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    SMALL APERTURE LARGE ELECTRODE CELL
    3.
    发明申请
    SMALL APERTURE LARGE ELECTRODE CELL 审中-公开
    小孔大电极细胞

    公开(公告)号：US20170059546A1

    公开(公告)日：2017-03-02

    申请号：US14841127

    申请日：2015-08-31

    Applicant: Genia Technologies, Inc.

    Inventor： John Foster ,  Morgan Mager

    IPC: G01N33/487 ,  G01N27/447 ,  H01L29/40

    Abstract: A nanopore cell includes a conductive layer and a working electrode disposed above the conductive layer and at the bottom of a well into which an electrolyte may be contained, such that at least a portion of a top base surface area of the working electrode is exposed to the electrolyte. The nanopore cell further includes a first insulating wall disposed above the working electrode and surrounding a lower section of a well, and a second insulating wall disposed above the first insulating wall and surrounding an upper section of the well, forming an overhang above the lower section of the well. The upper section of the well includes an opening that a membrane may span across, and wherein a base surface area of the opening is smaller than the at least a portion of the top base surface area of the working electrode that is exposed to the electrolyte.

    Abstract translation: 纳米孔单元包括导电层和工作电极，其设置在导电层上方和可以容纳电解质的阱的底部，使得工作电极的顶部基面表面区域的至少一部分暴露于 电解液。 纳米孔单元还包括设置在工作电极上方并围绕阱的下部的第一绝缘壁和设置在第一绝缘壁上方并围绕阱的上部的第二绝缘壁，在第二绝缘壁的下部 的井。 阱的上部包括膜可跨越的开口，并且其中开口的基面面积小于暴露于电解质的工作电极的顶部基面表面区域的至少一部分。

    USE OF TITANIUM NITRIDE AS AN ELECTRODE IN NON-FARADAIC ELECTROCHEMICAL CELL
    4.
    发明申请
    USE OF TITANIUM NITRIDE AS AN ELECTRODE IN NON-FARADAIC ELECTROCHEMICAL CELL 审中-公开
    硝酸钛作为电极在非电化学电池中的应用

    公开(公告)号：US20170037467A1

    公开(公告)日：2017-02-09

    申请号：US14818977

    申请日：2015-08-05

    Applicant: Genia Technologies, Inc.

    Inventor： John Foster ,  Jason Komadina

    IPC: C12Q1/68 ,  G01N27/447 ,  C23C14/06 ,  C23C14/00 ,  C23C14/34

    CPC classification number: C12Q1/6874 ,  C12Q1/6869 ,  C23C14/0089 ,  C23C14/0641 ,  C23C14/345 ,  G01N27/44791 ,  G01N33/48721 ,  C12Q2527/125 ,  C12Q2565/631

    Abstract: A nanopore cell includes a conductive layer. The nanopore cell further includes a titanium nitride (TiN) working electrode disposed above the conductive layer. The nanopore cell further includes insulating walls disposed above the TiN working electrode, wherein the insulating walls and the TiN working electrode form a well into which an electrolyte may be contained. In some embodiments, the TiN working electrode comprises a spongy and porous TiN working electrode that is deposited by a deposition technique with conditions tuned to deposit sparsely-spaced TiN columnar structures or columns of TiN crystals above the conductive layer.

    Abstract translation: 纳米孔单元包括导电层。 纳米孔单元还包括设置在导电层上方的氮化钛（TiN）工作电极。 纳米孔单元还包括设置在TiN工作电极上方的绝缘壁，其中绝缘壁和TiN工作电极形成可包含电解质的阱。 在一些实施例中，TiN工作电极包括通过沉积技术沉积的海绵状和多孔的TiN工作电极，该沉积技术具有被调整以在导电层上方沉积稀疏间隔的TiN柱状结构或TiN晶体柱的条件。

    Process for biosensor well formation
    5.
    发明授权
    Process for biosensor well formation 有权

    公开(公告)号：US10273536B2

    公开(公告)日：2019-04-30

    申请号：US15066117

    申请日：2016-03-10

    Applicant: Genia Technologies, Inc.

    Inventor： Randall W. Davis ,  Edward Shian Liu ,  Eric Takeshi Harada ,  Anne Aguirre ,  Andrew Trans ,  James Pollard ,  Cynthia Cech ,  Hui Tian ,  Robert Yuan ,  John Foster ,  Roger Chen

    IPC: G01N27/327 ,  C12Q1/6869 ,  C12M1/34 ,  G01N33/487 ,  G01N27/447

    Abstract: A biochip for molecular detection and sensing is disclosed. The biochip includes a substrate. The biochip includes a plurality of discrete sites formed on the substrate having a density of greater than five hundred wells per square millimeter. Each discrete site includes sidewalls disposed on the substrate to form a well. Each discrete site includes an electrode disposed at the bottom of the well. In some embodiments, the wells are formed such that cross-talk between the wells is reduced. In some embodiments, the electrodes disposed at the bottom of the wells are organized into groups of electrodes, wherein each group of electrodes shares a common counter electrode. In some embodiments, the electrode disposed at the bottom of the well has a dedicated counter electrode. In some embodiments, surfaces of the sidewalls are silanized such that the surfaces facilitate the forming of a membrane in or adjacent to the well.

