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    Sterile sealed heterogeneous medicament delivery device
    2.
    发明授权
    Sterile sealed heterogeneous medicament delivery device 有权

    公开(公告)号：US11571506B2

    公开(公告)日：2023-02-07

    申请号：US16384410

    申请日：2019-04-15

    Applicant: Genentech, Inc.

    Inventor： Joshua Horvath ,  Lionel Vedrine ,  Nathan A. Goltz ,  Mukund R. Patel ,  Aaron D. Chesterman ,  Mayumi Naito Bowen

    IPC: A61M5/00 ,  A61L2/08 ,  A61M5/178 ,  A61M5/145 ,  A61M5/20 ,  A61M5/315 ,  A61L31/04

    Abstract: Apparatus and methods for delivering medicament to a patient. The apparatus may include elements with different capacities to attenuate or absorb sterilizing radiation. The apparatus may include a medicament delivery assembly with interactive elements for dose-setting, priming and medicament ejection. The assembly may include a chamber housing a radiation-sensitive medicament present in the apparatus during sterilization by electron beam. The assembly may include an actuator chassis, a drive mechanism, a needle-priming mechanism and a fluid-displacement mechanism including a fluid-displacement member. The chassis may be fixed, relative to an outlet, to the chamber. The member may be slidingly and/or threadingly engaged with the chassis, and may be configured to move relative to the outlet to deliver the medicament through the outlet. Assembly elements may be nested coaxially and/or stacked axially. The assembly may include at least one hollow region. The hollow region may reduce beam attenuation or reduce radiation absorption.

    VERSATILE SYRINGE PLATFORM
    3.
    发明申请
    VERSATILE SYRINGE PLATFORM 有权

    公开(公告)号：US20210138158A1

    公开(公告)日：2021-05-13

    申请号：US16931602

    申请日：2020-07-17

    Applicant: Genentech, Inc.

    Inventor： Lionel Vedrine ,  Steven N. Roe ,  Mukund Patel

    IPC: A61M5/315 ,  A61M5/24 ,  A61F9/00 ,  A61M5/31 ,  A61M5/32 ,  A61M5/36

    Abstract: Apparatus and methods for medicament delivery. The apparatus may include, and the methods may involve, a delivery device for delivering a target amount of the medicament from a distal end of the device. The device may include a rod for moving a plunger that discharges the medicament from the distal end. The device may avoid or reduce deformation of the plunger during the discharge. The plunger motion may be stopped by detent that interacts with the rod. The apparatus and the methods may provide an operator indication of progress of stages of operation. The device may feature triggers corresponding to stages of medicament displacement from the device, such as pre-delivery stages, including priming.

    VERSATILE SYRINGE PLATFORM
    4.
    发明申请
    VERSATILE SYRINGE PLATFORM 审中-公开

    公开(公告)号：US20160325047A1

    公开(公告)日：2016-11-10

    申请号：US14962554

    申请日：2015-12-08

    Applicant: Genentech, Inc.

    Inventor： Lionel Vedrine ,  Steven N. Roe ,  Mukund Patel

    IPC: A61M5/315 ,  A61M5/36 ,  A61M5/24 ,  A61F9/00 ,  A61M5/31 ,  A61M5/32

    Abstract: Apparatus and methods for medicament delivery. The apparatus may include, and the methods may involve, a delivery device for delivering a target amount of the medicament from a distal end of the device. The device may include a rod for moving a plunger that discharges the medicament from the distal end. The device may avoid or reduce deformation of the plunger during the discharge. The plunger motion may be stopped by detent that interacts with the rod. The apparatus and the methods may provide an operator indication of progress of stages of operation. The device may feature triggers corresponding to stages of medicament displacement from the device, such as pre-delivery stages, including priming.

    Abstract translation: 用于药物输送的装置和方法 该装置可以包括并且该方法可以包括用于从装置的远端递送目标量的药物的递送装置。 该装置可以包括用于移动从远端排出药物的柱塞的杆。 该装置可以避免或减少放电期间柱塞的变形。 柱塞运动可以通过与杆相互作用的制动器来停止。 装置和方法可以提供操作员对操作阶段的进展的指示。 该装置可以具有对应于来自装置的药物置换阶段的触发器，例如预输送阶段，包括起动。

    APPARATUS AND METHODS FOR SEALING A MEDICAMENT WITHIN A MEDICAL DELIVERY DEVICE
    5.
    发明申请
    APPARATUS AND METHODS FOR SEALING A MEDICAMENT WITHIN A MEDICAL DELIVERY DEVICE 审中-公开

    公开(公告)号：US20200261314A1

    公开(公告)日：2020-08-20

    申请号：US16854144

    申请日：2020-04-21

    Applicant: Genentech, Inc.

    Inventor： Lionel Vedrine

    IPC: A61J1/14 ,  F26B5/06 ,  A61M39/20 ,  B65B63/08 ,  B65B7/16 ,  B65B3/00

    Abstract: Apparatus and methods for lyophilizing and sealing a medicament within a medical delivery device having an opening. The apparatus may include a stopper for sealing the opening. The stopper may have one or more elongated members extending from a base, in a direction that is parallel to a central axis of the base. One or more of the members may be set radially away from the axis and define a coaxial central well. The member or members may define a void. The elongated member or members may engage a device inner wall and support the base away from the opening. The void may provide gas exchange between a device interior and a device exterior. The gas may be a lyophilization byproduct that escapes from the device interior between the inner wall, the base and the member or members. The stopper may be advanced into the device to seal the opening.

