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    ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH GRADED ENZYMATIC REAGENT LAYER AND RELATED METHODS
    3.
    发明申请
    ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH GRADED ENZYMATIC REAGENT LAYER AND RELATED METHODS 审中-公开
    电化学分析测试条与分级酶试剂层及相关方法

    公开(公告)号：US20120199498A1

    公开(公告)日：2012-08-09

    申请号：US13021994

    申请日：2011-02-07

    申请人： Manuel Alvarez-Icaza ,  Alan McNeilage ,  Zuifang Liu ,  Damian Baskeyfield

    发明人： Manuel Alvarez-Icaza ,  Alan McNeilage ,  Zuifang Liu ,  Damian Baskeyfield

    IPC分类号： G01N27/26

    CPC分类号： G01N27/3272 ,  G01N27/3274

    摘要： An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (e.g., a whole blood sample) includes an electrically-insulating substrate, at least one working electrode disposed on the electrically-insulating substrate and a graded enzymatic reagent layer disposed on the at least one working electrode. The graded enzymatic reagent layer includes an upper reaction grade that contains an enzyme. The graded enzymatic layer also has a lower spacer grade devoid of the enzyme, the lower spacer grade disposed between the upper reaction grade and the working electrode such that the upper reaction grade is spaced equidistant from the working electrode by the lower spacer grade by a predetermined distance during use of the electrochemical-based analytical test strip. In addition, the upper reaction grade is configured and constituted such that an enzymatic reaction between the enzyme and a bodily fluid sample applied to the electrochemical-based analytical test strip is localized in the upper reaction grade and the lower spacer grade has predetermined mass transport characteristics for a component of the enzymatic reaction that cause mass transport of the component through the lower spacer grade to the working electrode to be slower than mass transport of the analyte through the bodily fluid sample to the upper reaction grade. A method for determining an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) includes applying a bodily fluid sample to such an electrochemical-based analytical test strip.

    摘要翻译： 用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）的基于电化学的分析测试条包括电绝缘基底，设置在电绝缘基底上的至少一个工作电极 以及设置在所述至少一个工作电极上的分级酶试剂层。 分级的酶试剂层包括含有酶的上反应级。 分级酶层还具有较低的不含酶的间隔物级别，下部间隔物级别位于上部反应级别和工作电极之间，使得上部反应级别通过下部间隔物等级与工作电极等距预定的预定 在使用电化学分析测试条时的距离。 此外，上反应级被配置和构成使得酶和施加到基于电化学的分析测试条上的体液样品之间的酶反应定位在上反应级中，下隔离物级具有预定的质量传递特性 对于通过下部间隔物等级将组分质量输送到工作电极的酶反应的组分比通过体液样品的分析物质量输送到上部反应级要慢。 用于测定体液样品（例如，全血样品）中的分析物（例如葡萄糖）的方法包括将体液样品施加到这种基于电化学的分析测试条上。

    Device for promoting bodily fluid expression from a target site
    9.
    发明申请
    Device for promoting bodily fluid expression from a target site 审中-公开
    用于从目标部位促进体液表达的装置

    公开(公告)号：US20070073191A1

    公开(公告)日：2007-03-29

    申请号：US11236377

    申请日：2005-09-26

    申请人： Anne Thomson ,  Manuel Alvarez-Icaza ,  Wilma Gordon

    发明人： Anne Thomson ,  Manuel Alvarez-Icaza ,  Wilma Gordon

    IPC分类号： A61B5/00

    摘要： A device for promoting the expression of bodily fluid from a target site on a user's body includes a base and a pressure application mechanism. The pressure application mechanism is attached to the base and urges bodily fluid toward the target site. The pressure application mechanism configured for urging the bodily fluid by sequentially increasing an area of contact and applied pressure between the pressure application mechanism and the user's body in the vicinity of the target site. Moreover, the area of contact and applied pressure sequentially increases in a direction toward the target site.

    摘要翻译： 用于在使用者身体上从目标部位促进体液表达的装置包括底座和压力施加机构。 压力施加机构附着在基座上，并向身体部位引导体液。 压力施加机构，其构造成通过在目标部位附近依次增加压力施加机构与使用者的身体之间的接触面积和施加的压力来推压体液。 此外，接触面积和施加压力在朝向目标部位的方向上依次增加。

    Analyte monitoring system with a device for promoting bodily fluid expression from a target site
    10.
    发明申请
    Analyte monitoring system with a device for promoting bodily fluid expression from a target site 审中-公开
    分析物监测系统，具有用于从目标部位促进体液表达的装置

    公开(公告)号：US20070073187A1

    公开(公告)日：2007-03-29

    申请号：US11236050

    申请日：2005-09-26

    申请人： Anne Thomson ,  Manuel Alvarez-Icaza ,  Wilma Gordon

    发明人： Anne Thomson ,  Manuel Alvarez-Icaza ,  Wilma Gordon

    IPC分类号： A61B5/00

    摘要： An analyte monitoring system for the determination of an analyte in a bodily fluid sample includes a housing, a meter for the determination of an analyte in a bodily fluid sample, and a device for promoting the expression of the bodily fluid sample from a target site. The device for promoting expression of bodily fluid has a pressure application mechanism for urging bodily fluid toward the target site attached to the housing. In addition, the pressure application mechanism is configured for urging the bodily fluid by sequentially increasing an area of contact and applied pressure between the pressure application mechanism and the user's body in the vicinity of the target site with the area of contact and applied pressure sequentially increasing in a direction toward the target site.

    摘要翻译： 用于测定体液样品中的分析物的分析物监测系统包括壳体，用于测定体液样品中的分析物的仪表，以及用于促进体液样品从靶位点表达的装置。 用于促进体液表达的装置具有用于将体液推向连接到壳体的目标部位的压力施加机构。 此外，压力施加机构构造成通过在接触面积和施加压力依次增加的情况下依次增加目标部位附近的压力施加机构和使用者身体之间的接触面积和施加压力来推压体液 朝向目标地点的方向。