    ELECTROCHEMICAL CELL WITH INCREASED CURRENT DENSITY
    7.
    发明申请
    ELECTROCHEMICAL CELL WITH INCREASED CURRENT DENSITY 审中-公开
    电化学电池具有增加的电流密度

    公开(公告)号：US20170058397A1

    公开(公告)日：2017-03-02

    申请号：US14841120

    申请日：2015-08-31

    Applicant: Genia Technologies, Inc.

    Inventor： Morgan Mager ,  John Foster

    IPC: C23C14/35 ,  C23C14/06 ,  C23C14/34 ,  C12Q1/68

    CPC classification number: C23C14/35 ,  C12Q1/6874 ,  C23C14/0641 ,  C23C14/3414 ,  G01N33/48721

    Abstract: A nanopore cell is disclosed. The nanopore cell includes an electrolyte well having a bottom base, a surrounding sidewall, and a hydrophobic surface above the surrounding sidewall. The nanopore cell further includes a first layer of electrode material disposed on the bottom base of the electrolyte well. The nanopore cell further includes a second layer of electrode material disposed on the surrounding sidewall of the electrolyte well and electrically connected to the first layer of electrode material. The first layer of electrode material and the second layer of electrode material are configured to jointly provide capacitive coupling when an electrolyte is placed in the electrolyte well.

    Abstract translation: 公开了一种纳米孔细胞。 纳米孔单元包括电解质阱，其具有底部基底，周围侧壁和在周围侧壁上方的疏水表面。 纳米孔电池还包括设置在电解质阱的底部基底上的第一电极材料层。 纳米孔单元还包括设置在电解质阱的周围侧壁上并电连接到第一电极材料层的第二电极材料层。 第一层电极材料和第二层电极材料构造成当电解质放置在电解质井中时共同提供电容耦合。

    Process for biosensor well formation
    8.
    发明授权
    Process for biosensor well formation 有权
    生物传感器井形成过程

    公开(公告)号：US09322062B2

    公开(公告)日：2016-04-26

    申请号：US14521427

    申请日：2014-10-22

    Applicant: Genia Technologies, Inc.

    Inventor： Randall W. Davis ,  Edward Shian Liu ,  Eric Takeshi Harada ,  Anne Aguirre ,  Andrew Trans ,  James Pollard ,  Cynthia Cech ,  Hui Tian ,  Robert Yuan ,  John Foster ,  Roger Chen

    IPC: G01N27/327 ,  C12Q1/68 ,  C12M1/34

    CPC classification number: C12Q1/6869 ,  C12M1/34 ,  G01N27/3277 ,  G01N27/3278 ,  G01N27/44791 ,  G01N33/48721 ,  C12Q2565/607 ,  C12Q2565/631

    Abstract: A biochip for molecular detection and sensing is disclosed. The biochip includes a substrate. The biochip includes a plurality of discrete sites formed on the substrate having a density of greater than five hundred wells per square millimeter. Each discrete site includes sidewalls disposed on the substrate to form a well. Each discrete site includes an electrode disposed at the bottom of the well. In some embodiments, the wells are formed such that cross-talk between the wells is reduced. In some embodiments, the electrodes disposed at the bottom of the wells are organized into groups of electrodes, wherein each group of electrodes shares a common counter electrode. In some embodiments, the electrode disposed at the bottom of the well has a dedicated counter electrode. In some embodiments, surfaces of the sidewalls are silanized such that the surfaces facilitate the forming of a membrane in or adjacent to the well.

    Abstract translation: 公开了用于分子检测和感测的生物芯片。 生物芯片包括基底。 生物芯片包括形成在衬底上的多个离散位置，其密度大于每平方毫米500个孔。 每个离散部位包括设置在基底上以形成孔的侧壁。 每个离散位置包括设置在井的底部的电极。 在一些实施例中，形成井，使得井之间的串扰减少。 在一些实施例中，设置在阱的底部的电极被组织成电极组，其中每组电极共享公共对电极。 在一些实施例中，设置在阱底部的电极具有专用的对电极。 在一些实施例中，侧壁的表面被硅烷化，使得表面有助于在孔中或邻近孔的膜的形成。

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