-
1.
公开(公告)号:US20190187126A1
公开(公告)日:2019-06-20
申请号:US15848302
申请日:2017-12-20
发明人: Matthew Jeremiah MISNER , Gregory Andrew GROSSMANN , Cathryn Ellen OLSEN , John Richard NELSON , David Roger MOORE , Paul Michael SMIGELSKI, JR. , John Thomas CONNELLY , Benjamin David GRANT , Bernhard Hans WEIGL
IPC分类号: G01N33/493 , C07K1/22 , B01D15/08 , G01N33/50 , G01N33/569 , B01D63/02 , C12M1/26 , A61B10/00
CPC分类号: G01N33/493 , A61B10/007 , A61M2202/0028 , A61M2202/005 , A61M2202/0071 , A61M2202/0496 , B01D15/08 , B01D63/02 , C07K1/22 , C12M33/14 , G01N33/5038 , G01N33/558 , G01N33/569 , G01N33/5695 , G01N2015/1493
摘要: A device for rapid detection of a tuberculosis lipoarabinomannan (TB-LAM) is provided. The device includes a pre-concentrator unit for concentrating the TB-LAM comprising: an ion-exchange medium comprising one or more ligands configured to capture the TB-LAM from the source biological sample, wherein the captured-TB-LAM is eluted from the ion-exchange medium as an eluate comprising a concentrated form of TB-LAM; a cassette; a lateral flow assay unit disposed in the cassette; and an integration unit attached to the pre-concentrator unit and the cassette. The integration unit is configured to operatively couple and de-couple the pre-concentrator unit and the cassette. The pre-concentrator unit and the lateral flow assay unit disposed in the cassette are in a fluidic communication in a coupled form. The device for rapid detection of TB-LAM further comprises a dilutor unit.