炎性疾病如类风湿性关节炎（RA）中的用途。
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公开(公告)号：US20120128689A1
公开(公告)日：2012-05-24
申请号：US13262256
申请日：2010-03-30
IPC分类号： A61K39/395 , A61P17/06 , A61P1/00 , A61P1/04 , A61P29/00 , A61P19/04 , A61P25/28 , A61P25/00 , A61P11/00 , A61P17/00 , A61P37/06 , A61P11/06 , A61P37/08 , A61P37/00 , A61P5/16 , A61P27/02 , C12N5/10 , C12N1/21 , C12N1/19 , C07K16/24
CPC分类号： C07K16/244 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA).
摘要翻译： 本发明涉及到人IL-23的抗原结合蛋白，含有它们的药物制剂以及这种抗原结合蛋白在治疗和/或预防炎性疾病如类风湿性关节炎（RA）中的用途。
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公开(公告)号：US08680245B2
公开(公告)日：2014-03-25
申请号：US13321982
申请日：2010-05-26
申请人： Claire Ashman , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia
发明人： Claire Ashman , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia
IPC分类号： C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , C07K16/247 , C07K16/468 , C07K2317/24 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/76 , Y02A50/41
摘要： The present invention relates to antigen binding proteins to human IL-13, including anti-IL-13 antibodies and anti-IL-3/anti-IL-4 mAbdAbs, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as asthma or IPF.
摘要翻译： 本发明涉及抗人IL-13的抗原结合蛋白，包括抗IL-13抗体和抗IL-3 /抗-IL-4mAbdAb，含有它们的药物制剂以及该抗原结合蛋白在 治疗和/或预防炎性疾病如哮喘或IPF。
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5.发明申请NOGO-A Neutralizing Immunoglobulins for the Treatment of Neurological Diseases 审中-公开NOGO-A中和免疫球蛋白治疗神经疾病公开(公告)号：US20140147435A1
公开(公告)日：2014-05-29
申请号：US13888764
申请日：2013-05-07
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C12N5/0618 , C12N2501/70 , C12N2501/998
摘要： The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorders.
摘要翻译： 本发明涉及NOGO的抗体，含有它们的药物制剂以及这些抗体在治疗和/或预防神经疾病/病症中的用途。
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公开(公告)号：US20100047243A1
公开(公告)日：2010-02-25
申请号：US12526966
申请日：2008-02-12
申请人： Michael Neil Burden , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Radba Shah
发明人： Michael Neil Burden , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Radba Shah
IPC分类号： A61K39/395 , C07K16/00 , C12N5/10 , C12P21/04
CPC分类号： C07K16/2863 , C07K2317/24 , C07K2317/73 , C07K2317/76
摘要： The present invention relates to antibodies or antigen binding fragments thereof which specifically binds to IGF-1R, specifically hIGF-1R. Also disclosed are antibody preparations comprising antibodies or antigen binding fragments of the invention. Methods of producing such antibodies or antigen binding fragments and uses thereof are also included within the scope of the present invention.
摘要翻译： 本发明涉及特异性结合IGF-1R，特别是hIGF-1R的抗体或其抗原结合片段。 还公开了包含本发明的抗体或抗原结合片段的抗体制剂。 生产此类抗体或抗原结合片段的方法及其用途也包括在本发明的范围内。
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公开(公告)号：US20120082682A1
公开(公告)日：2012-04-05
申请号：US13321982
申请日：2010-05-26
申请人： Claire Ashman , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia
发明人： Claire Ashman , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia
CPC分类号： C07K16/244 , A61K2039/505 , C07K16/247 , C07K16/468 , C07K2317/24 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/76 , Y02A50/41
摘要： The present invention relates to antigen binding proteins to human IL-13, including anti-IL-13 antibodies and anti-IL-3/anti-IL-4 mAbdAbs, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as asthma or IPF.
摘要翻译： 本发明涉及抗人IL-13的抗原结合蛋白，包括抗IL-13抗体和抗IL-3 /抗-IL-4mAbdAb，含有它们的药物制剂以及该抗原结合蛋白在 治疗和/或预防炎性疾病如哮喘或IPF。
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公开(公告)号：US07780964B2
公开(公告)日：2010-08-24
申请号：US11177648
申请日：2005-07-06
IPC分类号： A61K39/395 , C07K21/08
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C12N5/0618 , C12N2501/70 , C12N2501/998
摘要： The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorders.
摘要翻译： 本发明涉及NOGO的抗体，含有它们的药物制剂以及这些抗体在治疗和/或预防神经疾病/病症中的用途。
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公开(公告)号：US09394374B2
公开(公告)日：2016-07-19
申请号：US13322224
申请日：2010-05-26
CPC分类号： C07K16/468 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/247 , C07K16/2863 , C07K16/2866 , C07K2317/31 , C07K2317/52 , C07K2317/569 , C07K2318/20 , C07K2319/30
摘要： The invention relates to linkers suitable for use in antigen-binding proteins, certain antigen binding proteins and methods of making such proteins and uses thereof.
摘要翻译： 本发明涉及适用于抗原结合蛋白的接头，某些抗原结合蛋白及其制备方法。
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公开(公告)号：US20140105915A1
公开(公告)日：2014-04-17
申请号：US14122391
申请日：2012-05-24
申请人： Paul Algate , Stephanie Jane Clegg , Jennifer L. Craigen , Paul Andrew Hamblin , Alan Peter Lewis , Patrick Mayes , Radha Shah Parmar , Trevor Anthony Kenneth Wattam
发明人： Paul Algate , Stephanie Jane Clegg , Jennifer L. Craigen , Paul Andrew Hamblin , Alan Peter Lewis , Patrick Mayes , Radha Shah Parmar , Trevor Anthony Kenneth Wattam
IPC分类号： C07K16/28
摘要： The present invention concerns antigen binding proteins and fragments thereof which specifically bind B Cell Maturation Antigen (BCMA), particularly human BCMA (hBCMA) and which inhibit the binding of BAFF and APRIL to the BCMA receptor. Further disclosed are pharmaceutical compositions, screening and medical treatment methods.
摘要翻译： 本发明涉及特异性结合B细胞成熟抗原（BCMA），特别是人BCMA（hBCMA）并且抑制BAFF和APRIL与BCMA受体结合的抗原结合蛋白及其片段。 进一步公开的是药物组合物，筛选和治疗方法。
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