    Apparatus and methods for sealing a medicament within a medical delivery device
    7.
    发明授权
    Apparatus and methods for sealing a medicament within a medical delivery device 有权

    公开(公告)号：US10729616B2

    公开(公告)日：2020-08-04

    申请号：US14813788

    申请日：2015-07-30

    Applicant: Genentech, Inc.

    Inventor： Lionel Vedrine

    IPC: B65D39/00 ,  A61J1/14 ,  B65B3/00 ,  B65B7/16 ,  B65B63/08 ,  A61M39/20 ,  F26B5/06

    Abstract: Apparatus and methods for lyophilizing and sealing a medicament within a medical delivery device having an opening. The apparatus may include a stopper for sealing the opening. The stopper may have one or more elongated members extending from a base, in a direction that is parallel to a central axis of the base. One or more of the members may be set radially away from the axis and define a coaxial central well. The member or members may define a void. The elongated member or members may engage a device inner wall and support the base away from the opening. The void may provide gas exchange between a device interior and a device exterior. The gas may be a lyophilization byproduct that escapes from the device interior between the inner wall, the base and the member or members. The stopper may be advanced into the device to seal the opening.

    Versatile syringe platform
    8.
    发明授权
    Versatile syringe platform 有权

    公开(公告)号：US11633545B2

    公开(公告)日：2023-04-25

    申请号：US16931602

    申请日：2020-07-17

    Applicant: Genentech, Inc.

    Inventor： Lionel Vedrine ,  Steven N. Roe ,  Mukund Patel

    IPC: A61M5/315 ,  A61M5/24 ,  A61F9/00 ,  A61M5/31 ,  A61M5/32 ,  A61M5/36 ,  A61M5/28 ,  A61M5/20 ,  B29C45/16 ,  B29L31/00

    Abstract: Apparatus and methods for medicament delivery. The apparatus may include, and the methods may involve, a delivery device for delivering a target amount of the medicament from a distal end of the device. The device may include a rod for moving a plunger that discharges the medicament from the distal end. The device may avoid or reduce deformation of the plunger during the discharge. The plunger motion may be stopped by detent that interacts with the rod. The apparatus and the methods may provide an operator indication of progress of stages of operation. The device may feature triggers corresponding to stages of medicament displacement from the device, such as pre-delivery stages, including priming.

    Versatile syringe platform
    9.
    发明授权
    Versatile syringe platform 有权

    公开(公告)号：US10765811B2

    公开(公告)日：2020-09-08

    申请号：US14962554

    申请日：2015-12-08

    Applicant: Genentech, Inc.

    Inventor： Lionel Vedrine ,  Steven N. Roe ,  Mukund Patel

    IPC: A61M5/315 ,  A61M5/24 ,  A61F9/00 ,  A61M5/31 ,  A61M5/32 ,  A61M5/36 ,  A61M5/28 ,  A61M5/20 ,  B29C45/16 ,  B29L31/00

    Abstract: Apparatus and methods for medicament delivery. The apparatus may include, and the methods may involve, a delivery device for delivering a target amount of the medicament from a distal end of the device. The device may include a rod for moving a plunger that discharges the medicament from the distal end. The device may avoid or reduce deformation of the plunger during the discharge. The plunger motion may be stopped by detent that interacts with the rod. The apparatus and the methods may provide an operator indication of progress of stages of operation. The device may feature triggers corresponding to stages of medicament displacement from the device, such as pre-delivery stages, including priming.

    APPARATUS AND METHODS FOR LOW-VOLUME MEDICAMENT DELIVERY
    10.
    发明申请
    APPARATUS AND METHODS FOR LOW-VOLUME MEDICAMENT DELIVERY 审中-公开

    公开(公告)号：US20190328980A1

    公开(公告)日：2019-10-31

    申请号：US16412654

    申请日：2019-05-15

    Applicant: Genentech, Inc.

    Inventor： Lionel Vedrine ,  Ariel Waitz

    IPC: A61M5/34 ,  A61M5/315 ,  B65D83/28 ,  A61M5/32 ,  A61M5/31

    Abstract: Apparatus and methods for delivering medicament. The apparatus may include a fitting for a fluid dispenser. The fitting may include a detent that is configured to limit insertion of the dispenser into the fitting by contacting a terminal surface of the dispenser; and a seal for sealing against the surface. The apparatus may include an insert for the fitting. The insert may include a gasket to seal against the terminal surface of the dispenser; a proximal rim to engage a lateral wall of the dispenser; and a connector fixed to the gasket and the rim. The apparatus may include a coupler to engage a pre-filled dispenser; and a body defining a passageway that is configured to be placed in fluid communication with the dispenser. The apparatus may include a dispenser that includes a detent and a seal. The detent may limit insertion of the dispenser into a fitting.

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