公开(公告)号：US20140057288A1

公开(公告)日：2014-02-27

申请号：US13942421

申请日：2013-07-15

Applicant: GENENTECH, INC.

Inventor： Kang Li ,  Sek Chung Fung ,  Zhengbin Yao

IPC: G01N33/574

CPC classification number: G01N33/57492 ,  C07K16/28 ,  C07K2317/56 ,  G01N33/574 ,  G01N33/57488 ,  G01N2333/705

Abstract: The present invention relates to novel antibodies that bind specifically to human Notch 3 and their use in the detection and/or diagnosis of Notch 3 related diseases, such as cancer. The present invention also includes nucleic acids encoding these novel antibodies, vectors and cell lines harboring the nucleic acids, and kits comprising the antibodies for use in the detection and diagnosis.

Abstract translation: 本发明涉及与人Notch3特异性结合的新型抗体及其在检测和/或诊断Notch3相关疾病如癌症中的用途。 本发明还包括编码这些新型抗体的核酸，携带核酸的载体和细胞系，以及包含用于检测和诊断的抗体的试剂盒。

公开(公告)号：US20140335078A1

公开(公告)日：2014-11-13

申请号：US14270848

申请日：2014-05-06

Applicant: Genentech, Inc.

Inventor： Sek Chung Fung ,  Zhengbin Yao

IPC: C07K16/18 ,  C12N15/113 ,  A61K45/06 ,  A61K38/17 ,  A61K39/395

CPC classification number: C07K16/18 ,  A61K38/00 ,  A61K38/1709 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2300/00 ,  C12N15/113

Abstract: The present invention relates to the treatment of ocular diseases and conditions by administering a complement pathway inhibitor, particularly an alternative pathway inhibitor. Ocular diseases include age-related macular degeneration, diabetic retinopathy, and ocular angiogenesis. One embodiment comprises the administration of an anti-Factor D antibody in the form of a whole antibody, a Fab fragment or a single domain antibody. Other complement component inhibitors that may be useful in the present method include Factor H or inhibitors that block the action of properdin, factor B, factor Ba, factor Bb, C2, C2a, C3a, C5, C5a, C5, C6, C7, C8, C9, or C5b-9.

Abstract translation: 本发明涉及通过施用补体途径抑制剂，特别是替代途径抑制剂来治疗眼部疾病和病症。 眼部疾病包括年龄相关性黄斑变性，糖尿病性视网膜病变和眼血管发生。 一个实施方案包括以全抗体，Fab片段或单结构域抗体的形式施用抗因子D抗体。 可用于本发明方法的其它补体成分抑制剂包括因子H或阻断适当素，因子B，因子Ba，因子Bb，C2，C2a，C3a，C5，C5a，C5，C6，C7，C8的作用的抑制剂 ，C9或C5b-9。

公开(公告)号：US09873734B2

公开(公告)日：2018-01-23

申请号：US13669230

申请日：2012-11-05

Applicant: Genentech, Inc.

Inventor： Sek Chung Fung ,  Kang Li ,  Zhengbin Yao

IPC: A61K39/00 ,  C07K16/18 ,  C07K14/705 ,  C07K16/28

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/28 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/30

Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

公开(公告)号：US08956811B2

公开(公告)日：2015-02-17

申请号：US13942421

申请日：2013-07-15

Applicant: Genentech, Inc.

Inventor： Kang Li ,  Sek Chung Fung ,  Zhengbin Yao

IPC: C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  G01N33/50 ,  G01N33/53 ,  G01N33/574 ,  G01N33/577 ,  A61K39/00 ,  A61K39/395

CPC classification number: G01N33/57492 ,  C07K16/28 ,  C07K2317/56 ,  G01N33/574 ,  G01N33/57488 ,  G01N2333/705

Abstract: The present invention relates to novel antibodies that bind specifically to human Notch 3 and their use in the detection and/or diagnosis of Notch 3 related diseases, such as cancer. The present invention also includes nucleic acids encoding these novel antibodies, vectors and cell lines harboring the nucleic acids, and kits comprising the antibodies for use in the detection and diagnosis.

Abstract translation: 本发明涉及与人Notch3特异性结合的新型抗体及其在检测和/或诊断Notch3相关疾病如癌症中的用途。 本发明还包括编码这些新型抗体的核酸，携带核酸的载体和细胞系，以及包含用于检测和诊断的抗体的试剂盒。